SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3whp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3whp PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		5 / 12 PHE A 245
LEU A 188
VAL A 193
VAL A 220
ALA A 271
 None
None
None
B12  A 800 (-4.8A)
None
 1.09A 1q23H-3whpA:
undetectable
1q23I-3whpA:
undetectable		 1q23H-3whpA:
20.27
1q23I-3whpA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 3whp PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		3 / 3 THR A 202
PRO A 200
PRO A 173
 None
 0.90A 2d55C-3whpA:
undetectable		 2d55C-3whpA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 3whp PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		3 / 3 PRO A 173
THR A 202
PRO A 200
 None
 0.72A 2d55C-3whpA:
undetectable		 2d55C-3whpA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3whp PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		3 / 3 ARG A 104
PRO A 112
PHE A 103
 None
 0.88A 3thrC-3whpA:
undetectable		 3thrC-3whpA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3whp PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		5 / 9 PRO A 233
GLY A 235
ALA A 236
ARG A 208
LEU A 204
 None
 1.47A 3ur0C-3whpA:
undetectable		 3ur0C-3whpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3whp PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		5 / 12 LEU A 229
VAL A 244
LEU A 221
ALA A 236
LEU A 259
 None
 1.12A 4o1zB-3whpA:
undetectable		 4o1zB-3whpA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3whp PROBABLE
TRANSCRIPTIONAL
REGULATOR
(Thermus
thermophilus) 		5 / 12 GLY A 106
GLY A 114
ALA A 101
ARG A 105
LEU A  87
 None
 0.96A 5c0oG-3whpA:
2.6		 5c0oG-3whpA:
27.07