SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wjp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		3 / 3 ASP A  39
LEU A  28
LEU A  25
 None
 0.72A 1ikeA-3wjpA:
undetectable		 1ikeA-3wjpA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		3 / 3 ARG A 236
ASP A  43
ASN A  83
 None
MG  A 404 ( 3.1A)
None
 0.78A 1nbhA-3wjpA:
undetectable		 1nbhA-3wjpA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		3 / 3 ARG A 236
ASP A  43
ASN A  83
 None
MG  A 404 ( 3.1A)
None
 0.75A 1nbhD-3wjpA:
undetectable		 1nbhD-3wjpA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		3 / 3 ASP A  39
LEU A  28
LEU A  25
 None
 0.78A 1np1B-3wjpA:
undetectable		 1np1B-3wjpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 177
GLY A 174
SER A 259
GLU A 185
PRO A 333
 None
None
PGE  A 417 (-2.8A)
None
None
 0.95A 1sg9B-3wjpA:
undetectable		 1sg9B-3wjpA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		5 / 12 GLY A  89
ALA A  90
ILE A 149
ILE A  54
ILE A  36
 None
None
None
None
GOL  A 414 (-4.6A)
 0.77A 1sguB-3wjpA:
undetectable		 1sguB-3wjpA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		4 / 5 LEU A 231
GLY A 174
PRO A 222
ALA A 230
 None
 0.96A 2aohA-3wjpA:
undetectable		 2aohA-3wjpA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		5 / 12 GLY A  89
ALA A  90
ILE A 149
ILE A  54
ILE A  36
 None
None
None
None
GOL  A 414 (-4.6A)
 0.87A 2b60A-3wjpA:
undetectable		 2b60A-3wjpA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		5 / 12 GLY A  60
GLY A 131
ASN A  97
ALA A  96
ALA A  94
 None
 1.02A 2bm9F-3wjpA:
undetectable		 2bm9F-3wjpA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		4 / 6 ALA A 247
ASP A 248
GLU A 246
ARG A 324
 None
 1.38A 2ouzA-3wjpA:
undetectable		 2ouzA-3wjpA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		5 / 6 MET A 326
VAL A 314
ILE A 249
ILE A 242
LEU A 243
 None
 1.46A 3hegA-3wjpA:
undetectable		 3hegA-3wjpA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		4 / 7 GLY A 312
ALA A 235
ALA A 159
ASP A 158
 None
 0.84A 3ur0B-3wjpA:
1.2		 3ur0B-3wjpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		5 / 12 THR A  62
GLU A 141
LEU A  66
HIS A 176
LEU A  76
 QCS  A 338 ( 3.6A)
GOL  A 415 ( 4.5A)
None
None
None
 1.29A 4xi3D-3wjpA:
undetectable		 4xi3D-3wjpA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 273
GLY A  80
SER A  79
ASP A  59
GLY A 174
 None
None
None
MG  A 403 (-2.6A)
None
 1.07A 5hikA-3wjpA:
undetectable		 5hikA-3wjpA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		4 / 4 GLY A 297
ALA A 290
MET A 277
THR A 210
 None
 1.17A 5n0sB-3wjpA:
undetectable		 5n0sB-3wjpA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		5 / 11 VAL A 163
GLY A 164
GLU A 305
ASP A 309
ALA A 308
 None
 1.13A 5x6yA-3wjpA:
undetectable		 5x6yA-3wjpA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		5 / 10 VAL A 163
GLY A 164
GLU A 305
ASP A 309
ALA A 308
 None
 1.12A 5x6yB-3wjpA:
undetectable		 5x6yB-3wjpA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		5 / 12 LEU A  38
GLY A  44
ALA A  40
ASP A  43
THR A  57
 ANP  A 401 (-4.3A)
None
GOL  A 414 (-3.4A)
MG  A 404 ( 3.1A)
None
 1.23A 5x6yC-3wjpA:
undetectable		 5x6yC-3wjpA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE
(Thermococcus
kodakarensis) 		4 / 5 LEU A  85
THR A  57
THR A  46
GLY A  44
 None
 1.16A 6gtqA-3wjpA:
undetectable		 6gtqA-3wjpA:
20.54