SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 3wew HTDX DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 6 GLN A 113
PHE A  37
HIS A  62
ASN A  65
 None
None
None
MG  A 301 (-3.9A)
 1.44A 1tt0A-3wewA:
undetectable		 1tt0A-3wewA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 3wew HTDX DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 6 GLN A 113
PHE A  37
HIS A  62
ASN A  65
 None
None
None
MG  A 301 (-3.9A)
 1.42A 1tt0B-3wewA:
undetectable		 1tt0B-3wewA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 3wew HTDX DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 6 GLN A 113
PHE A  37
HIS A  62
ASN A  65
 None
None
None
MG  A 301 (-3.9A)
 1.43A 1tt0C-3wewA:
undetectable		 1tt0C-3wewA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 3wew HTDX DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 6 GLN A 113
PHE A  37
HIS A  62
ASN A  65
 None
None
None
MG  A 301 (-3.9A)
 1.44A 1tt0D-3wewA:
1.9		 1tt0D-3wewA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 3wew HTDX DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 6 THR A  34
PHE A 210
HIS A  62
ASN A  65
 None
None
None
MG  A 301 (-3.9A)
 1.37A 1tt0D-3wewA:
1.9		 1tt0D-3wewA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 3wew HTDX DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 6 GLN A 113
PHE A  37
HIS A  62
ASN A  65
 None
None
None
MG  A 301 (-3.9A)
 1.42A 3lskB-3wewA:
undetectable		 3lskB-3wewA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 3wew HTDX DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 6 GLN A 113
PHE A  37
HIS A  62
ASN A  65
 None
None
None
MG  A 301 (-3.9A)
 1.39A 3lskD-3wewA:
undetectable		 3lskD-3wewA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3wew HTDX DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  37
PHE A  55
VAL A  97
ALA A  60
HIS A  62
 None
 1.38A 3u9fG-3wewA:
undetectable
3u9fH-3wewA:
undetectable		 3u9fG-3wewA:
19.77
3u9fH-3wewA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 3wew HTDX DEHYDRATASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 147
TYR A 223
ASN A 195
 None
 0.97A 4ffwB-3wewA:
undetectable		 4ffwB-3wewA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 3wew HTDX DEHYDRATASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 156
ILE A 153
TYR A  19
ALA A 191
LEU A 146
 None
 1.24A 5zwrB-3wewA:
undetectable		 5zwrB-3wewA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3wew HTDX DEHYDRATASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  61
GLN A 120
ILE A 182
THR A 180
 None
 1.00A 6cduF-3wewA:
undetectable
6cduG-3wewA:
undetectable		 6cduF-3wewA:
19.82
6cduG-3wewA:
19.82