SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3whl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 11 LEU A 220
ALA A 236
ALA A 232
MET A 231
LEU A 186
 LEU  A 220 ( 0.5A)
ALA  A 236 ( 0.0A)
ALA  A 232 ( 0.0A)
MET  A 231 ( 0.0A)
LEU  A 186 (-0.6A)
 1.11A 1iiuA-3whlA:
undetectable		 1iiuA-3whlA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 12 LEU A 220
ALA A 236
ALA A 232
MET A 231
LEU A 186
 LEU  A 220 ( 0.5A)
ALA  A 236 ( 0.0A)
ALA  A 232 ( 0.0A)
MET  A 231 ( 0.0A)
LEU  A 186 (-0.6A)
 1.13A 1kt5A-3whlA:
undetectable		 1kt5A-3whlA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		4 / 7 LEU A 193
ILE A 197
ALA A 232
ILE A 280
 LEU  A 193 ( 0.6A)
ILE  A 197 ( 0.7A)
ALA  A 232 ( 0.0A)
ILE  A 280 ( 0.7A)
 0.95A 1oniB-3whlA:
undetectable
1oniC-3whlA:
undetectable		 1oniB-3whlA:
20.37
1oniC-3whlA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 10 LEU A 220
ALA A 236
ALA A 232
MET A 231
LEU A 186
 LEU  A 220 ( 0.5A)
ALA  A 236 ( 0.0A)
ALA  A 232 ( 0.0A)
MET  A 231 ( 0.0A)
LEU  A 186 (-0.6A)
 1.16A 1rlbE-3whlA:
undetectable		 1rlbE-3whlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 11 LEU A 220
ALA A 236
ALA A 232
MET A 231
LEU A 186
 LEU  A 220 ( 0.5A)
ALA  A 236 ( 0.0A)
ALA  A 232 ( 0.0A)
MET  A 231 ( 0.0A)
LEU  A 186 (-0.6A)
 1.09A 1rlbF-3whlA:
undetectable		 1rlbF-3whlA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 10 ILE A 277
ALA A 234
LEU A 190
LEU A 220
ILE A 324
 ILE  A 277 ( 0.7A)
ALA  A 234 ( 0.0A)
LEU  A 190 ( 0.6A)
LEU  A 220 ( 0.5A)
ILE  A 324 ( 0.7A)
 1.13A 2w9sD-3whlA:
undetectable		 2w9sD-3whlA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 10 ILE A 277
ALA A 234
LEU A 190
LEU A 220
ILE A 324
 ILE  A 277 ( 0.7A)
ALA  A 234 ( 0.0A)
LEU  A 190 ( 0.6A)
LEU  A 220 ( 0.5A)
ILE  A 324 ( 0.7A)
 1.13A 2w9sF-3whlA:
undetectable		 2w9sF-3whlA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 12 ILE A 278
LEU A 262
SER A 249
ILE A 286
ILE A 280
 ILE  A 278 ( 0.7A)
LEU  A 262 ( 0.6A)
SER  A 249 ( 0.0A)
ILE  A 286 ( 0.7A)
ILE  A 280 ( 0.7A)
 0.97A 3drcA-3whlA:
undetectable		 3drcA-3whlA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 12 HIS A 264
VAL A 246
ILE A 280
LEU A 308
THR A 304
 HIS  A 264 ( 1.0A)
VAL  A 246 ( 0.6A)
ILE  A 280 ( 0.7A)
LEU  A 308 ( 0.6A)
THR  A 304 ( 0.8A)
 0.95A 3fw3A-3whlA:
undetectable		 3fw3A-3whlA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 11 THR A 276
ALA A 270
LEU A 266
PHE A 267
ILE A 197
 THR  A 276 ( 0.8A)
ALA  A 270 ( 0.0A)
LEU  A 266 ( 0.6A)
PHE  A 267 ( 1.3A)
ILE  A 197 ( 0.7A)
 1.33A 4claA-3whlA:
undetectable		 4claA-3whlA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		4 / 7 PHE A 315
GLY A 217
ILE A 278
PHE A 267
 PHE  A 315 ( 1.3A)
GLY  A 217 ( 0.0A)
ILE  A 278 ( 0.7A)
PHE  A 267 ( 1.3A)
 0.81A 4ejjA-3whlA:
undetectable		 4ejjA-3whlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 11 ALA A 358
ALA A 380
GLY A 184
GLY A 185
ASP A 353
 ALA  A 358 ( 0.0A)
ALA  A 380 ( 0.0A)
GLY  A 184 (-0.0A)
GLY  A 185 ( 0.0A)
ASP  A 353 ( 0.6A)
 1.04A 4qvlK-3whlA:
undetectable
4qvlL-3whlA:
undetectable		 4qvlK-3whlA:
20.59
4qvlL-3whlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 11 ALA A 358
ALA A 380
GLY A 184
GLY A 185
ASP A 353
 ALA  A 358 ( 0.0A)
ALA  A 380 ( 0.0A)
GLY  A 184 (-0.0A)
GLY  A 185 ( 0.0A)
ASP  A 353 ( 0.6A)
 1.04A 4qvlY-3whlA:
undetectable
4qvlZ-3whlA:
undetectable		 4qvlY-3whlA:
20.59
4qvlZ-3whlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 9 ALA A 358
ALA A 380
GLY A 184
GLY A 185
ASP A 353
 ALA  A 358 ( 0.0A)
ALA  A 380 ( 0.0A)
GLY  A 184 (-0.0A)
GLY  A 185 ( 0.0A)
ASP  A 353 ( 0.6A)
 1.02A 4qvmK-3whlA:
undetectable
4qvmL-3whlA:
undetectable		 4qvmK-3whlA:
20.59
4qvmL-3whlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 10 ALA A 358
ALA A 380
GLY A 184
GLY A 185
ASP A 353
 ALA  A 358 ( 0.0A)
ALA  A 380 ( 0.0A)
GLY  A 184 (-0.0A)
GLY  A 185 ( 0.0A)
ASP  A 353 ( 0.6A)
 1.02A 4qvmY-3whlA:
undetectable
4qvmZ-3whlA:
undetectable		 4qvmY-3whlA:
20.59
4qvmZ-3whlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 11 ALA A 358
ALA A 380
GLY A 184
GLY A 185
ASP A 353
 ALA  A 358 ( 0.0A)
ALA  A 380 ( 0.0A)
GLY  A 184 (-0.0A)
GLY  A 185 ( 0.0A)
ASP  A 353 ( 0.6A)
 1.02A 4qvwK-3whlA:
undetectable
4qvwL-3whlA:
undetectable		 4qvwK-3whlA:
20.59
4qvwL-3whlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 11 ALA A 358
ALA A 380
GLY A 184
GLY A 185
ASP A 353
 ALA  A 358 ( 0.0A)
ALA  A 380 ( 0.0A)
GLY  A 184 (-0.0A)
GLY  A 185 ( 0.0A)
ASP  A 353 ( 0.6A)
 1.02A 4qvwY-3whlA:
undetectable
4qvwZ-3whlA:
undetectable		 4qvwY-3whlA:
20.59
4qvwZ-3whlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 10 ALA A 358
ALA A 380
GLY A 184
GLY A 185
ASP A 353
 ALA  A 358 ( 0.0A)
ALA  A 380 ( 0.0A)
GLY  A 184 (-0.0A)
GLY  A 185 ( 0.0A)
ASP  A 353 ( 0.6A)
 1.00A 4qw3K-3whlA:
undetectable
4qw3L-3whlA:
undetectable		 4qw3K-3whlA:
20.59
4qw3L-3whlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 10 ALA A 358
ALA A 380
GLY A 184
GLY A 185
ASP A 353
 ALA  A 358 ( 0.0A)
ALA  A 380 ( 0.0A)
GLY  A 184 (-0.0A)
GLY  A 185 ( 0.0A)
ASP  A 353 ( 0.6A)
 1.00A 4qw3Y-3whlA:
undetectable
4qw3Z-3whlA:
undetectable		 4qw3Y-3whlA:
20.59
4qw3Z-3whlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 12 LEU A 309
THR A 327
ALA A 325
VAL A 323
ILE A 280
 LEU  A 309 ( 0.6A)
THR  A 327 ( 0.8A)
ALA  A 325 ( 0.0A)
VAL  A 323 ( 0.6A)
ILE  A 280 ( 0.7A)
 1.09A 4x1kD-3whlA:
undetectable		 4x1kD-3whlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 12 LEU A 309
LEU A 337
ALA A 325
VAL A 323
ILE A 283
 LEU  A 309 ( 0.6A)
LEU  A 337 ( 0.6A)
ALA  A 325 ( 0.0A)
VAL  A 323 ( 0.6A)
ILE  A 283 ( 0.7A)
 1.17A 4x1yB-3whlA:
undetectable		 4x1yB-3whlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 12 LEU A 309
LEU A 337
THR A 327
ALA A 325
VAL A 323
 LEU  A 309 ( 0.6A)
LEU  A 337 ( 0.6A)
THR  A 327 ( 0.8A)
ALA  A 325 ( 0.0A)
VAL  A 323 ( 0.6A)
 1.16A 4x1yB-3whlA:
undetectable		 4x1yB-3whlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 12 LEU A 309
LEU A 337
THR A 327
ALA A 325
VAL A 323
 LEU  A 309 ( 0.6A)
LEU  A 337 ( 0.6A)
THR  A 327 ( 0.8A)
ALA  A 325 ( 0.0A)
VAL  A 323 ( 0.6A)
 1.04A 4x1yD-3whlA:
undetectable		 4x1yD-3whlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 11 LEU A 309
LEU A 337
THR A 327
ALA A 325
VAL A 323
 LEU  A 309 ( 0.6A)
LEU  A 337 ( 0.6A)
THR  A 327 ( 0.8A)
ALA  A 325 ( 0.0A)
VAL  A 323 ( 0.6A)
 0.93A 4x20D-3whlA:
undetectable		 4x20D-3whlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 11 LEU A 309
THR A 327
ALA A 325
VAL A 323
ILE A 280
 LEU  A 309 ( 0.6A)
THR  A 327 ( 0.8A)
ALA  A 325 ( 0.0A)
VAL  A 323 ( 0.6A)
ILE  A 280 ( 0.7A)
 1.09A 4x20D-3whlA:
undetectable		 4x20D-3whlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 11 ALA A 358
ALA A 380
GLY A 184
GLY A 185
ASP A 353
 ALA  A 358 ( 0.0A)
ALA  A 380 ( 0.0A)
GLY  A 184 (-0.0A)
GLY  A 185 ( 0.0A)
ASP  A 353 ( 0.6A)
 1.03A 5bxnK-3whlA:
undetectable
5bxnL-3whlA:
undetectable		 5bxnK-3whlA:
20.59
5bxnL-3whlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 9 ALA A 358
ALA A 380
GLY A 184
GLY A 185
ASP A 353
 ALA  A 358 ( 0.0A)
ALA  A 380 ( 0.0A)
GLY  A 184 (-0.0A)
GLY  A 185 ( 0.0A)
ASP  A 353 ( 0.6A)
 1.04A 5d0xK-3whlA:
undetectable
5d0xL-3whlA:
undetectable		 5d0xK-3whlA:
20.59
5d0xL-3whlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		5 / 9 ALA A 358
ALA A 380
GLY A 184
GLY A 185
ASP A 353
 ALA  A 358 ( 0.0A)
ALA  A 380 ( 0.0A)
GLY  A 184 (-0.0A)
GLY  A 185 ( 0.0A)
ASP  A 353 ( 0.6A)
 1.03A 5d0xY-3whlA:
undetectable
5d0xZ-3whlA:
undetectable		 5d0xY-3whlA:
20.59
5d0xZ-3whlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		4 / 7 ILE A 286
LEU A 308
MET A 312
LEU A 309
 ILE  A 286 ( 0.7A)
LEU  A 308 ( 0.6A)
MET  A 312 ( 0.0A)
LEU  A 309 ( 0.6A)
 1.02A 5u4sA-3whlA:
undetectable		 5u4sA-3whlA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A
(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		3 / 3 GLU A 208
ASP A 213
PRO A 214
 GLU  A 208 ( 0.6A)
ASP  A 213 ( 0.6A)
PRO  A 214 ( 1.1A)
 0.50A 6berA-3whlA:
undetectable		 6berA-3whlA:
6.60