SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wi3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		5 / 11 SER A 233
PHE A 231
LEU A 169
LEU A 213
HIS A 222
 EDO  A 509 ( 4.3A)
None
None
EDO  A 510 (-4.7A)
EDO  A 504 ( 3.5A)
 1.27A 1e7wB-3wi3A:
undetectable		 1e7wB-3wi3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.97A 1v55P-3wi3A:
2.7
1v55W-3wi3A:
undetectable		 1v55P-3wi3A:
18.93
1v55W-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.97A 2dysC-3wi3A:
2.6
2dysJ-3wi3A:
undetectable		 2dysC-3wi3A:
18.93
2dysJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.90A 2dysP-3wi3A:
1.8
2dysW-3wi3A:
undetectable		 2dysP-3wi3A:
18.93
2dysW-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 1.00A 2eijC-3wi3A:
2.7
2eijJ-3wi3A:
undetectable		 2eijC-3wi3A:
18.93
2eijJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.96A 2eijP-3wi3A:
1.8
2eijW-3wi3A:
undetectable		 2eijP-3wi3A:
18.93
2eijW-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.97A 2eimC-3wi3A:
1.7
2eimJ-3wi3A:
undetectable		 2eimC-3wi3A:
18.93
2eimJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.94A 2einC-3wi3A:
2.6
2einJ-3wi3A:
undetectable		 2einC-3wi3A:
18.93
2einJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 1.02A 2einP-3wi3A:
1.7
2einW-3wi3A:
undetectable		 2einP-3wi3A:
18.93
2einW-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 1.02A 2zxwP-3wi3A:
1.8
2zxwW-3wi3A:
undetectable		 2zxwP-3wi3A:
18.93
2zxwW-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 1.10A 3ablC-3wi3A:
1.7
3ablJ-3wi3A:
undetectable		 3ablC-3wi3A:
18.93
3ablJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.92A 3ablP-3wi3A:
2.6
3ablW-3wi3A:
undetectable		 3ablP-3wi3A:
18.93
3ablW-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.88A 3x2qC-3wi3A:
2.7
3x2qJ-3wi3A:
undetectable		 3x2qC-3wi3A:
18.93
3x2qJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 4 ALA A 260
VAL A 264
ASP A 261
LEU A 357
 EDO  A 515 ( 3.3A)
EDO  A 514 ( 3.2A)
None
None
 1.19A 4e7gA-3wi3A:
undetectable		 4e7gA-3wi3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 266
VAL A 265
TYR A 166
TYR A 165
 EDO  A 504 ( 4.9A)
EDO  A 507 (-3.3A)
EDO  A 509 ( 4.6A)
None
 0.97A 4lb2A-3wi3A:
undetectable		 4lb2A-3wi3A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		5 / 8 LEU A 398
LEU A 279
LEU A 343
LEU A 347
ALA A 350
 None
None
None
None
EDO  A 503 (-3.9A)
 0.99A 4z90A-3wi3A:
2.8
4z90B-3wi3A:
2.6
4z90C-3wi3A:
2.8
4z90D-3wi3A:
2.5
4z90E-3wi3A:
2.7		 4z90A-3wi3A:
20.58
4z90B-3wi3A:
20.58
4z90C-3wi3A:
20.58
4z90D-3wi3A:
20.58
4z90E-3wi3A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.92A 5b1aC-3wi3A:
1.8
5b1aJ-3wi3A:
undetectable		 5b1aC-3wi3A:
18.93
5b1aJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.92A 5b1aP-3wi3A:
2.6
5b1aW-3wi3A:
undetectable		 5b1aP-3wi3A:
18.93
5b1aW-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 1.07A 5b1bC-3wi3A:
1.7
5b1bJ-3wi3A:
undetectable		 5b1bC-3wi3A:
18.93
5b1bJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.86A 5b3sC-3wi3A:
2.6
5b3sJ-3wi3A:
undetectable		 5b3sC-3wi3A:
18.93
5b3sJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.90A 5iy5C-3wi3A:
2.7
5iy5J-3wi3A:
undetectable		 5iy5C-3wi3A:
18.41
5iy5J-3wi3A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 1.04A 5z84P-3wi3A:
2.6
5z84W-3wi3A:
undetectable		 5z84P-3wi3A:
18.93
5z84W-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 1.04A 5z85P-3wi3A:
2.6
5z85W-3wi3A:
undetectable		 5z85P-3wi3A:
18.93
5z85W-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.99A 5z86C-3wi3A:
2.7
5z86J-3wi3A:
undetectable		 5z86C-3wi3A:
18.93
5z86J-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 1.03A 5z86P-3wi3A:
2.7
5z86W-3wi3A:
undetectable		 5z86P-3wi3A:
18.93
5z86W-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 1.05A 5zcoP-3wi3A:
2.6
5zcoW-3wi3A:
undetectable		 5zcoP-3wi3A:
18.93
5zcoW-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.98A 5zcpC-3wi3A:
1.7
5zcpJ-3wi3A:
undetectable		 5zcpC-3wi3A:
18.93
5zcpJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 1.02A 5zcpP-3wi3A:
2.6
5zcpW-3wi3A:
undetectable		 5zcpP-3wi3A:
18.93
5zcpW-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 169
SER A 171
PHE A 170
 None
 0.64A 6fgcA-3wi3A:
undetectable		 6fgcA-3wi3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wi3 DNA REPLICATION
REGULATOR SLD3
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.79A 6nmpC-3wi3A:
2.6
6nmpJ-3wi3A:
undetectable		 6nmpC-3wi3A:
18.93
6nmpJ-3wi3A:
12.32