SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wl4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 HIS A  40
PHE A 219
HIS A 151
ASP A  43
ASP A  42
 CD  A 301 ( 3.4A)
HEZ  A 315 ( 4.4A)
CD  A 301 ( 3.5A)
CD  A 301 ( 2.1A)
TAM  A 309 (-2.7A)
 1.04A 1a4lC-3wl4A:
undetectable		 1a4lC-3wl4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 5 THR A  68
ASP A 150
HIS A 148
HIS A  40
 None
None
TAM  A 309 (-4.8A)
CD  A 301 ( 3.4A)
 1.16A 1ei6A-3wl4A:
undetectable		 1ei6A-3wl4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		3 / 3 TRP A 224
PHE A 219
TRP A 227
 None
HEZ  A 315 ( 4.4A)
HEZ  A 315 (-3.8A)
 1.19A 1r15C-3wl4A:
undetectable		 1r15C-3wl4A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		3 / 3 TRP A 224
PHE A 219
TRP A 227
 None
HEZ  A 315 ( 4.4A)
HEZ  A 315 (-3.8A)
 1.18A 1r15F-3wl4A:
undetectable		 1r15F-3wl4A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		3 / 3 TRP A 224
PHE A 219
TRP A 227
 None
HEZ  A 315 ( 4.4A)
HEZ  A 315 (-3.8A)
 1.19A 1r15G-3wl4A:
undetectable		 1r15G-3wl4A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		3 / 3 TRP A 224
PHE A 219
TRP A 227
 None
HEZ  A 315 ( 4.4A)
HEZ  A 315 (-3.8A)
 1.18A 1r15H-3wl4A:
undetectable		 1r15H-3wl4A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ILE A 127
TRP A 142
ILE A 187
VAL A 184
ILE A  37
 None
None
HEZ  A 317 ( 4.3A)
HEZ  A 317 (-4.7A)
None
 1.14A 1r5lA-3wl4A:
undetectable		 1r5lA-3wl4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 8 HIS A  40
ARG A  88
ASP A 111
HIS A 148
ASP A 150
 CD  A 301 ( 3.4A)
TAM  A 309 ( 4.3A)
None
TAM  A 309 (-4.8A)
None
 0.38A 2xadA-3wl4A:
20.2		 2xadA-3wl4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 8 HIS A  40
ARG A  88
ASP A 111
HIS A 148
ASP A 150
 CD  A 301 ( 3.4A)
TAM  A 309 ( 4.3A)
None
TAM  A 309 (-4.8A)
None
 0.39A 2xadB-3wl4A:
20.1		 2xadB-3wl4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 8 HIS A  40
ARG A  88
ASP A 111
HIS A 148
ASP A 150
 CD  A 301 ( 3.4A)
TAM  A 309 ( 4.3A)
None
TAM  A 309 (-4.8A)
None
 0.39A 2xadC-3wl4A:
20.2		 2xadC-3wl4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 8 HIS A  40
ARG A  88
ASP A 111
HIS A 148
ASP A 150
 CD  A 301 ( 3.4A)
TAM  A 309 ( 4.3A)
None
TAM  A 309 (-4.8A)
None
 0.38A 2xadD-3wl4A:
20.2		 2xadD-3wl4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		3 / 3 TYR A  64
GLU A 248
ASP A 200
 None
 0.83A 3bxoA-3wl4A:
3.4		 3bxoA-3wl4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 10 VAL A 199
MET A  48
ILE A  52
VAL A  62
VAL A  34
 None
 1.09A 3fhjA-3wl4A:
4.6		 3fhjA-3wl4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 10 VAL A 199
MET A  48
ILE A  52
VAL A  62
VAL A  34
 None
 1.09A 3fhjB-3wl4A:
4.7		 3fhjB-3wl4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 10 VAL A 199
MET A  48
ILE A  52
VAL A  62
VAL A  34
 None
 1.10A 3fhjC-3wl4A:
4.9		 3fhjC-3wl4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 VAL A 199
MET A  48
ILE A  52
VAL A  62
VAL A  34
 None
 1.09A 3fhjD-3wl4A:
4.3		 3fhjD-3wl4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 10 VAL A 199
MET A  48
ILE A  52
VAL A  62
VAL A  34
 None
 1.09A 3fhjE-3wl4A:
4.8		 3fhjE-3wl4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 VAL A 199
MET A  48
ILE A  52
VAL A  62
VAL A  34
 None
 1.09A 3fhjF-3wl4A:
4.8		 3fhjF-3wl4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 THR A  68
ASP A 150
HIS A 148
HIS A  40
 None
None
TAM  A 309 (-4.8A)
CD  A 301 ( 3.4A)
 1.12A 3t01A-3wl4A:
undetectable		 3t01A-3wl4A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 HIS A 148
GLU A  38
ASP A 111
GLU A  91
 TAM  A 309 (-4.8A)
None
None
None
 1.17A 3vywA-3wl4A:
2.9		 3vywA-3wl4A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 SER A  56
LEU A  55
ALA A 211
ASP A  43
GLY A  47
 None
None
None
CD  A 301 ( 2.1A)
None
 1.39A 4j7xA-3wl4A:
4.2		 4j7xA-3wl4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 5 ILE A  35
HIS A 151
TYR A 109
VAL A 120
 None
CD  A 301 ( 3.5A)
None
None
 1.27A 4s0vA-3wl4A:
2.1		 4s0vA-3wl4A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.98A 4w5oA-3wl4A:
2.5		 4w5oA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.88A 4w5qA-3wl4A:
3.1		 4w5qA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.82A 4w5tA-3wl4A:
2.5		 4w5tA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLU A 146
GLY A  47
ALA A  45
GLU A  92
PHE A 230
 None
 1.08A 4xe5A-3wl4A:
undetectable		 4xe5A-3wl4A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.95A 4z4cA-3wl4A:
2.5		 4z4cA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.93A 4z4dA-3wl4A:
2.9		 4z4dA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.88A 4z4eA-3wl4A:
2.9		 4z4eA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.95A 4z4gA-3wl4A:
2.3		 4z4gA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		5 / 12 PHE A  28
VAL A 252
ILE A 187
PHE A 186
ILE A  37
 None
None
HEZ  A 317 ( 4.3A)
None
None
 1.18A 5hkgA-3wl4A:
undetectable		 5hkgA-3wl4A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 5 HIS A 215
ALA A  45
SER A  95
TYR A  64
 None
 1.37A 5yodF-3wl4A:
undetectable		 5yodF-3wl4A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 3wl4 UNCHARACTERIZED
PROTEIN
(Pyrococcus
furiosus) 		4 / 6 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.81A 6cbdA-3wl4A:
2.2		 6cbdA-3wl4A:
14.25