SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wiw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 4 GLY A 362
ASP A 305
GLY A 247
THR A 234
 None
 0.67A 1hxbB-3wiwA:
undetectable		 1hxbB-3wiwA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 7 TYR A 255
VAL A 171
ILE A 220
HIS A 270
 None
 0.92A 1j96B-3wiwA:
undetectable		 1j96B-3wiwA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		3 / 3 ASP A 116
THR A  74
GLU A 369
 EPE  A 501 (-2.8A)
None
None
 0.69A 1pj7A-3wiwA:
undetectable		 1pj7A-3wiwA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		5 / 12 LEU A 138
LEU A 141
ALA A 145
LEU A 182
TYR A 122
 None
 0.85A 1s9pA-3wiwA:
undetectable		 1s9pA-3wiwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		5 / 12 LEU A 138
LEU A 141
ALA A 145
LEU A 182
TYR A 122
 None
 0.88A 1s9pD-3wiwA:
undetectable		 1s9pD-3wiwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		5 / 7 MET A 284
PHE A 294
ALA A 245
ALA A 249
LEU A 316
 None
 1.35A 2wx2A-3wiwA:
undetectable		 2wx2A-3wiwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		5 / 8 MET A 284
PHE A 294
ALA A 245
ALA A 249
LEU A 316
 None
 1.19A 2wx2B-3wiwA:
undetectable		 2wx2B-3wiwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 GLN A 236
GLN A 248
ASP A 293
SER A 242
 EPE  A 501 ( 4.3A)
None
None
None
 1.22A 2xz5C-3wiwA:
undetectable
2xz5D-3wiwA:
undetectable		 2xz5C-3wiwA:
19.63
2xz5D-3wiwA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 6 ASP A 395
ILE A 394
LEU A  32
GLU A 390
 None
 1.08A 2ya7A-3wiwA:
undetectable		 2ya7A-3wiwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 4 GLY A 362
ASP A 305
GLY A 247
THR A 234
 None
 0.72A 3k4vC-3wiwA:
undetectable		 3k4vC-3wiwA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 PHE A 294
ALA A 245
ALA A 249
LEU A 316
 None
 0.78A 3l4dA-3wiwA:
undetectable		 3l4dA-3wiwA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 PHE A 294
ALA A 245
ALA A 249
LEU A 316
 None
 0.81A 3l4dD-3wiwA:
undetectable		 3l4dD-3wiwA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 7 PRO A 290
LEU A 340
LEU A 337
ILE A 312
 None
 0.84A 3u5jA-3wiwA:
undetectable		 3u5jA-3wiwA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 ASP A  72
ASP A 174
GLU A 369
ASP A 116
 None
EPE  A 501 (-3.9A)
None
EPE  A 501 (-2.8A)
 1.20A 4feuF-3wiwA:
undetectable		 4feuF-3wiwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 7 ASP A  72
ASP A 174
GLU A 369
ASP A 116
 None
EPE  A 501 (-3.9A)
None
EPE  A 501 (-2.8A)
 1.19A 4fevD-3wiwA:
undetectable		 4fevD-3wiwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 7 ASP A  72
ASP A 174
GLU A 369
ASP A 116
 None
EPE  A 501 (-3.9A)
None
EPE  A 501 (-2.8A)
 1.20A 4fevF-3wiwA:
undetectable		 4fevF-3wiwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 ASP A  72
ASP A 174
GLU A 369
ASP A 116
 None
EPE  A 501 (-3.9A)
None
EPE  A 501 (-2.8A)
 1.21A 4fewD-3wiwA:
undetectable		 4fewD-3wiwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 7 ASP A  72
ASP A 174
GLU A 369
ASP A 116
 None
EPE  A 501 (-3.9A)
None
EPE  A 501 (-2.8A)
 1.21A 4fexB-3wiwA:
undetectable		 4fexB-3wiwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 ASP A  72
ASP A 174
GLU A 369
ASP A 116
 None
EPE  A 501 (-3.9A)
None
EPE  A 501 (-2.8A)
 1.18A 4gkhB-3wiwA:
undetectable		 4gkhB-3wiwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 7 ASP A  72
ASP A 174
GLU A 369
ASP A 116
 None
EPE  A 501 (-3.9A)
None
EPE  A 501 (-2.8A)
 1.19A 4gkhG-3wiwA:
undetectable		 4gkhG-3wiwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 ASP A  72
ASP A 174
GLU A 369
ASP A 116
 None
EPE  A 501 (-3.9A)
None
EPE  A 501 (-2.8A)
 1.20A 4gkiA-3wiwA:
undetectable		 4gkiA-3wiwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 ASP A  72
ASP A 174
GLU A 369
ASP A 116
 None
EPE  A 501 (-3.9A)
None
EPE  A 501 (-2.8A)
 1.20A 4gkiC-3wiwA:
undetectable		 4gkiC-3wiwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 ARG A 246
TYR A 376
ARG A  57
ARG A  66
 None
 1.39A 4kr4C-3wiwA:
undetectable		 4kr4C-3wiwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		5 / 12 ALA A 308
ASP A 287
ILE A 289
ARG A 304
ASP A 305
 None
 1.02A 4m2xA-3wiwA:
undetectable		 4m2xA-3wiwA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		3 / 3 GLU A 369
ARG A  66
GLN A 236
 None
None
EPE  A 501 ( 4.3A)
 0.90A 4rtbA-3wiwA:
undetectable		 4rtbA-3wiwA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		3 / 3 GLU A  97
ALA A  98
PHE A 101
 None
 0.19A 4v1fA-3wiwA:
undetectable		 4v1fA-3wiwA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		3 / 3 GLU A  97
ALA A  98
PHE A 101
 None
 0.22A 4v1fC-3wiwA:
undetectable		 4v1fC-3wiwA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 6 ALA A 308
SER A 307
GLN A 236
ASP A 293
 None
None
EPE  A 501 ( 4.3A)
None
 1.20A 5c6pA-3wiwA:
undetectable		 5c6pA-3wiwA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 ALA A 315
VAL A 311
TYR A 380
GLU A 180
 None
 0.84A 5ecnD-3wiwA:
undetectable		 5ecnD-3wiwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 7 GLY A  76
GLY A  80
PHE A 119
ASP A 116
 None
None
None
EPE  A 501 (-2.8A)
 0.81A 5ergB-3wiwA:
undetectable		 5ergB-3wiwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 6 GLU A 188
THR A 132
TYR A 129
PHE A 189
 None
 1.38A 5lrbA-3wiwA:
undetectable		 5lrbA-3wiwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 HIS A 209
SER A 258
LEU A 179
SER A 161
 None
 0.88A 5m8rB-3wiwA:
undetectable		 5m8rB-3wiwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 HIS A 209
SER A 258
LEU A 179
SER A 161
 None
 0.83A 5m8rD-3wiwA:
undetectable		 5m8rD-3wiwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 4 SER A 314
ALA A 315
GLN A 322
THR A 256
 None
 1.41A 5n0rA-3wiwA:
undetectable		 5n0rA-3wiwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 4 SER A 314
ALA A 315
GLN A 322
THR A 256
 None
 1.38A 5n0sA-3wiwA:
undetectable		 5n0sA-3wiwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 5 SER A 314
ALA A 315
GLN A 322
THR A 256
 None
 1.40A 5n0tA-3wiwA:
undetectable		 5n0tA-3wiwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 4 SER A 314
ALA A 315
GLN A 322
THR A 256
 None
 1.38A 5n0wA-3wiwA:
undetectable		 5n0wA-3wiwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 5 SER A 314
ALA A 315
GLN A 322
THR A 256
 None
 1.37A 5n0wB-3wiwA:
undetectable		 5n0wB-3wiwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 4 SER A 314
ALA A 315
GLN A 322
THR A 256
 None
 1.40A 5n0xA-3wiwA:
undetectable		 5n0xA-3wiwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 5 SER A 314
ALA A 315
GLN A 322
THR A 256
 None
 1.38A 5n4iA-3wiwA:
undetectable		 5n4iA-3wiwA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		6 / 11 LEU A 252
GLY A 254
GLU A 180
LEU A 316
GLU A 383
ALA A 315
 None
 1.32A 5o96G-3wiwA:
undetectable		 5o96G-3wiwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 THR A 200
THR A 205
VAL A 229
TYR A 222
 None
 1.28A 5ov9B-3wiwA:
undetectable		 5ov9B-3wiwA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		5 / 9 LEU A  94
ALA A  98
VAL A 131
GLY A  90
THR A 398
 None
 1.50A 5w5vA-3wiwA:
undetectable		 5w5vA-3wiwA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		5 / 10 MET A 284
PHE A 294
ALA A 245
ALA A 249
LEU A 316
 None
 1.29A 6ay4A-3wiwA:
undetectable		 6ay4A-3wiwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 3wiw GLYCOSYL HYDROLASE
FAMILY 88
(Pedobacter
heparinus) 		4 / 8 ALA A 271
GLY A 251
LEU A 252
ALA A 315
 None
 0.49A 6mdqA-3wiwA:
1.6		 6mdqA-3wiwA:
13.65