SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wfl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		5 / 12 GLU A 308
ILE A 139
LEU A 198
ASP A 269
LEU A 231
 None
 1.13A 1hvyD-3wflA:
undetectable		 1hvyD-3wflA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		3 / 3 GLU A 309
ASN A  57
TRP A  88
 TRS  A 402 (-2.8A)
None
GOL  A 404 (-4.0A)
 1.17A 1r15C-3wflA:
1.9		 1r15C-3wflA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		3 / 3 GLU A 309
ASN A  57
TRP A  88
 TRS  A 402 (-2.8A)
None
GOL  A 404 (-4.0A)
 1.22A 1r15D-3wflA:
1.9		 1r15D-3wflA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		3 / 3 GLU A 309
ASN A  57
TRP A  88
 TRS  A 402 (-2.8A)
None
GOL  A 404 (-4.0A)
 1.19A 1r15E-3wflA:
undetectable		 1r15E-3wflA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		3 / 3 GLU A 309
ASN A  57
TRP A  88
 TRS  A 402 (-2.8A)
None
GOL  A 404 (-4.0A)
 1.19A 1r15F-3wflA:
2.0		 1r15F-3wflA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		5 / 12 ASP A 236
HIS A 294
GLY A 238
PHE A 259
TYR A 253
 None
None
None
None
NAG  A 401 (-3.6A)
 1.47A 1t69A-3wflA:
undetectable		 1t69A-3wflA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 7 GLN A 340
TYR A 276
TRP A  88
GLU A 201
 None
TRS  A 402 (-4.5A)
GOL  A 404 (-4.0A)
TRS  A 402 (-2.7A)
 1.25A 2aowA-3wflA:
1.8		 2aowA-3wflA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 7 ASP A 246
PHE A 286
PRO A 289
THR A 292
 None
 1.48A 2q6kA-3wflA:
undetectable		 2q6kA-3wflA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		6 / 12 ASN A 200
GLU A 201
HIS A 274
TYR A 276
GLU A 309
TRP A 339
 TRS  A 402 (-2.7A)
TRS  A 402 (-2.7A)
None
TRS  A 402 (-4.5A)
TRS  A 402 (-2.8A)
TRS  A 402 ( 3.7A)
 0.86A 2v3dA-3wflA:
7.5		 2v3dA-3wflA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 8 GLY A 287
PHE A 270
PHE A 273
PHE A 259
 None
 0.60A 3ko0D-3wflA:
undetectable
3ko0E-3wflA:
undetectable		 3ko0D-3wflA:
13.24
3ko0E-3wflA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 8 PHE A 273
PHE A 259
GLY A 287
PHE A 270
 None
 0.71A 3ko0B-3wflA:
undetectable
3ko0J-3wflA:
undetectable		 3ko0B-3wflA:
13.24
3ko0J-3wflA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 7 GLY A 287
PHE A 270
PHE A 273
PHE A 259
 None
 0.60A 3ko0L-3wflA:
undetectable
3ko0N-3wflA:
undetectable		 3ko0L-3wflA:
13.24
3ko0N-3wflA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 7 GLY A 287
PHE A 270
PHE A 273
PHE A 259
 None
 0.72A 3ko0M-3wflA:
undetectable
3ko0P-3wflA:
undetectable		 3ko0M-3wflA:
13.24
3ko0P-3wflA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 8 GLY A 287
PHE A 270
PHE A 273
PHE A 259
 None
 0.66A 3ko0O-3wflA:
undetectable
3ko0Q-3wflA:
undetectable		 3ko0O-3wflA:
13.24
3ko0Q-3wflA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 7 PHE A 273
PHE A 259
GLY A 287
PHE A 270
 None
 0.69A 3ko0K-3wflA:
undetectable
3ko0S-3wflA:
undetectable		 3ko0K-3wflA:
13.24
3ko0S-3wflA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 7 PHE A 273
PHE A 259
GLY A 287
PHE A 270
 None
 0.62A 3ko0R-3wflA:
undetectable
3ko0T-3wflA:
undetectable		 3ko0R-3wflA:
13.24
3ko0T-3wflA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		5 / 9 GLY A 302
ALA A 301
GLY A 295
ILE A 333
LEU A 263
 None
 0.90A 3ogpB-3wflA:
undetectable		 3ogpB-3wflA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 7 TYR A 187
LEU A 121
ALA A  62
TYR A 179
 None
 1.17A 3rodD-3wflA:
undetectable		 3rodD-3wflA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		5 / 11 GLN A 325
SER A 288
PHE A 307
TYR A  52
ILE A 333
 None
 1.42A 4claA-3wflA:
undetectable		 4claA-3wflA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		5 / 12 GLU A 308
ILE A 139
LEU A 198
ASP A 269
LEU A 231
 None
 1.16A 4foxA-3wflA:
undetectable		 4foxA-3wflA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		5 / 12 GLU A 308
ILE A 139
LEU A 198
ASP A 269
LEU A 231
 None
 1.17A 4foxB-3wflA:
undetectable		 4foxB-3wflA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		5 / 12 GLU A 308
ILE A 139
LEU A 198
ASP A 269
LEU A 231
 None
 1.11A 4foxG-3wflA:
undetectable		 4foxG-3wflA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 6 THR A  45
PRO A  37
ARG A  83
PHE A 194
 None
None
GOL  A 405 ( 4.0A)
None
 1.30A 4kf9A-3wflA:
undetectable		 4kf9A-3wflA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		3 / 3 TYR A 149
GLN A 340
TRP A 146
 None
 0.91A 4kn2C-3wflA:
undetectable		 4kn2C-3wflA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 6 ASN A 200
GLU A 197
GLU A 201
GLU A 237
 TRS  A 402 (-2.7A)
None
TRS  A 402 (-2.7A)
None
 1.46A 4mi4A-3wflA:
undetectable		 4mi4A-3wflA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		5 / 12 GLY A 151
PHE A 142
ASN A 145
ALA A 154
ASN A 157
 None
 1.32A 4pclB-3wflA:
2.6		 4pclB-3wflA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		3 / 3 THR A  39
THR A  45
PHE A  36
 None
 0.80A 5cxvA-3wflA:
undetectable		 5cxvA-3wflA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 6 PHE A 270
SER A 288
VAL A 291
ASP A 336
 None
 1.28A 5hesA-3wflA:
undetectable		 5hesA-3wflA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		3 / 3 GLY A 235
ASP A 236
ASN A 258
 None
None
NAG  A 401 (-1.9A)
 0.58A 5jglA-3wflA:
undetectable		 5jglA-3wflA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 8 ARG A 203
GLU A 237
PRO A 250
GLY A 240
 None
 1.13A 5kgpB-3wflA:
undetectable		 5kgpB-3wflA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3wfl BETA-MANNANASE
(Talaromyces
trachyspermus) 		4 / 6 LEU A 107
ALA A 154
SER A 172
ASN A 141
 None
 0.89A 6f88A-3wflA:
undetectable		 6f88A-3wflA:
12.65