SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 5 THR A 128
GLU A 103
THR A  98
HIS A 233
 LLP  A 234 ( 4.3A)
None
None
LLP  A 234 ( 3.5A)
 1.39A 1d4fB-3wksA:
undetectable		 1d4fB-3wksA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ALA A 210
VAL A 229
ALA A 101
HIS A 233
 LLP  A 234 ( 3.4A)
None
LLP  A 234 ( 3.5A)
LLP  A 234 ( 3.5A)
 1.14A 1q23F-3wksA:
undetectable		 1q23F-3wksA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 10 PHE A  82
GLY A 232
GLY A 100
THR A  98
ALA A 101
 None
LLP  A 234 ( 4.3A)
LLP  A 234 ( 3.1A)
None
LLP  A 234 ( 3.5A)
 1.11A 2ej3B-3wksA:
undetectable		 2ej3B-3wksA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 6 PHE A  89
ARG A 215
GLY A 214
LYS A 235
 None
LLP  A 234 ( 3.9A)
None
LLP  A 234 ( 3.6A)
 1.44A 2i30A-3wksA:
undetectable		 2i30A-3wksA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 10 SER A 235
HIS A 233
ALA A 210
ALA A 230
ALA A 101
 LLP  A 234 ( 3.2A)
LLP  A 234 ( 3.5A)
LLP  A 234 ( 3.4A)
None
LLP  A 234 ( 3.5A)
 1.22A 2r2vC-3wksA:
undetectable
2r2vF-3wksA:
undetectable
2r2vG-3wksA:
undetectable		 2r2vC-3wksA:
7.14
2r2vF-3wksA:
7.14
2r2vG-3wksA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ARG A 135
LEU A 206
ILE A 107
ALA A 111
LEU A 138
 None
 1.21A 2v0mA-3wksA:
undetectable		 2v0mA-3wksA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 245
ALA A 230
LEU A 206
GLY A 220
LEU A  90
 None
 1.25A 3uudA-3wksA:
undetectable		 3uudA-3wksA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 197
ILE A 176
VAL A 119
LEU A 175
VAL A 108
 None
 1.08A 3w67A-3wksA:
undetectable		 3w67A-3wksA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 PRO A 217
VAL A 289
HIS A 288
 None
 0.69A 4pevC-3wksA:
3.8		 4pevC-3wksA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A 245
GLU A 268
MET A 109
LEU A 175
 None
 1.16A 4xi3B-3wksA:
undetectable		 4xi3B-3wksA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 VAL A 140
TYR A 130
ALA A 133
 None
 0.52A 4ybnA-3wksA:
undetectable		 4ybnA-3wksA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 9 TYR A 159
ILE A 163
GLY A 158
ILE A 197
ALA A 198
 None
 1.29A 4yp2B-3wksA:
undetectable		 4yp2B-3wksA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A 315
VAL A 392
ILE A 369
LEU A 310
PHE A 349
 None
 1.17A 5im2A-3wksA:
undetectable		 5im2A-3wksA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLY A 375
GLN A 380
LYS A 302
 None
 0.98A 5imsB-3wksA:
3.7		 5imsB-3wksA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ILE A  79
ALA A 238
SER A 285
VAL A 280
ILE A 279
 None
 1.37A 5mlmA-3wksA:
3.2		 5mlmA-3wksA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 5 HIS A 233
ALA A 210
SER A 231
GLY A 100
 LLP  A 234 ( 3.5A)
LLP  A 234 ( 3.4A)
LLP  A 234 ( 2.9A)
LLP  A 234 ( 3.1A)
 1.21A 5yodB-3wksA:
undetectable		 5yodB-3wksA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 373
PHE A 349
ILE A 391
VAL A 392
VAL A 384
 None
 1.30A 6ap6A-3wksA:
2.2		 6ap6A-3wksA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 373
PHE A 349
ILE A 391
VAL A 392
VAL A 384
 None
 1.28A 6ap6B-3wksA:
2.2		 6ap6B-3wksA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A 159
ASN A 189
LEU A 178
 None
 0.66A 6b58A-3wksA:
undetectable		 6b58A-3wksA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE
(Methanocaldococc
us
jannaschii) 		4 / 7 GLN A  41
GLY A  44
VAL A 289
SER A 231
 None
LLP  A 234 ( 4.3A)
None
LLP  A 234 ( 2.9A)
 1.06A 6hu9S-3wksA:
undetectable
6hu9q-3wksA:
undetectable		 6hu9S-3wksA:
12.37
6hu9q-3wksA:
14.18