SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wgp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A 404
HIS A 305
GLU A 220
HIS A 397
LEU A 309
 None
ED9  A 501 (-3.9A)
None
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
 1.34A 1d4fB-3wgpA:
undetectable		 1d4fB-3wgpA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A 233
SER A 237
SER A 278
CYH A 288
LEU A 393
 ED9  A 501 ( 4.3A)
ED9  A 501 (-2.7A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
None
 1.27A 1db1A-3wgpA:
42.0		 1db1A-3wgpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		12 / 12 TYR A 143
LEU A 230
LEU A 233
VAL A 234
SER A 237
SER A 275
SER A 278
CYH A 288
VAL A 300
HIS A 305
LEU A 309
HIS A 397
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.6A)
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 0.19A 1db1A-3wgpA:
42.0		 1db1A-3wgpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		6 / 6 LEU A 227
ILE A 271
ARG A 274
TRP A 286
TYR A 295
VAL A 418
 None
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.5A)
None
None
 0.14A 1db1A-3wgpA:
42.0		 1db1A-3wgpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 9 THR A 362
LEU A 332
VAL A 331
ILE A 248
ILE A 134
 None
 1.31A 1gebA-3wgpA:
undetectable		 1gebA-3wgpA:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		12 / 12 TYR A 143
LEU A 230
LEU A 233
VAL A 234
SER A 237
SER A 275
SER A 278
CYH A 288
VAL A 300
HIS A 305
LEU A 313
HIS A 397
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.6A)
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
None
ED9  A 501 (-3.9A)
 0.17A 1ie9A-3wgpA:
42.6		 1ie9A-3wgpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IE9_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		4 / 4 LEU A 227
ILE A 271
ARG A 274
TRP A 286
 None
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.5A)
 0.30A 1ie9A-3wgpA:
42.6		 1ie9A-3wgpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 10 GLY A 304
ASP A 299
VAL A 297
GLY A 164
ILE A 310
 None
 0.94A 1muiA-3wgpA:
undetectable		 1muiA-3wgpA:
17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 233
SER A 237
SER A 278
TRP A 286
CYH A 288
LEU A 393
 ED9  A 501 ( 4.3A)
ED9  A 501 (-2.7A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.5A)
ED9  A 501 (-3.4A)
None
 1.38A 1rk3A-3wgpA:
38.8		 1rk3A-3wgpA:
89.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		12 / 12 TYR A 143
LEU A 233
VAL A 234
SER A 237
SER A 275
SER A 278
TRP A 286
CYH A 288
VAL A 300
HIS A 305
LEU A 309
HIS A 397
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.5A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 0.21A 1rk3A-3wgpA:
38.8		 1rk3A-3wgpA:
89.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		4 / 4 LEU A 227
ILE A 271
ARG A 274
TYR A 401
 None
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
None
 0.37A 1rk3A-3wgpA:
38.8		 1rk3A-3wgpA:
89.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		12 / 12 LEU A 227
LEU A 233
VAL A 234
ILE A 271
SER A 275
SER A 278
TRP A 286
CYH A 288
TYR A 295
VAL A 300
LEU A 309
LEU A 313
 None
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.5A)
ED9  A 501 (-3.4A)
None
ED9  A 501 (-4.5A)
ED9  A 501 (-4.9A)
None
 0.16A 1s19A-3wgpA:
42.0		 1s19A-3wgpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 5 TYR A 143
SER A 237
ARG A 274
HIS A 305
HIS A 397
 ED9  A 501 (-3.7A)
ED9  A 501 (-2.7A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
ED9  A 501 (-3.9A)
 0.13A 1s19A-3wgpA:
42.0		 1s19A-3wgpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 12 PHE A 150
SER A 237
SER A 278
CYH A 288
LEU A 393
 None
ED9  A 501 (-2.7A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
None
 1.28A 2hc4A-3wgpA:
37.7		 2hc4A-3wgpA:
64.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		7 / 12 PHE A 153
LEU A 233
VAL A 234
SER A 237
HIS A 305
LEU A 309
HIS A 397
 None
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 1.43A 2hc4A-3wgpA:
37.7		 2hc4A-3wgpA:
64.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		12 / 12 TYR A 143
PHE A 150
LEU A 233
VAL A 234
SER A 237
SER A 278
CYH A 288
VAL A 300
HIS A 305
LEU A 309
HIS A 397
LEU A 404
 ED9  A 501 (-3.7A)
None
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
None
 0.28A 2hc4A-3wgpA:
37.7		 2hc4A-3wgpA:
64.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		7 / 7 LEU A 227
LEU A 230
ILE A 271
ARG A 274
SER A 275
TRP A 286
TYR A 401
 None
ED9  A 501 ( 4.6A)
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
ED9  A 501 (-3.5A)
None
 0.39A 2hc4A-3wgpA:
37.7		 2hc4A-3wgpA:
64.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		4 / 7 LEU A 414
ILE A 271
ARG A 274
SER A 275
 None
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
 1.22A 2hc4A-3wgpA:
37.7		 2hc4A-3wgpA:
64.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		3 / 3 ASP A 149
THR A 415
PRO A 416
 None
 0.67A 2pynB-3wgpA:
undetectable		 2pynB-3wgpA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		3 / 3 ASP A 149
THR A 415
PRO A 416
 None
 0.67A 2q64B-3wgpA:
undetectable		 2q64B-3wgpA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		3 / 3 ASP A 149
THR A 415
PRO A 416
 None
 0.69A 2qakB-3wgpA:
undetectable		 2qakB-3wgpA:
17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		12 / 12 TYR A 143
LEU A 233
VAL A 234
SER A 237
SER A 275
SER A 278
CYH A 288
VAL A 300
HIS A 305
LEU A 309
HIS A 397
LEU A 404
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
None
 0.25A 2zlcA-3wgpA:
38.7		 2zlcA-3wgpA:
90.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 5 LEU A 227
ILE A 271
ARG A 274
TRP A 286
TYR A 401
 None
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.5A)
None
 0.36A 2zlcA-3wgpA:
38.7		 2zlcA-3wgpA:
90.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A 230
VAL A 234
SER A 237
VAL A 300
LEU A 313
 ED9  A 501 ( 4.6A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-4.5A)
None
 1.16A 3m7rA-3wgpA:
42.6		 3m7rA-3wgpA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		10 / 12 TYR A 143
LEU A 230
LEU A 233
VAL A 234
SER A 275
SER A 278
CYH A 288
VAL A 300
LEU A 309
HIS A 397
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.6A)
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 0.20A 3m7rA-3wgpA:
42.6		 3m7rA-3wgpA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		10 / 12 TYR A 143
LEU A 230
VAL A 234
SER A 237
SER A 275
SER A 278
CYH A 288
VAL A 300
LEU A 309
HIS A 397
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.6A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 0.56A 3m7rA-3wgpA:
42.6		 3m7rA-3wgpA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3M7R_A_VDXA425_2
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		9 / 9 PHE A 150
LEU A 227
ILE A 271
ARG A 274
TRP A 286
TYR A 295
LEU A 313
TYR A 401
VAL A 418
 None
None
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.5A)
None
None
None
None
 0.17A 3m7rA-3wgpA:
42.6		 3m7rA-3wgpA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		3 / 3 ASP A 149
THR A 415
PRO A 416
 None
 0.66A 3tkgD-3wgpA:
undetectable		 3tkgD-3wgpA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 9 LEU A 387
LEU A 333
ILE A 248
ILE A 355
GLN A 356
 None
 1.11A 3tmzA-3wgpA:
1.2		 3tmzA-3wgpA:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 233
SER A 237
SER A 278
TRP A 286
CYH A 288
LEU A 393
 ED9  A 501 ( 4.3A)
ED9  A 501 (-2.7A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.5A)
ED9  A 501 (-3.4A)
None
 1.39A 3vt3A-3wgpA:
38.3		 3vt3A-3wgpA:
90.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		12 / 12 TYR A 143
LEU A 233
VAL A 234
SER A 237
SER A 275
SER A 278
TRP A 286
CYH A 288
VAL A 300
HIS A 305
LEU A 309
HIS A 397
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.5A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 0.21A 3vt3A-3wgpA:
38.3		 3vt3A-3wgpA:
90.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		11 / 12 TYR A 143
LEU A 233
VAL A 234
SER A 237
ARG A 274
SER A 275
SER A 278
VAL A 300
HIS A 305
LEU A 309
HIS A 397
 ED9  A 501 (-3.7A)
ED9  A 501 ( 4.3A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 0.21A 3vt7A-3wgpA:
36.6		 3vt7A-3wgpA:
90.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		11 / 12 TYR A 143
TYR A 147
VAL A 234
SER A 237
ARG A 274
SER A 275
SER A 278
VAL A 300
HIS A 305
LEU A 309
HIS A 397
 ED9  A 501 (-3.7A)
None
None
ED9  A 501 (-2.7A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-4.9A)
ED9  A 501 (-3.9A)
 0.60A 3vt7A-3wgpA:
36.6		 3vt7A-3wgpA:
90.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		4 / 4 LEU A 227
ILE A 271
TYR A 295
TYR A 401
 None
ED9  A 501 (-4.5A)
None
None
 0.39A 3vt7A-3wgpA:
36.6		 3vt7A-3wgpA:
90.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A 351
ILE A 355
ARG A 358
 None
 0.64A 4mk4B-3wgpA:
undetectable		 4mk4B-3wgpA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A 304
ASP A 299
VAL A 297
GLY A 164
ILE A 310
 None
 0.99A 4njvA-3wgpA:
undetectable		 4njvA-3wgpA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 11 GLY A 304
ASP A 299
VAL A 297
GLY A 164
ILE A 310
 None
 1.03A 4njvB-3wgpA:
undetectable		 4njvB-3wgpA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A 304
ASP A 299
VAL A 297
GLY A 164
ILE A 310
 None
 0.97A 4njvD-3wgpA:
undetectable		 4njvD-3wgpA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 335
TYR A 380
SER A 360
LEU A 363
LEU A 325
 None
 1.43A 4qztC-3wgpA:
undetectable		 4qztC-3wgpA:
16.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		12 / 12 TYR A 143
VAL A 234
SER A 237
ILE A 271
ARG A 274
SER A 275
SER A 278
TRP A 286
CYH A 288
VAL A 300
HIS A 305
HIS A 397
 ED9  A 501 (-3.7A)
None
ED9  A 501 (-2.7A)
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.5A)
ED9  A 501 (-3.4A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-3.9A)
 0.26A 4rujA-3wgpA:
37.4		 4rujA-3wgpA:
64.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		4 / 8 LEU A 254
ILE A 248
ARG A 358
LEU A 359
 None
 0.81A 4zvcA-3wgpA:
2.1
4zvcB-3wgpA:
undetectable		 4zvcA-3wgpA:
20.99
4zvcB-3wgpA:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		7 / 12 PHE A 153
LEU A 233
SER A 237
ILE A 271
ARG A 274
HIS A 305
HIS A 397
 None
ED9  A 501 ( 4.3A)
ED9  A 501 (-2.7A)
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
ED9  A 501 (-3.9A)
 1.37A 5h1eA-3wgpA:
37.4		 5h1eA-3wgpA:
90.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		12 / 12 TYR A 143
PHE A 150
LEU A 233
SER A 237
ILE A 271
ARG A 274
SER A 275
SER A 278
TRP A 286
VAL A 300
HIS A 305
HIS A 397
 ED9  A 501 (-3.7A)
None
ED9  A 501 ( 4.3A)
ED9  A 501 (-2.7A)
ED9  A 501 (-4.5A)
ED9  A 501 (-2.9A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.5A)
ED9  A 501 (-4.5A)
ED9  A 501 (-3.9A)
ED9  A 501 (-3.9A)
 0.32A 5h1eA-3wgpA:
37.4		 5h1eA-3wgpA:
90.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 3wgp VITAMIN D3 RECEPTOR
(Homo
sapiens) 		7 / 12 TYR A 143
PHE A 150
LEU A 233
SER A 275
SER A 278
TRP A 286
HIS A 305
 ED9  A 501 (-3.7A)
None
ED9  A 501 ( 4.3A)
ED9  A 501 (-3.9A)
ED9  A 501 (-2.7A)
ED9  A 501 (-3.5A)
ED9  A 501 (-3.9A)
 1.19A 5h1eA-3wgpA:
37.4		 5h1eA-3wgpA:
90.51