SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wh7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 12 LEU A  71
LEU A  68
TYR A  76
LEU A 402
ILE A 429
 None
 0.77A 1s9pA-3wh7A:
undetectable		 1s9pA-3wh7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 12 LEU A  71
LEU A  68
TYR A  76
LEU A 402
ILE A 429
 None
 0.81A 1s9pD-3wh7A:
undetectable		 1s9pD-3wh7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 5 PHE A 243
LEU A 187
MET A 264
LEU A 252
 None
 0.99A 1skxA-3wh7A:
undetectable		 1skxA-3wh7A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 6 HIS A 121
ASP A 403
TYR A 415
TRP A 122
 FCB  A 501 (-4.0A)
None
FCB  A 501 ( 3.7A)
None
 1.47A 2dysA-3wh7A:
undetectable
2dysC-3wh7A:
undetectable		 2dysA-3wh7A:
21.89
2dysC-3wh7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 6 HIS A 121
ASP A 403
TYR A 415
TRP A 122
 FCB  A 501 (-4.0A)
None
FCB  A 501 ( 3.7A)
None
 1.47A 2dysN-3wh7A:
undetectable
2dysP-3wh7A:
undetectable		 2dysN-3wh7A:
21.89
2dysP-3wh7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 7 HIS A 121
ASP A 403
TYR A 415
TRP A 122
 FCB  A 501 (-4.0A)
None
FCB  A 501 ( 3.7A)
None
 1.49A 2eikA-3wh7A:
undetectable
2eikC-3wh7A:
undetectable		 2eikA-3wh7A:
21.89
2eikC-3wh7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 6 HIS A 121
ASP A 403
TYR A 415
TRP A 122
 FCB  A 501 (-4.0A)
None
FCB  A 501 ( 3.7A)
None
 1.42A 2eimA-3wh7A:
undetectable
2eimC-3wh7A:
undetectable		 2eimA-3wh7A:
21.89
2eimC-3wh7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 6 HIS A 121
ASP A 403
TYR A 415
TRP A 122
 FCB  A 501 (-4.0A)
None
FCB  A 501 ( 3.7A)
None
 1.48A 2einA-3wh7A:
undetectable
2einC-3wh7A:
undetectable		 2einA-3wh7A:
21.89
2einC-3wh7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 7 ARG A 241
ALA A 300
PRO A 309
ALA A 311
 None
 1.00A 2ejfA-3wh7A:
undetectable		 2ejfA-3wh7A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 12 ASP A  47
GLY A  48
PHE A 405
VAL A  25
ASP A  52
 None
 1.02A 2fqyA-3wh7A:
undetectable		 2fqyA-3wh7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 12 ASP A  47
PHE A 405
GLY A  51
VAL A  25
ASP A  52
 None
 1.50A 2fqyA-3wh7A:
undetectable		 2fqyA-3wh7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 6 HIS A 379
PHE A 376
ARG A 325
GLY A 354
 None
 1.24A 2i30A-3wh7A:
undetectable		 2i30A-3wh7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 11 ASN A 165
GLU A 166
TYR A 295
GLU A 352
TRP A 399
 FCB  A 501 (-2.9A)
FCB  A 501 (-2.5A)
FCB  A 501 (-4.6A)
FCB  A 501 (-2.7A)
FCB  A 501 (-3.6A)
 0.82A 2v3dB-3wh7A:
15.4		 2v3dB-3wh7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 8 TYR A 260
LEU A 280
ALA A 284
HIS A 195
 None
 1.04A 2wekA-3wh7A:
undetectable		 2wekA-3wh7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 8 VAL A 179
ARG A 189
GLY A 190
ALA A 193
 None
 0.95A 2xh9A-3wh7A:
undetectable		 2xh9A-3wh7A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 10 ARG A  26
GLY A  23
ALA A  54
TYR A  19
HIS A  40
 None
 1.18A 3boyA-3wh7A:
undetectable
3boyC-3wh7A:
undetectable		 3boyA-3wh7A:
15.55
3boyC-3wh7A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 10 TYR A  19
HIS A  40
ARG A  26
GLY A  23
ALA A  54
 None
 1.18A 3boyA-3wh7A:
undetectable
3boyB-3wh7A:
undetectable		 3boyA-3wh7A:
15.55
3boyB-3wh7A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 10 TYR A  19
HIS A  40
ARG A  26
GLY A  23
ALA A  54
 None
 1.17A 3boyB-3wh7A:
undetectable
3boyC-3wh7A:
undetectable		 3boyB-3wh7A:
15.55
3boyC-3wh7A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		3 / 3 TYR A  58
ASP A  56
ASP A  52
 None
 0.89A 3ou7B-3wh7A:
undetectable		 3ou7B-3wh7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 12 GLN A 282
GLY A 200
LEU A 198
ALA A 140
ASN A 196
 None
 1.26A 3sxjA-3wh7A:
undetectable		 3sxjA-3wh7A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 12 GLN A 282
GLY A 200
GLY A 202
ALA A 140
ASN A 196
 None
 1.26A 3sxjB-3wh7A:
undetectable		 3sxjB-3wh7A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 12 GLN A 282
GLY A 200
LEU A 198
ALA A 140
ASN A 196
 None
 1.25A 3sxjB-3wh7A:
undetectable		 3sxjB-3wh7A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 5 SER A 432
GLY A 433
TRP A 435
ASP A 438
 None
 1.08A 3w9tB-3wh7A:
undetectable		 3w9tB-3wh7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 5 SER A 432
GLY A 433
TRP A 435
ASP A 438
 None
 1.08A 3w9tC-3wh7A:
undetectable		 3w9tC-3wh7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 5 SER A 432
GLY A 433
TRP A 435
ASP A 438
 None
 1.07A 3w9tD-3wh7A:
undetectable		 3w9tD-3wh7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 7 GLY A  23
ASP A  52
GLY A  51
HIS A  40
 None
 0.80A 4c5nA-3wh7A:
undetectable		 4c5nA-3wh7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 8 GLY A  23
ASP A  52
GLY A  51
HIS A  40
 None
 0.78A 4c5nC-3wh7A:
2.7		 4c5nC-3wh7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		3 / 3 ASP A 123
TRP A 399
SER A  79
 None
FCB  A 501 (-3.6A)
None
 1.00A 4lrhB-3wh7A:
undetectable		 4lrhB-3wh7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		3 / 3 ASP A 123
TRP A 399
SER A  79
 None
FCB  A 501 (-3.6A)
None
 1.09A 4lrhF-3wh7A:
undetectable		 4lrhF-3wh7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 12 ALA A 138
SER A 136
GLY A 133
GLY A  89
GLU A 145
 None
 1.16A 4r29C-3wh7A:
undetectable		 4r29C-3wh7A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		3 / 3 ASN A 165
PHE A 397
TYR A  76
 FCB  A 501 (-2.9A)
None
None
 0.68A 4u15A-3wh7A:
undetectable		 4u15A-3wh7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 4 PHE A 376
ASP A 369
GLY A 354
SER A 432
 None
 1.31A 4xp9C-3wh7A:
0.0		 4xp9C-3wh7A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 12 GLY A 178
LEU A 308
GLY A 269
LEU A 191
THR A 185
 None
 1.14A 4ze1A-3wh7A:
undetectable		 4ze1A-3wh7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 12 GLY A 178
LEU A 308
GLY A 269
LEU A 191
THR A 185
 None
 1.12A 4ze2A-3wh7A:
undetectable		 4ze2A-3wh7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 10 ALA A 204
ARG A 209
ALA A 147
VAL A 151
LEU A 287
 None
 1.41A 5eb5B-3wh7A:
undetectable		 5eb5B-3wh7A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 12 LEU A 224
LEU A 222
ASN A 223
SER A 194
LEU A 198
 None
 1.19A 5mwyA-3wh7A:
undetectable		 5mwyA-3wh7A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 12 LEU A 252
LEU A 255
ALA A 256
ILE A 335
LEU A 348
 None
None
None
NHE  A 502 (-4.4A)
None
 0.91A 5toaA-3wh7A:
undetectable		 5toaA-3wh7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 10 MET A 172
GLY A 178
GLY A 183
LEU A 191
THR A 185
 None
 0.99A 5vm8B-3wh7A:
undetectable		 5vm8B-3wh7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		4 / 5 ILE A 417
PHE A 376
TYR A 396
THR A 351
 None
 1.25A 5z84N-3wh7A:
undetectable
5z84W-3wh7A:
undetectable		 5z84N-3wh7A:
21.89
5z84W-3wh7A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 10 GLY A 259
ARG A 258
ALA A 256
LEU A 252
PHE A 397
 None
 1.33A 5zjiA-3wh7A:
undetectable
5zjiJ-3wh7A:
undetectable		 5zjiA-3wh7A:
10.79
5zjiJ-3wh7A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3wh7 BETA-GLUCOSIDASE
(metagenomes) 		5 / 12 ASP A 279
ALA A 285
GLY A 200
ARG A 137
SER A 136
 None
 1.26A 6clxA-3wh7A:
undetectable		 6clxA-3wh7A:
22.73