SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wfo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 125
ILE A 139
ALA A 140
VAL A  44
LEU A  31
 None
 0.99A 1cbsA-3wfoA:
undetectable		 1cbsA-3wfoA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 GLU A  86
ILE A  97
ARG A 132
 None
 0.73A 1cd2A-3wfoA:
undetectable		 1cd2A-3wfoA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 8 ASP A 326
HIS A 325
HIS A 377
HIS A 276
 None
 0.91A 1ei6D-3wfoA:
undetectable		 1ei6D-3wfoA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 6 VAL A 239
ILE A 240
TRP A 320
LEU A 360
 None
 1.26A 1j96A-3wfoA:
undetectable		 1j96A-3wfoA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 8 THR A 135
ASN A 137
ASP A 133
GLU A 226
 None
SO4  A 601 ( 4.9A)
None
None
 1.13A 1mxgA-3wfoA:
undetectable		 1mxgA-3wfoA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 12 ALA A 193
ILE A 192
VAL A 239
ALA A 236
LEU A 227
 None
 1.10A 1udtA-3wfoA:
8.3		 1udtA-3wfoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 VAL A  59
VAL A  40
TRP A  43
 None
 0.94A 1w5uA-3wfoA:
undetectable
1w5uB-3wfoA:
undetectable		 1w5uA-3wfoA:
4.26
1w5uB-3wfoA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 8 LEU A 284
HIS A 325
HIS A 276
ALA A 417
 None
 1.03A 2bnnA-3wfoA:
undetectable
2bnnB-3wfoA:
undetectable		 2bnnA-3wfoA:
17.15
2bnnB-3wfoA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 125
ILE A 139
ALA A 140
VAL A  44
LEU A  31
 None
 1.06A 2fr3A-3wfoA:
undetectable		 2fr3A-3wfoA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 125
ILE A 139
ALA A 140
VAL A  44
LEU A  31
 None
 1.01A 2g78A-3wfoA:
undetectable		 2g78A-3wfoA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 VAL A  40
TRP A  43
VAL A  59
 None
 0.96A 2izqC-3wfoA:
undetectable
2izqD-3wfoA:
undetectable		 2izqC-3wfoA:
4.26
2izqD-3wfoA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 7 ILE A 240
ARG A 241
TYR A 244
GLU A 275
 None
 1.06A 2qebA-3wfoA:
undetectable		 2qebA-3wfoA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 7 ILE A 240
ARG A 241
TYR A 244
GLU A 275
 None
 1.04A 2qebB-3wfoA:
undetectable		 2qebB-3wfoA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 10 ASP A 158
ILE A 139
VAL A 141
LEU A  14
PHE A  19
 None
 1.40A 3ay0A-3wfoA:
undetectable		 3ay0A-3wfoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 4 ARG A 185
ASP A  58
ASP A  60
ASP A 112
 None
 1.25A 3naiB-3wfoA:
0.8		 3naiB-3wfoA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 6 LEU A 392
ALA A 431
ASP A 428
THR A 435
 None
 1.12A 3rozA-3wfoA:
undetectable		 3rozA-3wfoA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 7 TRP A  43
PHE A 113
VAL A  27
PHE A  24
 None
 0.95A 3zjqA-3wfoA:
1.6		 3zjqA-3wfoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 7 TRP A  43
PHE A 113
VAL A  27
PHE A  24
 None
 0.95A 3zjqB-3wfoA:
undetectable		 3zjqB-3wfoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 181
GLU A 131
ASN A 178
 None
 0.82A 4imaD-3wfoA:
undetectable		 4imaD-3wfoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 181
GLU A 131
ASN A 178
 None
 0.85A 4ip7D-3wfoA:
undetectable		 4ip7D-3wfoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 143
CYH A  37
PHE A  61
ASP A 112
GLY A  42
 None
None
None
None
SO4  A 601 ( 4.3A)
 1.34A 4j7xF-3wfoA:
undetectable		 4j7xF-3wfoA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 9 MET A 231
VAL A 353
ILE A 356
LEU A 360
ILE A 327
 None
 1.07A 4kukA-3wfoA:
undetectable		 4kukA-3wfoA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 9 ILE A 176
PHE A 134
LEU A 179
LEU A 200
PHE A 190
 None
 1.43A 4qopA-3wfoA:
undetectable		 4qopA-3wfoA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 9 ILE A 176
PHE A 134
LEU A 179
LEU A 200
PHE A 190
 None
 1.43A 4qopB-3wfoA:
undetectable		 4qopB-3wfoA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 12 ILE A 436
PHE A 303
LEU A 318
LEU A 373
LEU A 411
 None
 1.29A 4xumA-3wfoA:
undetectable		 4xumA-3wfoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 ASP A  58
GLU A 195
SER A 114
 None
SO4  A 601 ( 4.4A)
None
 0.69A 5bw4B-3wfoA:
undetectable		 5bw4B-3wfoA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 4 LEU A 360
ILE A 356
PRO A 254
LEU A 249
 None
 0.96A 5eb3A-3wfoA:
undetectable		 5eb3A-3wfoA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 6 ILE A 356
ALA A 366
THR A 367
VAL A 370
 None
 0.55A 5eclD-3wfoA:
undetectable		 5eclD-3wfoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 8 ILE A 356
ALA A 366
THR A 367
VAL A 370
 None
 0.60A 5ecnD-3wfoA:
undetectable		 5ecnD-3wfoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 9 ILE A 252
GLU A 255
ARG A 258
ILE A 256
GLY A 257
 None
 1.22A 5ifuB-3wfoA:
undetectable		 5ifuB-3wfoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 12 GLU A 167
LEU A  49
ASP A 158
GLY A 162
LEU A 171
 SO4  A 603 (-4.5A)
None
None
None
None
 1.30A 5kc4E-3wfoA:
undetectable		 5kc4E-3wfoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 162
LEU A 198
GLY A 189
GLY A  41
ILE A  48
 None
None
None
None
SO4  A 603 (-4.9A)
 1.12A 5tuiB-3wfoA:
undetectable		 5tuiB-3wfoA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 12 ILE A  48
GLY A 162
THR A 160
LEU A 129
PHE A  38
 SO4  A 603 (-4.9A)
None
None
None
None
 1.18A 5v5zA-3wfoA:
undetectable		 5v5zA-3wfoA:
25.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		3 / 3 GLU A 206
ASP A 211
PRO A 212
 None
 0.56A 6berA-3wfoA:
undetectable		 6berA-3wfoA:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		5 / 12 ILE A  48
GLY A 162
THR A 160
LEU A 129
PHE A  38
 SO4  A 603 (-4.9A)
None
None
None
None
 1.21A 6e8qA-3wfoA:
undetectable		 6e8qA-3wfoA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 8 ASP A 133
HIS A 225
GLU A 226
GLU A 195
 None
None
None
SO4  A 601 ( 4.4A)
 1.08A 6mn4A-3wfoA:
undetectable		 6mn4A-3wfoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 8 ASP A 133
HIS A 225
GLU A 226
GLU A 195
 None
None
None
SO4  A 601 ( 4.4A)
 0.99A 6mn4B-3wfoA:
undetectable		 6mn4B-3wfoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3wfo POLY A POLYMERASE
(Aquifex
aeolicus) 		4 / 8 ASP A 133
HIS A 225
GLU A 226
GLU A 195
 None
None
None
SO4  A 601 ( 4.4A)
 0.92A 6mn4D-3wfoA:
undetectable		 6mn4D-3wfoA:
18.98