SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wfj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3wfj 2-DEHYDROPANTOATE
2-REDUCTASE
(Enterococcus
faecium) 		5 / 12 GLY A 137
ASN A  47
LEU A  17
ILE A  39
LEU A  57
 None
 1.16A 1lhuA-3wfjA:
undetectable		 1lhuA-3wfjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3wfj 2-DEHYDROPANTOATE
2-REDUCTASE
(Enterococcus
faecium) 		4 / 7 GLY A 143
PHE A  48
ASN A  47
ARG A  14
 None
 0.92A 1oniG-3wfjA:
undetectable
1oniI-3wfjA:
undetectable		 1oniG-3wfjA:
21.00
1oniI-3wfjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3wfj 2-DEHYDROPANTOATE
2-REDUCTASE
(Enterococcus
faecium) 		5 / 12 VAL A 139
ILE A   5
GLY A   9
ALA A  10
LEU A 141
 None
None
NAD  A 401 (-3.0A)
NAD  A 401 (-3.1A)
None
 0.93A 1r9oA-3wfjA:
undetectable		 1r9oA-3wfjA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 3wfj 2-DEHYDROPANTOATE
2-REDUCTASE
(Enterococcus
faecium) 		5 / 12 ALA A  10
GLY A  12
GLY A   9
GLN A  82
ASP A  30
 NAD  A 401 (-3.1A)
None
NAD  A 401 (-3.0A)
NAD  A 401 (-3.3A)
NAD  A 401 (-2.7A)
 1.16A 2c49A-3wfjA:
5.0		 2c49A-3wfjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3wfj 2-DEHYDROPANTOATE
2-REDUCTASE
(Enterococcus
faecium) 		4 / 8 LEU A 103
ILE A  75
ARG A  14
GLY A  16
 None
 0.94A 3b9lA-3wfjA:
2.3		 3b9lA-3wfjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wfj 2-DEHYDROPANTOATE
2-REDUCTASE
(Enterococcus
faecium) 		5 / 12 GLY A   9
ALA A  10
SER A  13
GLY A  16
LEU A  17
 NAD  A 401 (-3.0A)
NAD  A 401 (-3.1A)
None
None
None
 0.90A 4e1gA-3wfjA:
undetectable		 4e1gA-3wfjA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wfj 2-DEHYDROPANTOATE
2-REDUCTASE
(Enterococcus
faecium) 		5 / 12 GLY A   9
ALA A  10
SER A  13
GLY A  16
LEU A  17
 NAD  A 401 (-3.0A)
NAD  A 401 (-3.1A)
None
None
None
 0.92A 4e1gB-3wfjA:
undetectable		 4e1gB-3wfjA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 3wfj 2-DEHYDROPANTOATE
2-REDUCTASE
(Enterococcus
faecium) 		4 / 6 ASP A 264
GLU A 306
ILE A 107
PRO A 259
 None
 0.98A 4xi3C-3wfjA:
undetectable		 4xi3C-3wfjA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3wfj 2-DEHYDROPANTOATE
2-REDUCTASE
(Enterococcus
faecium) 		4 / 7 MET A 261
GLY A 279
ASN A 278
HIS A 303
 None
 1.27A 5a5zC-3wfjA:
undetectable		 5a5zC-3wfjA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 3wfj 2-DEHYDROPANTOATE
2-REDUCTASE
(Enterococcus
faecium) 		4 / 5 VAL A 302
THR A 199
ASP A 264
LEU A 265
 None
 1.27A 5m0iB-3wfjA:
undetectable		 5m0iB-3wfjA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3wfj 2-DEHYDROPANTOATE
2-REDUCTASE
(Enterococcus
faecium) 		5 / 12 LEU A  83
THR A  78
GLY A   7
VAL A 117
ILE A 122
 None
None
NAD  A 401 ( 4.6A)
None
None
 1.44A 5tuiB-3wfjA:
4.0		 5tuiB-3wfjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3wfj 2-DEHYDROPANTOATE
2-REDUCTASE
(Enterococcus
faecium) 		5 / 9 ASP A 264
SER A 260
GLY A 108
ASN A 191
ILE A 107
 None
 1.30A 6giqA-3wfjA:
1.8
6giqE-3wfjA:
undetectable
6giqI-3wfjA:
undetectable		 6giqA-3wfjA:
21.48
6giqE-3wfjA:
20.57
6giqI-3wfjA:
11.67