SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wg6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		4 / 7 TYR A  60
VAL A 119
ILE A  82
LEU A  39
 NDP  A3001 (-4.7A)
None
None
None
 1.07A 1j96B-3wg6A:
34.7		 1j96B-3wg6A:
32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		3 / 3 ARG A 147
TYR A 104
LYS A 108
 None
 0.87A 1uujB-3wg6A:
undetectable		 1uujB-3wg6A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		5 / 11 GLY A  56
ALA A  57
ASP A  55
GLN A 183
ASN A 161
 None
None
NDP  A3001 (-3.9A)
NDP  A3001 (-3.8A)
NDP  A3001 (-3.1A)
 0.85A 2xtkA-3wg6A:
4.5		 2xtkA-3wg6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		4 / 7 TYR A 236
GLU A 275
LEU A 232
LYS A 231
 None
 1.42A 3k8mA-3wg6A:
4.5		 3k8mA-3wg6A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		4 / 7 TYR A  27
LEU A 114
LEU A  39
PHE A  21
 None
 1.09A 3nk2X-3wg6A:
undetectable		 3nk2X-3wg6A:
23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		5 / 12 TYR A  60
HIS A 125
ASN A 161
TYR A 211
PHE A 296
 NDP  A3001 (-4.7A)
NDP  A3001 (-4.2A)
NDP  A3001 (-3.1A)
NDP  A3001 (-3.3A)
NDP  A3001 (-3.7A)
 0.63A 3r43A-3wg6A:
34.3		 3r43A-3wg6A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		5 / 10 TYR A  60
HIS A 125
ASN A 161
TYR A 211
PHE A 296
 NDP  A3001 (-4.7A)
NDP  A3001 (-4.2A)
NDP  A3001 (-3.1A)
NDP  A3001 (-3.3A)
NDP  A3001 (-3.7A)
 0.59A 3r58A-3wg6A:
34.6		 3r58A-3wg6A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		5 / 12 TYR A  60
HIS A 125
ASN A 161
TYR A 211
PHE A 296
 NDP  A3001 (-4.7A)
NDP  A3001 (-4.2A)
NDP  A3001 (-3.1A)
NDP  A3001 (-3.3A)
NDP  A3001 (-3.7A)
 0.57A 3r6iA-3wg6A:
34.5		 3r6iA-3wg6A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		5 / 9 TYR A  60
HIS A 125
ASN A 161
TYR A 211
PHE A 296
 NDP  A3001 (-4.7A)
NDP  A3001 (-4.2A)
NDP  A3001 (-3.1A)
NDP  A3001 (-3.3A)
NDP  A3001 (-3.7A)
 0.61A 3r8gA-3wg6A:
34.6		 3r8gA-3wg6A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		5 / 12 TYR A  60
HIS A 125
ASN A 161
TYR A 211
PHE A 296
 NDP  A3001 (-4.7A)
NDP  A3001 (-4.2A)
NDP  A3001 (-3.1A)
NDP  A3001 (-3.3A)
NDP  A3001 (-3.7A)
 0.60A 3r94A-3wg6A:
34.5		 3r94A-3wg6A:
32.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		4 / 5 LEU A 171
TRP A 142
ILE A 157
ASN A  14
 None
 1.33A 4i00A-3wg6A:
undetectable		 4i00A-3wg6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		3 / 4 SER A 160
GLY A  22
GLU A  65
 NDP  A3001 (-3.0A)
NDP  A3001 (-3.3A)
None
 0.58A 4juoA-3wg6A:
undetectable
4juoC-3wg6A:
undetectable		 4juoA-3wg6A:
21.17
4juoC-3wg6A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		3 / 3 PRO A 224
LEU A 225
GLN A 283
 None
 0.49A 4pevB-3wg6A:
undetectable		 4pevB-3wg6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		4 / 6 PHE A  28
GLY A  61
TYR A  60
ALA A  57
 None
None
NDP  A3001 (-4.7A)
None
 1.25A 4yshB-3wg6A:
undetectable		 4yshB-3wg6A:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		5 / 9 TYR A  60
HIS A 125
ASN A 161
TYR A 211
PHE A 296
 NDP  A3001 (-4.7A)
NDP  A3001 (-4.2A)
NDP  A3001 (-3.1A)
NDP  A3001 (-3.3A)
NDP  A3001 (-3.7A)
 0.57A 4yvvA-3wg6A:
34.2		 4yvvA-3wg6A:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		4 / 7 LEU A 145
TYR A 104
PRO A 103
TYR A 122
 None
 1.06A 4z4fA-3wg6A:
undetectable		 4z4fA-3wg6A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		4 / 6 LEU A 145
TYR A 104
PRO A 103
TYR A 122
 None
 1.04A 4z4gA-3wg6A:
undetectable		 4z4gA-3wg6A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		3 / 3 GLY A 220
GLN A 295
LYS A 291
 None
 0.72A 5imsB-3wg6A:
undetectable		 5imsB-3wg6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		4 / 5 PHE A 296
SER A 297
GLN A 183
ASP A  84
 NDP  A3001 (-3.7A)
None
NDP  A3001 (-3.8A)
None
 1.26A 5kpcA-3wg6A:
undetectable		 5kpcA-3wg6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		4 / 7 LEU A 145
TYR A 104
PRO A 103
TYR A 122
 None
 1.05A 5t7bA-3wg6A:
undetectable		 5t7bA-3wg6A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3wg6 CONJUGATED
POLYKETONE REDUCTASE
C1
(Candida
parapsilosis) 		5 / 12 ASP A 120
LEU A 269
VAL A 268
ALA A  69
GLY A  67
 None
 1.14A 5uxdB-3wg6A:
undetectable		 5uxdB-3wg6A:
21.08