SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wgc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		4 / 8 ALA A 214
PHE A 215
ALA A 219
LEU A 209
 None
 0.85A 2bxmA-3wgcA:
undetectable		 2bxmA-3wgcA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		4 / 6 VAL A 100
SER A  94
LEU A 134
HIS A 166
 None
 1.25A 2f8dA-3wgcA:
undetectable		 2f8dA-3wgcA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 12 GLY A  45
ASP A  47
LEU A 208
LEU A 172
ASN A 174
 None
 1.15A 2zw9B-3wgcA:
undetectable		 2zw9B-3wgcA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		3 / 3 SER A  59
GLY A  60
THR A  61
 PLG  A 401 (-3.6A)
PLG  A 401 (-3.2A)
PLG  A 401 (-3.8A)
 0.19A 3k9wA-3wgcA:
undetectable		 3k9wA-3wgcA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		4 / 7 VAL A 193
VAL A  57
ILE A 216
MET A 230
 None
 1.34A 3ms9B-3wgcA:
undetectable		 3ms9B-3wgcA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 11 GLY A 169
LEU A 146
LEU A 186
LEU A 137
LEU A 167
 None
 1.39A 3ndvA-3wgcA:
undetectable
3ndvB-3wgcA:
undetectable		 3ndvA-3wgcA:
24.82
3ndvB-3wgcA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 11 LEU A 137
LEU A 167
GLY A 169
LEU A 146
LEU A 186
 None
 1.38A 3ndvA-3wgcA:
undetectable
3ndvB-3wgcA:
undetectable		 3ndvA-3wgcA:
24.82
3ndvB-3wgcA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 11 GLY A 169
LEU A 146
LEU A 186
LEU A 137
LEU A 167
 None
 1.39A 3ndvC-3wgcA:
undetectable
3ndvD-3wgcA:
undetectable		 3ndvC-3wgcA:
24.82
3ndvD-3wgcA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 11 LEU A 137
LEU A 167
GLY A 169
LEU A 146
LEU A 186
 None
 1.37A 3ndvC-3wgcA:
undetectable
3ndvD-3wgcA:
undetectable		 3ndvC-3wgcA:
24.82
3ndvD-3wgcA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		4 / 8 ASP A 168
ASP A   9
CYH A 196
GLU A 138
 PLG  A 401 (-2.9A)
None
PLG  A 401 ( 4.2A)
PLG  A 401 ( 4.0A)
 1.16A 4fewF-3wgcA:
undetectable		 4fewF-3wgcA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		4 / 8 ASP A 168
ASP A   9
CYH A 196
GLU A 138
 PLG  A 401 (-2.9A)
None
PLG  A 401 ( 4.2A)
PLG  A 401 ( 4.0A)
 1.13A 4gkhD-3wgcA:
undetectable		 4gkhD-3wgcA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		4 / 8 TYR A  44
GLY A  45
ALA A 188
GLY A  50
 None
 0.89A 5albL-3wgcA:
undetectable		 5albL-3wgcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_D_SAMD605_0
(GUANINE-N7
METHYLTRANSFERASE)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 10 GLY A  37
PRO A  36
ASP A  35
ALA A 233
GLN A 232
 None
 1.28A 5c8tD-3wgcA:
0.7		 5c8tD-3wgcA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		3 / 3 THR A  15
ASP A  16
ALA A  17
 None
 0.00A 5g5gB-3wgcA:
undetectable		 5g5gB-3wgcA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		4 / 6 VAL A  68
HIS A 166
LEU A 134
LEU A  80
 None
 1.19A 5hrqB-3wgcA:
undetectable
5hrqI-3wgcA:
undetectable
5hrqJ-3wgcA:
undetectable		 5hrqB-3wgcA:
6.36
5hrqI-3wgcA:
10.34
5hrqJ-3wgcA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		3 / 3 VAL A  11
SER A 307
MET A 299
 None
 0.90A 5ikqA-3wgcA:
undetectable		 5ikqA-3wgcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 12 VAL A 145
LEU A 201
ASP A   9
LEU A 251
SER A 179
 None
 0.99A 6b0lB-3wgcA:
undetectable		 6b0lB-3wgcA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		4 / 5 VAL A 248
LEU A  48
VAL A 210
LEU A  41
 None
 0.87A 6bqgA-3wgcA:
undetectable		 6bqgA-3wgcA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 12 VAL A  38
GLY A 227
VAL A 226
THR A  61
GLY A  60
 None
None
None
PLG  A 401 (-3.8A)
PLG  A 401 (-3.2A)
 1.17A 6brdC-3wgcA:
undetectable		 6brdC-3wgcA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		4 / 7 VAL A 187
GLY A 169
LEU A 208
GLY A  45
 None
 0.63A 6eu9D-3wgcA:
undetectable		 6eu9D-3wgcA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 10 VAL A 328
ALA A 331
LEU A   6
LEU A 265
LEU A 261
 None
 0.99A 6f5uA-3wgcA:
undetectable
6f5uB-3wgcA:
undetectable		 6f5uA-3wgcA:
11.82
6f5uB-3wgcA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		4 / 6 SER A  70
ARG A 220
ALA A 217
ALA A  54
 None
 1.10A 6ma6A-3wgcA:
undetectable		 6ma6A-3wgcA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 11 GLY A  60
SER A 194
ALA A 219
ALA A  67
HIS A 166
 PLG  A 401 (-3.2A)
None
None
None
None
 1.10A 6qgbA-3wgcA:
undetectable		 6qgbA-3wgcA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 3wgc L-ALLO-THREONINE
ALDOLASE
(Aeromonas
jandaei) 		5 / 11 GLY A  60
SER A 194
ALA A 219
ALA A  67
HIS A 166
 PLG  A 401 (-3.2A)
None
None
None
None
 1.09A 6qgbE-3wgcA:
undetectable		 6qgbE-3wgcA:
21.96