SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 10 GLY A 357
VAL A 334
ARG A 396
ARG A  32
GLY A 398
 None
 1.40A 1fohA-3wfzA:
undetectable		 1fohA-3wfzA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 10 GLY A 357
VAL A 334
ARG A 396
ARG A  32
GLY A 398
 None
 1.40A 1fohB-3wfzA:
undetectable		 1fohB-3wfzA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 10 GLY A 357
VAL A 334
ARG A 396
ARG A  32
GLY A 398
 None
 1.44A 1fohC-3wfzA:
undetectable		 1fohC-3wfzA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 10 GLY A 357
VAL A 334
ARG A 396
ARG A  32
GLY A 398
 None
 1.44A 1fohD-3wfzA:
undetectable		 1fohD-3wfzA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 7 SER A 478
GLY A 338
THR A 342
ILE A 337
 None
 0.95A 1gtnF-3wfzA:
undetectable
1gtnG-3wfzA:
undetectable		 1gtnF-3wfzA:
7.65
1gtnG-3wfzA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 7 SER A 478
GLY A 338
THR A 342
ILE A 337
 None
 0.95A 1gtnJ-3wfzA:
undetectable
1gtnK-3wfzA:
undetectable		 1gtnJ-3wfzA:
7.65
1gtnK-3wfzA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 GLU A 356
ARG A 396
ILE A 394
ILE A 389
ALA A 385
 None
 1.10A 1kijB-3wfzA:
undetectable		 1kijB-3wfzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 7 GLU A 475
PHE A 234
MET A 345
ALA A 347
 None
 1.24A 1linA-3wfzA:
undetectable		 1linA-3wfzA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 11 ALA A 435
HIS A 708
GLU A 705
ARG A 387
GLU A 681
 None
 1.30A 1mjlA-3wfzA:
undetectable
1mjlB-3wfzA:
undetectable		 1mjlA-3wfzA:
8.54
1mjlB-3wfzA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 7 GLU A 422
ILE A 718
TRP A 382
LEU A 379
 None
 1.48A 1q0yH-3wfzA:
undetectable
1q0yL-3wfzA:
undetectable		 1q0yH-3wfzA:
14.15
1q0yL-3wfzA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 PRO A 671
ILE A 588
ILE A 667
THR A 589
PHE A 587
 None
 1.24A 1sg9A-3wfzA:
undetectable		 1sg9A-3wfzA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 6 ALA A 548
SER A 547
THR A 515
ASN A 506
 None
 0.98A 1yvpB-3wfzA:
undetectable		 1yvpB-3wfzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 GLY A 564
ASN A 641
ASP A 566
GLY A 541
PHE A 539
 None
 1.07A 2f8lA-3wfzA:
undetectable		 2f8lA-3wfzA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 8 ARG A 358
THR A 343
GLY A 335
THR A 355
ILE A 394
 None
 1.43A 2f9wA-3wfzA:
2.1
2f9wB-3wfzA:
undetectable		 2f9wA-3wfzA:
16.42
2f9wB-3wfzA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 VAL A 116
TRP A 129
VAL A 151
 None
 0.95A 2izqA-3wfzA:
undetectable
2izqB-3wfzA:
undetectable		 2izqA-3wfzA:
1.68
2izqB-3wfzA:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 7 GLY A 516
VAL A 529
SER A 546
LEU A 559
 None
 0.65A 2oa1B-3wfzA:
undetectable		 2oa1B-3wfzA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 6 GLY A 378
GLY A 398
PHE A 363
PHE A 368
 None
 1.04A 2qx6A-3wfzA:
undetectable
2qx6B-3wfzA:
3.6		 2qx6A-3wfzA:
16.33
2qx6B-3wfzA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 11 ALA A 677
VAL A 683
GLY A 472
ILE A 473
VAL A 540
 None
 0.95A 2uxpB-3wfzA:
0.8		 2uxpB-3wfzA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 7 PHE A  96
PHE A 153
ILE A  90
GLY A 265
 None
 1.02A 2v0mC-3wfzA:
undetectable		 2v0mC-3wfzA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 ILE A 505
ASN A 676
VAL A 441
VAL A 683
THR A 589
 None
 1.05A 2vn0A-3wfzA:
undetectable		 2vn0A-3wfzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 PRO A 671
GLY A 629
TYR A 468
 None
 0.72A 2vouB-3wfzA:
undetectable		 2vouB-3wfzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 PRO A 671
GLY A 629
TYR A 468
 None
 0.72A 2vouC-3wfzA:
undetectable		 2vouC-3wfzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 8 GLY A 448
ASN A 445
VAL A 542
SER A 452
 None
 0.93A 2yoeB-3wfzA:
undetectable
2yoeC-3wfzA:
undetectable		 2yoeB-3wfzA:
18.57
2yoeC-3wfzA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 PRO A 350
GLU A 319
TYR A 321
 None
 0.67A 2zmbA-3wfzA:
undetectable		 2zmbA-3wfzA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 11 LEU A  22
GLY A  27
ALA A  28
ASP A  29
ILE A 419
 None
 1.11A 3ektD-3wfzA:
undetectable		 3ektD-3wfzA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 8 ASP A 283
ASP A 280
ASP A 323
ASP A 491
 None
 1.11A 3havA-3wfzA:
undetectable		 3havA-3wfzA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 ILE A 667
LEU A 684
ILE A 473
SER A 476
LEU A 477
 None
 1.10A 3k2hB-3wfzA:
undetectable		 3k2hB-3wfzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 10 ARG A 275
ASN A 268
GLY A 235
GLY A 264
ALA A 266
 None
 1.12A 3pp7B-3wfzA:
10.2		 3pp7B-3wfzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 10 THR A 342
PRO A 463
GLY A 472
GLY A 338
ALA A 461
 None
 1.39A 3pp7B-3wfzA:
10.2		 3pp7B-3wfzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 TYR A 399
GLU A  12
TYR A 402
 None
 0.98A 3ug8A-3wfzA:
8.0		 3ug8A-3wfzA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 THR A 150
VAL A 116
GLU A 148
 None
 0.76A 3v4tA-3wfzA:
undetectable
3v4tD-3wfzA:
undetectable		 3v4tA-3wfzA:
20.42
3v4tD-3wfzA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 6 ILE A 157
LEU A 101
ARG A  58
MET A 164
 None
 1.12A 3wg7A-3wfzA:
undetectable
3wg7J-3wfzA:
undetectable		 3wg7A-3wfzA:
20.23
3wg7J-3wfzA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 ARG A 118
ARG A 257
ASP A 263
 None
 0.94A 3wipG-3wfzA:
undetectable
3wipH-3wfzA:
undetectable		 3wipG-3wfzA:
15.59
3wipH-3wfzA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 VAL A 492
ILE A 504
ILE A 563
SER A 546
LEU A 525
 None
 1.21A 4a84A-3wfzA:
undetectable		 4a84A-3wfzA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 11 ARG A 257
VAL A 115
GLU A 114
GLU A 259
VAL A 140
 None
 1.29A 4d9hA-3wfzA:
undetectable		 4d9hA-3wfzA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 11 ARG A 257
VAL A 115
GLU A 114
GLU A 259
VAL A 140
 None
 1.29A 4danA-3wfzA:
undetectable		 4danA-3wfzA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 ASP A 260
ARG A 257
ASP A 280
 None
 0.61A 4fp9A-3wfzA:
undetectable		 4fp9A-3wfzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 ASP A 260
ARG A 257
ASP A 280
 None
 0.60A 4fp9C-3wfzA:
undetectable		 4fp9C-3wfzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 ASP A 260
ARG A 257
ASP A 280
 None
 0.64A 4fp9F-3wfzA:
undetectable		 4fp9F-3wfzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 ARG A 663
HIS A 689
TYR A 686
 None
 1.17A 4fu8A-3wfzA:
undetectable		 4fu8A-3wfzA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 ARG A 663
HIS A 689
TYR A 686
 None
 1.15A 4fu9A-3wfzA:
undetectable		 4fu9A-3wfzA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 5 PRO A  72
ASP A 182
ILE A  64
VAL A 192
 None
 1.20A 4hytA-3wfzA:
undetectable		 4hytA-3wfzA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 8 ALA A 747
LEU A 741
TYR A 715
ARG A 749
 None
 1.00A 4ijiF-3wfzA:
undetectable		 4ijiF-3wfzA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 7 ALA A 747
VAL A 729
TYR A 715
ARG A 749
 None
 1.06A 4ijiH-3wfzA:
undetectable		 4ijiH-3wfzA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 6 PHE A 325
LEU A 311
VAL A 333
VAL A 293
 None
 1.17A 4kkyX-3wfzA:
undetectable		 4kkyX-3wfzA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 LEU A 741
PRO A 742
ARG A 429
 None
 0.63A 4klrB-3wfzA:
undetectable		 4klrB-3wfzA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 9 LEU A  22
GLY A  27
ALA A  28
ASP A  29
ILE A 419
 None
 1.17A 4njtD-3wfzA:
undetectable		 4njtD-3wfzA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 ASN A 720
GLY A 340
SER A 478
ILE A 394
GLY A 357
 None
 1.22A 4obwA-3wfzA:
undetectable		 4obwA-3wfzA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 ASP A 331
LYS A 305
LEU A 200
 None
 1.07A 4ptjA-3wfzA:
undetectable		 4ptjA-3wfzA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 6 GLU A 544
TYR A 666
THR A 635
TYR A 470
 None
 1.33A 4qwpA-3wfzA:
undetectable		 4qwpA-3wfzA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 9 ALA A 347
TYR A 471
GLY A 340
ALA A 388
VAL A 484
 None
 1.22A 4r1zA-3wfzA:
undetectable		 4r1zA-3wfzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 5 ALA A 677
GLU A 705
ASN A 720
GLU A 703
 None
 1.44A 5dwkC-3wfzA:
undetectable		 5dwkC-3wfzA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 ALA A 407
LEU A  22
ILE A 426
GLY A 745
LEU A 379
 None
 1.12A 5eshA-3wfzA:
undetectable		 5eshA-3wfzA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 MET A 345
HIS A 460
GLY A 335
 None
NDG  A4001 ( 4.0A)
None
 0.85A 5gwzB-3wfzA:
undetectable		 5gwzB-3wfzA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 ILE A 179
PRO A 180
ILE A  64
 None
 0.41A 5hw8F-3wfzA:
undetectable		 5hw8F-3wfzA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 7 GLY A  27
ALA A  28
ASP A  29
GLY A 398
 None
 0.64A 5kqyB-3wfzA:
undetectable		 5kqyB-3wfzA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 8 GLY A  27
ALA A  28
ASP A  29
GLY A 398
 None
 0.66A 5kr1B-3wfzA:
undetectable		 5kr1B-3wfzA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 VAL A 632
LEU A 679
ASP A 627
PRO A 545
GLY A 507
 None
 1.24A 5syeB-3wfzA:
undetectable		 5syeB-3wfzA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 GLY A 516
TYR A 470
ASN A 506
PHE A 557
GLN A 558
 None
 1.49A 5ttfB-3wfzA:
undetectable		 5ttfB-3wfzA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 5 ARG A 485
PHE A 539
LEU A 444
LEU A 684
 None
 0.97A 5veuH-3wfzA:
undetectable		 5veuH-3wfzA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 PHE A 214
HIS A 301
LEU A 200
PHE A 211
LEU A 330
 None
 1.31A 5y2oA-3wfzA:
undetectable		 5y2oA-3wfzA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 ASP A 182
PHE A 288
ARG A 189
 None
 1.06A 5yw0A-3wfzA:
undetectable		 5yw0A-3wfzA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 MET A 450
ASP A 283
ARG A 275
 None
 0.84A 5z6jA-3wfzA:
undetectable		 5z6jA-3wfzA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 MET A 450
ASP A 283
ARG A 275
 None
 0.98A 5z6kA-3wfzA:
undetectable		 5z6kA-3wfzA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		3 / 3 TYR A 399
ARG A 358
THR A   8
 None
 0.96A 5z84J-3wfzA:
undetectable		 5z84J-3wfzA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 ALA A 677
GLY A 340
ASP A 591
ARG A 682
TYR A 694
 None
 1.30A 5zvgA-3wfzA:
undetectable		 5zvgA-3wfzA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 10 LEU A 680
VAL A 665
VAL A 542
GLY A 541
LEU A 684
 None
 1.40A 6bsgA-3wfzA:
undetectable		 6bsgA-3wfzA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 10 LEU A 680
VAL A 665
VAL A 542
GLY A 541
LEU A 684
 None
 1.40A 6bsiA-3wfzA:
undetectable		 6bsiA-3wfzA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 VAL A 519
THR A 521
ALA A 548
ASN A 506
VAL A 529
 None
 1.34A 6drxA-3wfzA:
undetectable		 6drxA-3wfzA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		4 / 6 LEU A 462
ALA A 459
THR A 169
ASN A 166
 None
None
None
NDG  A4001 ( 4.6A)
 0.94A 6f88A-3wfzA:
undetectable		 6f88A-3wfzA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 11 ILE A 346
LEU A 360
ASP A 339
GLY A 340
ALA A 461
 None
 1.16A 6r2eF-3wfzA:
undetectable		 6r2eF-3wfzA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 3wfz LACTO-N-BIOSE
PHOSPHORYLASE
(Bifidobacterium
longum) 		5 / 12 ILE A 346
LEU A 360
ASP A 339
GLY A 340
ALA A 461
 None
 1.25A 6r2eH-3wfzA:
undetectable		 6r2eH-3wfzA:
16.91