SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wj9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		5 / 9 VAL A 231
GLY A 246
ALA A 182
THR A 248
SER A 174
 None
 1.16A 1gtnL-3wj9A:
undetectable
1gtnM-3wj9A:
undetectable		 1gtnL-3wj9A:
12.10
1gtnM-3wj9A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  17
ASN A  19
ALA A  20
LEU A 369
THR A  62
 None
 1.29A 1ya3A-3wj9A:
undetectable		 1ya3A-3wj9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		5 / 12 GLU A  63
LEU A  17
GLY A  46
LYS A  86
ALA A  50
 None
 1.12A 2kceA-3wj9A:
undetectable		 2kceA-3wj9A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  17
ASN A  19
ALA A  20
LEU A 369
THR A  62
 None
 1.27A 2oaxB-3wj9A:
undetectable		 2oaxB-3wj9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  17
ASN A  19
ALA A  20
LEU A 369
THR A  62
 None
 1.26A 2oaxC-3wj9A:
undetectable		 2oaxC-3wj9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR A  51
GLY A  16
SER A  14
ILE A  15
 None
 0.92A 3ihzB-3wj9A:
undetectable		 3ihzB-3wj9A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		3 / 3 LYS A 107
GLU A  92
TRP A  91
 None
 1.38A 3v4tH-3wj9A:
undetectable		 3v4tH-3wj9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		3 / 3 GLY A 226
GLU A 247
THR A 248
 None
 0.56A 4kouA-3wj9A:
undetectable		 4kouA-3wj9A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		3 / 3 ASN A 277
PHE A 297
TYR A 245
 None
 0.86A 4u15A-3wj9A:
undetectable		 4u15A-3wj9A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 330
LEU A 325
ILE A 348
GLY A 390
THR A 357
 None
 1.11A 4ze2A-3wj9A:
undetectable		 4ze2A-3wj9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		3 / 3 PRO A 319
ILE A 285
SER A 362
 None
 0.56A 5fsaA-3wj9A:
undetectable		 5fsaA-3wj9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		4 / 7 ILE A 285
PHE A 283
TRP A 276
SER A 228
 None
 1.19A 5nr3A-3wj9A:
undetectable		 5nr3A-3wj9A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		5 / 10 PHE A 171
ILE A 200
ALA A 180
LEU A 173
ALA A 172
 None
 1.39A 5oy0b-3wj9A:
undetectable		 5oy0b-3wj9A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A
(Schizosaccharomy
ces
pombe) 		4 / 6 TYR A 244
VAL A 195
VAL A 218
THR A 233
 None
 1.36A 6f32B-3wj9A:
undetectable		 6f32B-3wj9A:
20.00