SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
GLY A  76
VAL A  83
ALA A  96
VAL A 128
ASN A 196
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
MG  A 402 ( 2.9A)
ANP  A 401 (-4.8A)
 0.76A 1fmoE-3wigA:
24.2		 1fmoE-3wigA:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
ALA A  96
LYS A  98
MET A 147
GLY A 150
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.88A 1m17A-3wigA:
22.2		 1m17A-3wigA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 9 LEU A  75
GLY A  76
VAL A  83
ALA A  96
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-4.8A)
 0.52A 1muoA-3wigA:
19.5		 1muoA-3wigA:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		3 / 3 ASP A 246
LEU A 181
LEU A 178
 None
 0.79A 1np1B-3wigA:
undetectable		 1np1B-3wigA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 9 LEU A  75
VAL A  83
ALA A  96
MET A 144
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.51A 1xbbA-3wigA:
23.2		 1xbbA-3wigA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 12 ALA A  96
GLY A 150
LEU A 198
ASP A 209
PHE A 210
 ANP  A 401 (-3.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
CHU  A 403 (-3.8A)
 0.43A 1xkkA-3wigA:
24.5		 1xkkA-3wigA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 11 VAL A 155
ASP A 148
ILE A 379
LEU A 375
LEU A 198
 None
None
None
None
ANP  A 401 (-4.8A)
 1.05A 2a15A-3wigA:
undetectable		 2a15A-3wigA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 192
LEU A 207
ILE A 247
GLY A 251
SER A 253
 None
 0.98A 2aylB-3wigA:
undetectable		 2aylB-3wigA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 11 GLY A  76
VAL A  83
ALA A  96
MET A 144
SER A 151
LEU A 198
 ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-3.3A)
ANP  A 401 (-4.8A)
 0.59A 2evaA-3wigA:
24.3		 2evaA-3wigA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
GLY A  76
VAL A  83
ALA A  96
MET A 144
LYS A 193
ASN A 196
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-3.0A)
MG  A 402 ( 2.9A)
 0.99A 2fumB-3wigA:
25.7		 2fumB-3wigA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  75
VAL A  83
ALA A  96
MET A 144
ASN A 196
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
MG  A 402 ( 2.9A)
MG  A 402 (-3.2A)
 0.79A 2fumC-3wigA:
25.6		 2fumC-3wigA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  75
GLY A  76
GLY A  78
VAL A  83
ALA A  96
MET A 144
LYS A 193
ASN A 196
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-3.0A)
MG  A 402 ( 2.9A)
 1.15A 2fumD-3wigA:
26.1		 2fumD-3wigA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
VAL A  83
ALA A  96
MET A 144
LYS A 193
ASN A 196
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-3.0A)
MG  A 402 ( 2.9A)
MG  A 402 (-3.2A)
 0.84A 2fumD-3wigA:
26.1		 2fumD-3wigA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
VAL A  83
ALA A  96
VAL A 128
ILE A 142
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.57A 2gqgB-3wigA:
22.7		 2gqgB-3wigA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 6 LEU A  75
LYS A  98
VAL A 212
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 (-2.7A)
CHU  A 403 ( 4.0A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 1.19A 2hyyA-3wigA:
22.5		 2hyyA-3wigA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		4 / 6 LEU A  75
LYS A  98
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.67A 2hyyB-3wigA:
22.5		 2hyyB-3wigA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		3 / 3 HIS A  88
MET A  95
MET A  62
 None
 0.95A 2vj1A-3wigA:
undetectable		 2vj1A-3wigA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 9 LEU A  75
VAL A  83
ALA A  96
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.45A 2xp2A-3wigA:
8.3		 2xp2A-3wigA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 10 VAL A  83
ALA A  96
MET A 147
GLY A 150
LEU A 198
ASP A 209
 ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.75A 2y7jB-3wigA:
19.3		 2y7jB-3wigA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  75
ALA A  96
LYS A  98
VAL A 128
ILE A 142
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.66A 2zvaA-3wigA:
23.7		 2zvaA-3wigA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 10 LEU A  75
ALA A  96
LYS A  98
VAL A 128
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.65A 3aoxA-3wigA:
22.8		 3aoxA-3wigA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  83
ALA A  96
GLY A 150
LEU A 198
ASP A 209
PHE A 210
 ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
CHU  A 403 (-3.8A)
 0.37A 3bbtB-3wigA:
17.4		 3bbtB-3wigA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  83
ALA A  96
LYS A  98
GLY A 150
LEU A 198
ASP A 209
PHE A 210
 ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
CHU  A 403 (-3.8A)
 0.56A 3bbtD-3wigA:
24.5		 3bbtD-3wigA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
GLY A  76
ALA A  96
LYS A  98
VAL A 128
GLY A 149
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
None
ANP  A 401 (-4.8A)
 0.90A 3c7qA-3wigA:
21.6		 3c7qA-3wigA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  75
GLY A  76
ALA A  96
LYS A  98
VAL A 128
GLY A 150
LEU A 198
CYH A 208
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
CHU  A 403 ( 3.7A)
 1.10A 3c7qA-3wigA:
21.6		 3c7qA-3wigA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 10 LEU A  75
VAL A  83
LYS A  98
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.54A 3cs9A-3wigA:
22.4		 3cs9A-3wigA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 9 LEU A  75
VAL A  83
LYS A  98
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.57A 3cs9B-3wigA:
10.4		 3cs9B-3wigA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 9 LEU A  75
VAL A  83
VAL A 128
ILE A 142
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-4.8A)
 0.86A 3cs9B-3wigA:
10.4		 3cs9B-3wigA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 9 LEU A  75
VAL A  83
LYS A  98
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.59A 3cs9C-3wigA:
17.2		 3cs9C-3wigA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  75
GLY A  76
GLY A  78
VAL A  83
ALA A  96
LYS A  98
MET A 144
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
ANP  A 401 (-4.8A)
 0.67A 3eygA-3wigA:
22.6		 3eygA-3wigA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  75
GLY A  76
GLY A  78
VAL A  83
ALA A  96
MET A 144
SER A 151
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-3.3A)
ANP  A 401 (-4.8A)
 0.66A 3eygA-3wigA:
22.6		 3eygA-3wigA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
GLY A  76
GLY A  78
VAL A  83
ALA A  96
LYS A  98
MET A 144
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
 0.45A 3fupB-3wigA:
22.8		 3fupB-3wigA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
GLY A  76
GLY A  78
VAL A  83
ALA A  96
MET A 144
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-4.8A)
 0.45A 3fupB-3wigA:
22.8		 3fupB-3wigA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 11 LEU A  75
VAL A  83
ALA A  96
VAL A 128
GLY A 150
LEU A 198
CYH A 208
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
CHU  A 403 ( 3.7A)
 0.92A 3g0eA-3wigA:
21.3		 3g0eA-3wigA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
VAL A  83
ALA A  96
VAL A 128
ILE A 142
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.60A 3g5dA-3wigA:
22.6		 3g5dA-3wigA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
ALA A  96
LYS A  98
VAL A 128
ILE A 142
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.63A 3k54A-3wigA:
22.7		 3k54A-3wigA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		4 / 6 LEU A  75
LYS A  98
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.61A 3k5vA-3wigA:
21.6		 3k5vA-3wigA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		4 / 6 LEU A  75
LYS A  98
VAL A 128
ILE A 142
 ANP  A 401 (-3.8A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.63A 3k5vB-3wigA:
21.5		 3k5vB-3wigA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 192
LEU A 207
ILE A 247
GLY A 251
SER A 253
 None
 1.00A 3kk6A-3wigA:
undetectable		 3kk6A-3wigA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 192
LEU A 207
ILE A 247
GLY A 251
SER A 253
 None
 1.14A 3kk6B-3wigA:
undetectable		 3kk6B-3wigA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
GLY A  76
VAL A  83
ALA A  96
LYS A  98
VAL A 128
MET A 144
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 0.67A 3lxkA-3wigA:
22.3		 3lxkA-3wigA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
GLY A  76
GLY A  78
VAL A  83
ALA A  96
SER A 151
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-3.3A)
ANP  A 401 (-4.8A)
 0.53A 3lxnA-3wigA:
23.1		 3lxnA-3wigA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 11 ALA A  96
LYS A  98
VAL A 128
MET A 147
GLY A 150
LEU A 198
ASP A 209
 ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.75A 3miyA-3wigA:
24.2		 3miyA-3wigA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 9 ALA A  96
LYS A  98
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.45A 3miyB-3wigA:
24.0		 3miyB-3wigA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 6 VAL A  83
LYS A  98
VAL A 212
VAL A 128
ILE A 142
 ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 ( 4.0A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
 1.14A 3mssD-3wigA:
22.1		 3mssD-3wigA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_1
(TYROSINE-PROTEIN
KINASE BTK)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
VAL A  83
ALA A  96
LYS A  98
VAL A 128
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.65A 3octA-3wigA:
22.9		 3octA-3wigA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 9 LEU A  75
VAL A 212
ILE A 142
MET A 147
LEU A 198
 ANP  A 401 (-3.8A)
CHU  A 403 ( 4.0A)
CHU  A 403 (-3.8A)
None
ANP  A 401 (-4.8A)
 1.18A 3oxzA-3wigA:
15.3		 3oxzA-3wigA:
26.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 5 GLU A  63
LEU A  64
GLN A 117
HIS A 120
GLY A 132
 None
 0.57A 3pp1A-3wigA:
41.6		 3pp1A-3wigA:
87.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
VAL A  83
ALA A  96
VAL A 128
ILE A 142
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.52A 3sxrA-3wigA:
23.3		 3sxrA-3wigA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  75
VAL A  83
ALA A  96
VAL A 128
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.48A 3sxrB-3wigA:
22.9		 3sxrB-3wigA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  75
ALA A  96
LYS A  98
VAL A 128
ILE A 142
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.66A 3ue4A-3wigA:
23.1		 3ue4A-3wigA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
VAL A  83
ALA A  96
VAL A 128
ILE A 142
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.70A 3ue4B-3wigA:
23.1		 3ue4B-3wigA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		4 / 8 LEU A 102
ILE A 112
GLY A 214
ILE A 217
 None
None
PG4  A 404 (-3.4A)
CHU  A 403 (-4.0A)
 0.86A 3wxoA-3wigA:
undetectable		 3wxoA-3wigA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  75
VAL A  83
ALA A  96
LYS A  98
VAL A 128
GLY A 150
LEU A 198
CYH A 208
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
CHU  A 403 ( 3.7A)
 1.21A 4ag8A-3wigA:
22.2		 4ag8A-3wigA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 11 LEU A  75
ALA A  96
LYS A  98
GLY A 150
LEU A 198
CYH A 208
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
CHU  A 403 ( 3.7A)
 1.29A 4agdA-3wigA:
16.1		 4agdA-3wigA:
22.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LYS A  98
LEU A 116
ILE A 142
ASP A 191
LYS A 193
ASN A 196
ASP A 209
GLY A 211
 ANP  A 401 (-2.7A)
None
CHU  A 403 (-3.8A)
CHU  A 403 (-3.6A)
ANP  A 401 (-3.0A)
MG  A 402 ( 2.9A)
MG  A 402 (-3.2A)
CHU  A 403 ( 3.3A)
 1.50A 4an2A-3wigA:
40.7		 4an2A-3wigA:
94.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		11 / 12 LYS A  98
LEU A 116
LEU A 119
ILE A 142
MET A 144
ASP A 191
LYS A 193
ASN A 196
ASP A 209
GLY A 211
VAL A 212
 ANP  A 401 (-2.7A)
None
CHU  A 403 (-4.4A)
CHU  A 403 (-3.8A)
CHU  A 403 (-3.8A)
CHU  A 403 (-3.6A)
ANP  A 401 (-3.0A)
MG  A 402 ( 2.9A)
MG  A 402 (-3.2A)
CHU  A 403 ( 3.3A)
CHU  A 403 ( 4.0A)
 0.48A 4an2A-3wigA:
40.7		 4an2A-3wigA:
94.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 9 LEU A  75
VAL A  83
ALA A  96
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.41A 4anqA-3wigA:
23.0		 4anqA-3wigA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 9 LEU A  75
VAL A  83
ALA A  96
MET A 144
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.44A 4ansA-3wigA:
22.9		 4ansA-3wigA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 11 LEU A  75
GLY A  76
GLY A  78
VAL A  83
ALA A  96
GLY A 150
SER A 151
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.3A)
 0.84A 4ckiA-3wigA:
22.5		 4ckiA-3wigA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 11 LEU A  75
GLY A  76
VAL A  83
ALA A  96
GLY A 150
SER A 151
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.3A)
ANP  A 401 (-4.8A)
 0.56A 4ckiA-3wigA:
22.5		 4ckiA-3wigA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 10 LEU A  75
GLY A  76
VAL A  83
ALA A  96
SER A 151
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-3.3A)
ANP  A 401 (-4.8A)
 0.56A 4ckjA-3wigA:
22.3		 4ckjA-3wigA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  75
VAL A  83
ALA A  96
LYS A  98
MET A 147
GLY A 150
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.61A 4hjoA-3wigA:
10.2		 4hjoA-3wigA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  75
GLY A  76
VAL A  83
ALA A  96
LYS A  98
GLY A 150
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.83A 4i22A-3wigA:
23.7		 4i22A-3wigA:
26.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		12 / 12 LYS A  98
LEU A 116
LEU A 119
ILE A 142
MET A 144
ASN A 196
ASP A 209
PHE A 210
GLY A 211
SER A 213
LEU A 216
MET A 220
 ANP  A 401 (-2.7A)
None
CHU  A 403 (-4.4A)
CHU  A 403 (-3.8A)
CHU  A 403 (-3.8A)
MG  A 402 ( 2.9A)
MG  A 402 (-3.2A)
CHU  A 403 (-3.8A)
CHU  A 403 ( 3.3A)
CHU  A 403 (-4.7A)
CHU  A 403 (-4.1A)
CHU  A 403 (-3.6A)
 0.42A 4lmnA-3wigA:
41.8		 4lmnA-3wigA:
90.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 12 LEU A  75
VAL A  83
ALA A  96
LYS A  98
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.59A 4mkcA-3wigA:
23.2		 4mkcA-3wigA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
VAL A  83
ALA A  96
LYS A  98
VAL A 128
ILE A 142
GLY A 150
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
 0.70A 4mxoA-3wigA:
22.1		 4mxoA-3wigA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  75
VAL A  83
ALA A  96
LYS A  98
VAL A 128
ILE A 142
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.68A 4mxoB-3wigA:
22.2		 4mxoB-3wigA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
ALA A  96
LYS A  98
VAL A 128
ILE A 142
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.82A 4mxxA-3wigA:
22.1		 4mxxA-3wigA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  75
VAL A  83
ALA A  96
LYS A  98
VAL A 128
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.70A 4mxxB-3wigA:
16.3		 4mxxB-3wigA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 11 LEU A  75
GLY A  76
VAL A  83
ALA A  96
LYS A  98
ASN A 196
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
MG  A 402 ( 2.9A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.87A 4o0sA-3wigA:
20.5		 4o0sA-3wigA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		4 / 6 VAL A  83
ALA A  96
LYS A  98
LEU A 198
 ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
ANP  A 401 (-4.8A)
 0.49A 4o0uA-3wigA:
19.8		 4o0uA-3wigA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 6 LEU A  75
GLY A  76
VAL A  83
ALA A  96
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-4.8A)
 0.44A 4o0wA-3wigA:
20.0		 4o0wA-3wigA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		4 / 8 MET A 147
ALA A 372
LEU A 375
PHE A 337
 None
CL  A 407 ( 4.3A)
None
None
 1.05A 4rkuA-3wigA:
undetectable
4rkuJ-3wigA:
undetectable		 4rkuA-3wigA:
18.51
4rkuJ-3wigA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 11 LEU A  75
GLY A  78
VAL A  83
ALA A  96
MET A 147
GLY A 150
ASN A 196
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
None
ANP  A 401 ( 4.3A)
MG  A 402 ( 2.9A)
ANP  A 401 (-4.8A)
 0.74A 4u5jA-3wigA:
23.3		 4u5jA-3wigA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 9 LEU A  75
VAL A  83
ALA A  96
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.51A 4u5jB-3wigA:
23.0		 4u5jB-3wigA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 11 LEU A  75
ALA A  96
MET A 147
GLY A 150
ASN A 196
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
None
ANP  A 401 ( 4.3A)
MG  A 402 ( 2.9A)
ANP  A 401 (-4.8A)
 0.81A 4wa9A-3wigA:
21.1		 4wa9A-3wigA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		4 / 8 LEU A  75
ALA A  96
MET A 144
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-4.8A)
 0.54A 4wboB-3wigA:
7.7		 4wboB-3wigA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 6 LEU A  75
ALA A  96
MET A 144
MET A 147
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
None
ANP  A 401 (-4.8A)
 0.57A 4wboC-3wigA:
23.2		 4wboC-3wigA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  75
VAL A  83
ALA A  96
LYS A  98
VAL A 128
ILE A 142
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.64A 4xeyA-3wigA:
23.5		 4xeyA-3wigA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
VAL A  83
LYS A  98
VAL A 128
ILE A 142
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.61A 4xeyB-3wigA:
23.2		 4xeyB-3wigA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  83
ALA A  96
LYS A  98
VAL A 128
ILE A 142
GLY A 150
LEU A 198
 ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.45A 4xeyB-3wigA:
23.2		 4xeyB-3wigA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 9 LEU A  75
VAL A  83
ALA A  96
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.49A 5aaaA-3wigA:
23.1		 5aaaA-3wigA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 10 LEU A  75
VAL A  83
ALA A  96
LYS A  98
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.63A 5aabA-3wigA:
23.3		 5aabA-3wigA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 10 LEU A  75
VAL A  83
ALA A  96
LYS A  98
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.52A 5aacA-3wigA:
23.0		 5aacA-3wigA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		3 / 3 ILE A 142
MET A 147
ASP A 209
 CHU  A 403 (-3.8A)
None
MG  A 402 (-3.2A)
 0.69A 5h2uA-3wigA:
18.9		 5h2uA-3wigA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
VAL A  83
ALA A  96
ILE A 142
GLY A 150
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.65A 5h2uB-3wigA:
26.2		 5h2uB-3wigA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
ALA A  96
LYS A  98
ILE A 142
GLY A 150
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.70A 5h2uC-3wigA:
26.1		 5h2uC-3wigA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 LEU A  75
VAL A  83
ALA A  96
ILE A 142
GLY A 150
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.62A 5h2uD-3wigA:
26.0		 5h2uD-3wigA:
29.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 12 GLY A  76
VAL A  83
ALA A  96
VAL A 128
HIS A 146
LEU A 198
 ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
ANP  A 401 ( 4.9A)
ANP  A 401 (-4.8A)
 0.87A 5l2tA-3wigA:
7.2		 5l2tA-3wigA:
31.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 11 LEU A  75
GLY A  76
VAL A  83
ALA A  96
VAL A 128
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
ANP  A 401 (-4.8A)
 0.62A 5lvnA-3wigA:
24.2		 5lvnA-3wigA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 9 GLY A  76
VAL A  83
ALA A  96
MET A 144
MET A 147
 ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
None
 0.41A 5lw1B-3wigA:
21.4		 5lw1B-3wigA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 10 GLY A  76
VAL A  83
ALA A  96
MET A 144
MET A 147
 ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
None
 0.42A 5lw1E-3wigA:
21.3		 5lw1E-3wigA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 9 GLY A  76
VAL A  83
ALA A  96
MET A 144
MET A 147
 ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
None
 0.30A 5lw1H-3wigA:
21.4		 5lw1H-3wigA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 10 LEU A  75
VAL A  83
ILE A 142
MET A 147
GLY A 150
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
CHU  A 403 (-3.8A)
None
ANP  A 401 ( 4.3A)
 0.70A 5mo4A-3wigA:
18.8		 5mo4A-3wigA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 10 LEU A  75
VAL A  83
LYS A  98
ILE A 142
GLY A 149
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
None
 0.67A 5mo4A-3wigA:
18.8		 5mo4A-3wigA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 10 LEU A  75
VAL A  83
ALA A  96
VAL A 128
MET A 144
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-4.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-4.8A)
 0.84A 5n3hA-3wigA:
24.2		 5n3hA-3wigA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 205
LEU A 152
TRP A 374
GLY A 203
GLY A 149
 None
None
None
CL  A 407 ( 4.4A)
None
 1.19A 5nnaA-3wigA:
undetectable		 5nnaA-3wigA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 205
LEU A 152
TRP A 374
GLY A 203
GLY A 149
 None
None
None
CL  A 407 ( 4.4A)
None
 1.21A 5nnaB-3wigA:
undetectable		 5nnaB-3wigA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		5 / 12 ILE A 205
LEU A 152
TRP A 374
GLY A 203
GLY A 149
 None
None
None
CL  A 407 ( 4.4A)
None
 1.18A 5nnaD-3wigA:
undetectable		 5nnaD-3wigA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  83
ALA A  96
LYS A  98
ILE A 142
GLY A 150
LEU A 198
PHE A 210
 ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
CHU  A 403 (-3.8A)
 0.53A 5p9iA-3wigA:
25.7		 5p9iA-3wigA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		3 / 3 LYS A  89
PRO A  90
LYS A  65
 None
 1.17A 5y9yA-3wigA:
undetectable		 5y9yA-3wigA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		8 / 12 LEU A  75
GLY A  76
VAL A  83
ALA A  96
LYS A  98
MET A 144
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.83A 5yu9A-3wigA:
23.4		 5yu9A-3wigA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 GLY A  76
VAL A  83
ALA A  96
LYS A  98
MET A 144
ASP A 153
LEU A 198
 ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
None
ANP  A 401 (-4.8A)
 1.27A 5yu9B-3wigA:
23.3		 5yu9B-3wigA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 GLY A  76
VAL A  83
ALA A  96
LYS A  98
MET A 144
LEU A 198
ASP A 209
 ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.81A 5yu9B-3wigA:
23.3		 5yu9B-3wigA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  83
ALA A  96
LYS A  98
MET A 144
GLY A 150
ASP A 209
 ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
MG  A 402 (-3.2A)
 0.76A 5yu9C-3wigA:
23.4		 5yu9C-3wigA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		6 / 12 VAL A  83
ALA A  96
LYS A  98
GLY A 150
LEU A 198
ASP A 209
 ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.51A 5yu9D-3wigA:
24.0		 5yu9D-3wigA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  83
ALA A  96
LYS A  98
MET A 144
GLY A 150
ASP A 153
LEU A 198
 ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
None
ANP  A 401 (-4.8A)
 1.31A 5yu9D-3wigA:
24.0		 5yu9D-3wigA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		4 / 6 PHE A 337
VAL A 174
LEU A 352
LEU A 355
 None
 0.70A 6e43A-3wigA:
undetectable		 6e43A-3wigA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		4 / 6 PHE A 337
VAL A 174
LEU A 352
LEU A 355
 None
 0.67A 6e43B-3wigA:
undetectable		 6e43B-3wigA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		4 / 6 PHE A 337
VAL A 174
LEU A 352
LEU A 355
 None
 0.70A 6e43C-3wigA:
undetectable		 6e43C-3wigA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		4 / 6 PHE A 337
VAL A 174
LEU A 352
LEU A 355
 None
 0.75A 6e43D-3wigA:
undetectable		 6e43D-3wigA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens) 		7 / 12 VAL A  83
ALA A  96
LYS A  98
ILE A 142
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.43A 6fnmA-3wigA:
23.4		 6fnmA-3wigA:
26.23