SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wgd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3wgd THIOREDOXIN
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		3 / 3 LEU A 139
TYR A 151
GLN A 152
 None
 0.63A 2wekA-3wgdA:
undetectable		 2wekA-3wgdA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3wgd THIOREDOXIN
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		3 / 3 LYS A 143
LEU A 141
ALA A  79
 None
 0.74A 4iizA-3wgdA:
undetectable		 4iizA-3wgdA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3wgd THIOREDOXIN
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 5 VAL A 127
VAL A 133
GLY A 132
PHE A  84
 None
 1.10A 5d4nA-3wgdA:
undetectable
5d4nC-3wgdA:
undetectable		 5d4nA-3wgdA:
17.39
5d4nC-3wgdA:
17.39