SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wfp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		5 / 12 LEU A 125
ILE A 139
ALA A 140
VAL A  44
LEU A  31
 None
 1.07A 1cbsA-3wfpA:
undetectable		 1cbsA-3wfpA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		4 / 8 ASP A 326
HIS A 325
HIS A 377
HIS A 276
 None
 1.01A 1ei6D-3wfpA:
undetectable		 1ei6D-3wfpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		4 / 6 VAL A 239
ILE A 240
TRP A 320
LEU A 360
 None
 1.25A 1j96A-3wfpA:
undetectable		 1j96A-3wfpA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		4 / 8 THR A 135
ASN A 137
ASP A 133
GLU A 226
 None
SO4  A1001 ( 4.5A)
None
None
 1.21A 1mxgA-3wfpA:
undetectable		 1mxgA-3wfpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		4 / 7 LYS A 196
LEU A  49
GLU A 195
ALA A 136
 None
 1.03A 1sn0B-3wfpA:
undetectable
1sn0D-3wfpA:
undetectable		 1sn0B-3wfpA:
15.53
1sn0D-3wfpA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		3 / 3 VAL A  59
VAL A  40
TRP A  43
 None
 0.92A 1w5uA-3wfpA:
undetectable
1w5uB-3wfpA:
undetectable		 1w5uA-3wfpA:
2.75
1w5uB-3wfpA:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		5 / 12 THR A 280
ASP A 346
LEU A 411
LEU A 414
GLY A 321
 None
 1.22A 1xwfA-3wfpA:
undetectable		 1xwfA-3wfpA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		5 / 12 LEU A 125
ILE A 139
ALA A 140
VAL A  44
LEU A  31
 None
 1.10A 2g78A-3wfpA:
undetectable		 2g78A-3wfpA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		3 / 3 VAL A  40
TRP A  43
VAL A  59
 None
 0.97A 2izqC-3wfpA:
undetectable
2izqD-3wfpA:
undetectable		 2izqC-3wfpA:
2.75
2izqD-3wfpA:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		4 / 6 ARG A 172
ASP A 203
THR A 201
ASP A 165
 None
 1.27A 2j2pE-3wfpA:
undetectable
2j2pF-3wfpA:
undetectable		 2j2pE-3wfpA:
16.16
2j2pF-3wfpA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		4 / 7 ILE A 240
ARG A 241
TYR A 244
GLU A 275
 None
 1.08A 2qebA-3wfpA:
undetectable		 2qebA-3wfpA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		4 / 7 ILE A 240
ARG A 241
TYR A 244
GLU A 275
 None
 1.06A 2qebB-3wfpA:
undetectable		 2qebB-3wfpA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		5 / 12 ASP A  46
GLY A 162
GLY A 161
THR A 135
LEU A 198
 SO4  A1001 ( 4.7A)
None
None
None
None
 0.97A 2uvnA-3wfpA:
undetectable		 2uvnA-3wfpA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		5 / 12 LEU A 227
LEU A 243
ILE A 256
GLU A 255
PHE A 324
 None
 1.04A 2weyA-3wfpA:
7.9		 2weyA-3wfpA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		5 / 10 PHE A 113
SER A 114
ALA A  65
LEU A  70
ALA A  71
 None
 1.44A 2wscB-3wfpA:
undetectable		 2wscB-3wfpA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		5 / 10 PHE A 113
SER A 114
ALA A  65
LEU A  70
ALA A  71
 None
 1.44A 2wseB-3wfpA:
undetectable		 2wseB-3wfpA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		5 / 9 PHE A 113
SER A 114
ALA A  65
LEU A  70
ALA A  71
 None
 1.43A 2wsfB-3wfpA:
undetectable		 2wsfB-3wfpA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		5 / 10 PHE A 113
SER A 114
ALA A  65
LEU A  70
ALA A  71
 None
 1.42A 3lw5B-3wfpA:
undetectable		 3lw5B-3wfpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		4 / 7 TRP A  43
PHE A 113
VAL A  27
PHE A  24
 None
 0.91A 3zjqA-3wfpA:
undetectable		 3zjqA-3wfpA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		4 / 7 TRP A  43
PHE A 113
VAL A  27
PHE A  24
 None
 0.90A 3zjqB-3wfpA:
undetectable		 3zjqB-3wfpA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		3 / 3 ARG A 181
GLU A 131
ASN A 178
 None
 0.82A 4imaD-3wfpA:
undetectable		 4imaD-3wfpA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		3 / 3 ARG A 181
GLU A 131
ASN A 178
 None
 0.84A 4ip7D-3wfpA:
undetectable		 4ip7D-3wfpA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		5 / 9 MET A 231
VAL A 353
ILE A 356
LEU A 360
ILE A 327
 None
 1.06A 4kukA-3wfpA:
undetectable		 4kukA-3wfpA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		4 / 6 ARG A  45
ARG A 188
ARG A 132
ASP A 133
 SO4  A1001 (-2.8A)
SO4  A1001 (-3.6A)
None
None
 1.39A 4xqeB-3wfpA:
undetectable		 4xqeB-3wfpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		3 / 3 ASP A  58
GLU A 195
SER A 114
 SO4  A1001 ( 4.7A)
None
None
 0.71A 5bw4B-3wfpA:
undetectable		 5bw4B-3wfpA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		4 / 4 LEU A 360
ILE A 356
PRO A 254
LEU A 249
 None
 0.96A 5eb3A-3wfpA:
undetectable		 5eb3A-3wfpA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		4 / 6 ILE A 356
ALA A 366
THR A 367
VAL A 370
 None
 0.59A 5eclD-3wfpA:
2.0		 5eclD-3wfpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		4 / 8 ILE A 356
ALA A 366
THR A 367
VAL A 370
 None
 0.58A 5ecnD-3wfpA:
undetectable		 5ecnD-3wfpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		3 / 3 HIS A 345
ASP A 346
HIS A 377
 None
 0.78A 5oexB-3wfpA:
undetectable		 5oexB-3wfpA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		3 / 3 HIS A 345
ASP A 346
HIS A 377
 None
 0.76A 5oexC-3wfpA:
undetectable		 5oexC-3wfpA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		3 / 3 HIS A 345
ASP A 346
HIS A 377
 None
 0.73A 5oexD-3wfpA:
undetectable		 5oexD-3wfpA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		5 / 12 GLY A 162
LEU A 198
GLY A 189
GLY A  41
ILE A  48
 None
 1.15A 5tuiB-3wfpA:
undetectable		 5tuiB-3wfpA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		5 / 12 ILE A  48
GLY A 162
THR A 160
LEU A 129
PHE A  38
 None
 1.15A 5v5zA-3wfpA:
undetectable		 5v5zA-3wfpA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		3 / 3 TYR A 343
LEU A 378
ASP A 418
 None
 0.86A 5zv2B-3wfpA:
undetectable		 5zv2B-3wfpA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		3 / 3 GLU A 206
ASP A 211
PRO A 212
 None
 0.77A 6berA-3wfpA:
undetectable		 6berA-3wfpA:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 3wfp POLY A POLYMERASE
(Aquifex
aeolicus;
synthetic
construct) 		3 / 3 ARG A 188
ARG A 110
ARG A 222
 SO4  A1001 (-3.6A)
None
None
 1.10A 6bplA-3wfpA:
undetectable
6bplB-3wfpA:
undetectable		 6bplA-3wfpA:
14.08
6bplB-3wfpA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		5 / 12 ILE A  48
GLY A 162
THR A 160
LEU A 129
PHE A  38
 None
 1.19A 6e8qA-3wfpA:
undetectable		 6e8qA-3wfpA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		4 / 8 ASP A 133
HIS A 225
GLU A 226
GLU A 195
 None
 1.14A 6mn4A-3wfpA:
undetectable		 6mn4A-3wfpA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		4 / 8 ASP A 133
HIS A 225
GLU A 226
GLU A 195
 None
 1.03A 6mn4B-3wfpA:
undetectable		 6mn4B-3wfpA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		4 / 8 ASP A 133
HIS A 225
GLU A 226
GLU A 195
 None
 0.98A 6mn4D-3wfpA:
undetectable		 6mn4D-3wfpA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		5 / 11 LEU A 414
ALA A 417
PHE A 381
ALA A 421
HIS A 276
 None
 1.46A 6qgbA-3wfpA:
undetectable		 6qgbA-3wfpA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3wfp POLY A POLYMERASE
(synthetic
construct;
Aquifex
aeolicus) 		5 / 11 LEU A 414
ALA A 417
PHE A 381
ALA A 421
HIS A 276
 None
 1.46A 6qgbE-3wfpA:
undetectable		 6qgbE-3wfpA:
17.14