SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wj2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		6 / 12 GLY A  84
GLY A  85
GLY A  86
SER A 156
PHE A 213
HIS A 281
 None
 0.95A 1dx6A-3wj2A:
16.7		 1dx6A-3wj2A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		4 / 8 ARG A 275
GLU A 258
SER A 195
TYR A 199
 None
 1.34A 1nx9B-3wj2A:
16.4		 1nx9B-3wj2A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		6 / 12 GLY A  84
GLY A  85
GLY A  86
SER A 156
PHE A 213
HIS A 281
 None
 0.97A 1qtiA-3wj2A:
3.1		 1qtiA-3wj2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		6 / 12 GLY A  84
GLY A  85
GLY A  86
SER A 156
PHE A 213
HIS A 281
 None
 0.97A 1w6rA-3wj2A:
4.9		 1w6rA-3wj2A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 11 GLY A  84
GLY A  85
SER A 156
PHE A  89
HIS A 281
 None
 1.11A 1w76A-3wj2A:
16.2		 1w76A-3wj2A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 11 GLY A  85
GLY A  86
SER A 156
PHE A 213
HIS A 281
 None
 0.98A 1w76A-3wj2A:
16.2		 1w76A-3wj2A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 10 GLY A  84
GLY A  85
SER A 156
PHE A 213
HIS A 281
 None
 0.90A 1w76B-3wj2A:
15.8		 1w76B-3wj2A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		6 / 9 GLY A  84
GLY A  85
SER A 156
ALA A 157
PHE A  89
HIS A 281
 None
 1.15A 2aceA-3wj2A:
4.6		 2aceA-3wj2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 9 GLY A  85
GLY A  86
SER A 156
ALA A 157
HIS A 281
 None
 0.43A 2aceA-3wj2A:
4.6		 2aceA-3wj2A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 8 GLY A  84
GLY A  85
ALA A 157
PHE A  89
HIS A 281
 None
 1.08A 2ha4A-3wj2A:
7.9		 2ha4A-3wj2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		4 / 8 GLY A  85
GLY A  86
ALA A 157
HIS A 281
 None
 0.30A 2ha4A-3wj2A:
7.9		 2ha4A-3wj2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		4 / 7 GLY A  85
GLY A  86
ALA A 157
HIS A 281
 None
 0.25A 2ha4B-3wj2A:
16.7		 2ha4B-3wj2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		6 / 12 PHE A  87
GLY A  86
GLY A  84
ILE A 113
ASN A 160
LEU A 165
 None
 1.23A 2nxeA-3wj2A:
2.3		 2nxeA-3wj2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 10 SER A 186
HIS A 281
ALA A 157
ASN A 160
ALA A 159
 None
 1.35A 2r2vC-3wj2A:
undetectable
2r2vF-3wj2A:
undetectable
2r2vG-3wj2A:
undetectable		 2r2vC-3wj2A:
8.50
2r2vF-3wj2A:
8.50
2r2vG-3wj2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
 None
 1.13A 3keeD-3wj2A:
undetectable		 3keeD-3wj2A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		4 / 7 GLY A  85
GLY A  86
SER A 156
HIS A 281
 None
 0.42A 3o9mA-3wj2A:
2.8		 3o9mA-3wj2A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		4 / 6 GLY A  85
GLY A  86
SER A 156
HIS A 281
 None
 0.47A 3o9mB-3wj2A:
7.5		 3o9mB-3wj2A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		4 / 8 LEU A 161
ALA A 157
SER A 186
TYR A 217
 None
 1.12A 3rodA-3wj2A:
undetectable		 3rodA-3wj2A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
 None
 1.04A 3sueA-3wj2A:
undetectable		 3sueA-3wj2A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
 None
 1.02A 3sueB-3wj2A:
undetectable		 3sueB-3wj2A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
 None
 1.09A 3sueC-3wj2A:
undetectable		 3sueC-3wj2A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
 None
 1.06A 3sufA-3wj2A:
undetectable		 3sufA-3wj2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
 None
 1.00A 3sufB-3wj2A:
undetectable		 3sufB-3wj2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 11 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
 None
 1.16A 3sufC-3wj2A:
undetectable		 3sufC-3wj2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 HIS A 281
GLY A  86
GLY A  84
TYR A 184
ALA A 118
 None
 1.23A 3vywD-3wj2A:
undetectable		 3vywD-3wj2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 ASP A 155
PHE A  89
HIS A  83
GLY A 158
TYR A 115
 None
 1.25A 4bz6A-3wj2A:
undetectable
4bz6B-3wj2A:
undetectable		 4bz6A-3wj2A:
21.40
4bz6B-3wj2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 ASP A 155
PHE A  89
HIS A  83
GLY A 158
TYR A 115
 None
 1.26A 4bz6C-3wj2A:
undetectable		 4bz6C-3wj2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		6 / 12 GLY A  84
GLY A  85
GLY A  86
SER A 156
PHE A 213
HIS A 281
 None
 0.97A 4ey6A-3wj2A:
17.5		 4ey6A-3wj2A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		6 / 12 GLY A  84
GLY A  85
GLY A  86
SER A 156
PHE A 213
HIS A 281
 None
 0.97A 4ey6B-3wj2A:
17.2		 4ey6B-3wj2A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		4 / 5 TYR A 115
SER A 112
ASP A 155
ASP A 286
 None
 1.47A 4qtuB-3wj2A:
3.0		 4qtuB-3wj2A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 ALA A 153
ALA A 103
ILE A 110
LEU A 308
GLY A 151
 None
 0.97A 4r38A-3wj2A:
undetectable		 4r38A-3wj2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 ALA A 153
ALA A 103
ILE A 110
LEU A 308
GLY A 151
 None
 0.97A 4r38C-3wj2A:
undetectable		 4r38C-3wj2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 ALA A 153
ALA A 103
ILE A 110
LEU A 308
GLY A 151
 None
 0.99A 4r38D-3wj2A:
undetectable		 4r38D-3wj2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 ALA A 153
ALA A 103
ILE A 110
LEU A 308
GLY A 151
 None
 0.99A 4r3aB-3wj2A:
undetectable		 4r3aB-3wj2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 SER A 156
GLY A 214
GLY A 207
LEU A 205
PRO A 252
 None
 1.18A 4uilH-3wj2A:
undetectable
4uilL-3wj2A:
undetectable		 4uilH-3wj2A:
18.50
4uilL-3wj2A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		4 / 7 ILE A  92
ILE A 111
ILE A  58
LEU A  80
 None
 0.80A 5fukA-3wj2A:
undetectable
5fukB-3wj2A:
undetectable		 5fukA-3wj2A:
21.67
5fukB-3wj2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 8 GLY A 282
ASP A 251
VAL A   7
GLY A 276
ILE A 296
 None
 1.27A 5kr1B-3wj2A:
undetectable		 5kr1B-3wj2A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		3 / 3 TYR A 217
LEU A 117
ASP A  37
 None
 0.88A 5zv2B-3wj2A:
undetectable		 5zv2B-3wj2A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		4 / 7 ASN A  66
ASN A  91
GLU A  93
ARG A  68
 None
 1.12A 6b8kA-3wj2A:
undetectable		 6b8kA-3wj2A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 12 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
 None
 1.08A 6c2mC-3wj2A:
undetectable		 6c2mC-3wj2A:
10.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IEY_A_CLMA401_0
(ESTERASE)		 3wj2 CARBOXYLESTERASE
(Ferroplasma
acidiphilum) 		5 / 11 ASP A 155
LEU A 205
HIS A 281
GLY A 282
PHE A  89
 None
 0.94A 6ieyA-3wj2A:
39.0
6ieyB-3wj2A:
39.0		 6ieyA-3wj2A:
35.20
6ieyB-3wj2A:
35.20