SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3wih ANTI-HUMAN ROBO1
ANTIBODY B2212A FAB
HEAVY CHAIN
(Mus
musculus) 		3 / 3 GLU H   1
ASP H 107
TYR H  32
 None
 0.77A 2yvlB-3wihH:
undetectable		 2yvlB-3wihH:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3wih ROUNDABOUT HOMOLOG 1
(Homo
sapiens) 		5 / 12 GLY A  18
ASN A  17
GLY A  16
ILE A  66
LEU A  69
 None
 1.09A 3ihtA-3wihA:
undetectable		 3ihtA-3wihA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 3wih ANTI-HUMAN ROBO1
ANTIBODY B2212A FAB
HEAVY CHAIN
ROUNDABOUT HOMOLOG 1
(Homo
sapiens;
Mus
musculus) 		3 / 3 ARG A  50
TYR H  32
ASN H  35
 None
 0.86A 4ffwB-3wihA:
undetectable		 4ffwB-3wihA:
10.09