SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wgk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A 225
VAL A 131
GLY A 196
THR A 160
ILE A 162
 None
 0.86A 1c6zA-3wgkA:
undetectable		 1c6zA-3wgkA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A 225
VAL A 131
GLY A 196
THR A 160
ILE A 162
 None
 0.84A 1c6zB-3wgkA:
undetectable		 1c6zB-3wgkA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 SER A 103
ARG A  29
LEU A 190
ASP A  32
 None
None
GDP  A 400 (-4.9A)
None
 0.86A 1jg4A-3wgkA:
2.4		 1jg4A-3wgkA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 GLY A  23
THR A 102
VAL A  16
ILE A  41
 None
 0.74A 2a1mB-3wgkA:
undetectable		 2a1mB-3wgkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 7 THR A 294
LEU A 300
VAL A 203
ASP A 199
 None
 0.78A 2cppA-3wgkA:
undetectable		 2cppA-3wgkA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 10 THR A 160
ILE A 162
PHE A 100
THR A 311
ILE A 197
 None
 1.23A 2y7wB-3wgkA:
undetectable		 2y7wB-3wgkA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 6 LEU A 169
ILE A 172
PRO A 246
VAL A  38
 None
 1.11A 2ygoA-3wgkA:
undetectable		 2ygoA-3wgkA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A 400 (-3.5A)
GDP  A 400 (-3.4A)
None
None
None
 1.09A 3g8bA-3wgkA:
3.7		 3g8bA-3wgkA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 10 LEU A 127
VAL A 129
ILE A 201
LEU A  14
ILE A 197
 None
 1.03A 3jw3A-3wgkA:
2.5		 3jw3A-3wgkA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 5 GLY A 106
GLU A 139
GLY A 104
PRO A 135
 GDP  A 400 ( 4.7A)
GDP  A 400 (-2.6A)
GDP  A 400 ( 3.7A)
GDP  A 400 (-4.3A)
 1.10A 3onnA-3wgkA:
6.5		 3onnA-3wgkA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 9 LEU A 127
VAL A 189
ARG A 168
LEU A 259
VAL A 308
 None
 1.39A 3oxzA-3wgkA:
undetectable		 3oxzA-3wgkA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A 104
PRO A 115
GLY A 112
ASP A 187
PHE A 183
 GDP  A 400 ( 3.7A)
None
None
GDP  A 400 (-3.0A)
GDP  A 400 (-3.7A)
 1.49A 3r24A-3wgkA:
4.1		 3r24A-3wgkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 7 THR A 294
LEU A 300
VAL A 203
ASP A 199
 None
 0.81A 4cp4A-3wgkA:
undetectable		 4cp4A-3wgkA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A 110
GLY A 106
THR A 111
SER A 103
VAL A 101
 GDP  A 400 (-3.4A)
GDP  A 400 ( 4.7A)
None
None
None
 1.09A 4f84A-3wgkA:
3.5		 4f84A-3wgkA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 ASP A 199
VAL A 212
PHE A 100
LEU A  14
 None
 1.03A 4f8hA-3wgkA:
undetectable
4f8hB-3wgkA:
undetectable		 4f8hA-3wgkA:
21.07
4f8hB-3wgkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 ASP A 199
VAL A 212
PHE A 100
LEU A  14
 None
 1.01A 4f8hB-3wgkA:
undetectable
4f8hC-3wgkA:
undetectable		 4f8hB-3wgkA:
21.07
4f8hC-3wgkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 ASP A 199
VAL A 212
PHE A 100
LEU A  14
 None
 1.03A 4f8hC-3wgkA:
undetectable
4f8hD-3wgkA:
undetectable		 4f8hC-3wgkA:
21.07
4f8hD-3wgkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 ASP A 199
VAL A 212
PHE A 100
LEU A  14
 None
 1.03A 4f8hD-3wgkA:
undetectable
4f8hE-3wgkA:
undetectable		 4f8hD-3wgkA:
21.07
4f8hE-3wgkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 VAL A 212
PHE A 100
LEU A  14
ASP A 199
 None
 1.02A 4f8hA-3wgkA:
undetectable
4f8hE-3wgkA:
undetectable		 4f8hA-3wgkA:
21.07
4f8hE-3wgkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 ILE A  61
THR A 128
VAL A  99
ILE A  17
GLU A  39
 None
 1.16A 4i41A-3wgkA:
undetectable		 4i41A-3wgkA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 11 ILE A  77
ALA A  71
GLY A  70
GLY A  22
ASN A  24
 None
GDP  A 400 ( 4.9A)
None
GDP  A 400 (-3.4A)
None
 1.32A 4jdsC-3wgkA:
undetectable		 4jdsC-3wgkA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 ILE A  77
ALA A  71
GLY A  70
GLY A  22
ASN A  24
 None
GDP  A 400 ( 4.9A)
None
GDP  A 400 (-3.4A)
None
 1.28A 4jlgA-3wgkA:
undetectable		 4jlgA-3wgkA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 THR A 294
LEU A 300
VAL A 203
ASP A 199
 None
 0.84A 4l4aA-3wgkA:
undetectable		 4l4aA-3wgkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 MET A 224
ARG A 191
VAL A 280
VAL A 305
 None
 1.03A 4mk4A-3wgkA:
4.1		 4mk4A-3wgkA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 11 GLY A 225
VAL A 131
GLY A 196
THR A 160
ILE A 162
 None
 0.90A 4njvB-3wgkA:
undetectable		 4njvB-3wgkA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 11 GLY A 225
VAL A 131
GLY A 196
THR A 160
ILE A 162
 None
 0.90A 4njvC-3wgkA:
undetectable		 4njvC-3wgkA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 ILE A  59
ILE A  89
ALA A  81
VAL A 117
VAL A 116
 None
 1.14A 4nkvA-3wgkA:
undetectable		 4nkvA-3wgkA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 ILE A  59
ILE A  89
ALA A  81
VAL A 117
VAL A 116
 None
 1.16A 4nkvC-3wgkA:
undetectable		 4nkvC-3wgkA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 6 SER A 245
GLY A 196
ARG A 191
GLY A 193
 None
 0.73A 5cdnA-3wgkA:
undetectable
5cdnB-3wgkA:
4.1		 5cdnA-3wgkA:
21.13
5cdnB-3wgkA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
GDP  A 400 (-3.3A)
GDP  A 400 (-3.5A)
None
 0.96A 5d4uA-3wgkA:
3.5		 5d4uA-3wgkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
GDP  A 400 (-3.3A)
GDP  A 400 (-3.5A)
None
 0.97A 5d4uB-3wgkA:
3.6		 5d4uB-3wgkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
GDP  A 400 (-3.3A)
GDP  A 400 (-3.5A)
None
 0.99A 5d4uC-3wgkA:
undetectable		 5d4uC-3wgkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A  78
ILE A  61
THR A 109
GLY A  20
GLY A 150
 None
None
GDP  A 400 (-3.3A)
GDP  A 400 (-3.5A)
None
 0.92A 5d4uD-3wgkA:
undetectable		 5d4uD-3wgkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 5 PRO A 115
ALA A 118
ALA A 157
LEU A 161
 None
 0.75A 5jncD-3wgkA:
undetectable		 5jncD-3wgkA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 9 ALA A 113
VAL A  19
ILE A  41
ILE A  93
ALA A  82
 None
 1.01A 5nunA-3wgkA:
undetectable		 5nunA-3wgkA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A 104
PRO A 115
GLY A 112
ASP A 187
PHE A 183
 GDP  A 400 ( 3.7A)
None
None
GDP  A 400 (-3.0A)
GDP  A 400 (-3.7A)
 1.36A 5yn6A-3wgkA:
undetectable		 5yn6A-3wgkA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 3wgk CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 9 SER A 103
VAL A 117
ALA A 118
VAL A  19
GLY A 130
 None
 1.17A 6bklA-3wgkA:
undetectable
6bklB-3wgkA:
undetectable
6bklC-3wgkA:
undetectable
6bklD-3wgkA:
undetectable		 6bklA-3wgkA:
8.14
6bklB-3wgkA:
8.14
6bklC-3wgkA:
8.14
6bklD-3wgkA:
8.14