SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		3 / 3 TRP A  44
VAL A  45
PRO A  46
 None
 0.68A 1rg1A-3wlaA:
undetectable		 1rg1A-3wlaA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		3 / 3 TRP A  44
VAL A  45
PRO A  46
 None
 0.68A 1rh0A-3wlaA:
undetectable		 1rh0A-3wlaA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		4 / 7 GLY A  49
TRP A 108
HIS A 279
TYR A 251
 SO4  A 901 ( 3.7A)
None
SO4  A 901 ( 4.4A)
None
 1.19A 1th6A-3wlaA:
undetectable		 1th6A-3wlaA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		4 / 7 GLY A  49
TRP A 108
HIS A 279
TYR A 251
 SO4  A 901 ( 3.7A)
None
SO4  A 901 ( 4.4A)
None
 1.17A 2armA-3wlaA:
undetectable		 2armA-3wlaA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		3 / 3 GLY A 111
ARG A 164
TYR A 184
 None
 0.64A 2opxA-3wlaA:
undetectable		 2opxA-3wlaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		5 / 6 PRO A  79
GLY A 153
GLY A 154
GLY A 158
GLY A  49
 None
None
None
None
SO4  A 901 ( 3.7A)
 0.94A 3bogB-3wlaA:
undetectable
3bogD-3wlaA:
undetectable		 3bogB-3wlaA:
undetectable
3bogD-3wlaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		4 / 8 ASN A 295
TRP A 292
ASN A 285
THR A 286
 None
 0.95A 4d1yA-3wlaA:
undetectable
4d1yB-3wlaA:
3.0		 4d1yA-3wlaA:
19.94
4d1yB-3wlaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		3 / 3 HIS A 279
GLY A  49
ILE A 155
 SO4  A 901 ( 4.4A)
SO4  A 901 ( 3.7A)
None
 0.64A 4k50A-3wlaA:
undetectable		 4k50A-3wlaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		3 / 3 HIS A 279
GLY A 158
ILE A 155
 SO4  A 901 ( 4.4A)
None
None
 0.59A 4k50A-3wlaA:
undetectable		 4k50A-3wlaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		3 / 3 HIS A 279
GLY A 159
ILE A 155
 SO4  A 901 ( 4.4A)
None
None
 0.56A 4k50A-3wlaA:
undetectable		 4k50A-3wlaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		3 / 3 HIS A 279
GLY A  49
ILE A 155
 SO4  A 901 ( 4.4A)
SO4  A 901 ( 3.7A)
None
 0.63A 4k50I-3wlaA:
undetectable		 4k50I-3wlaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		3 / 3 HIS A 279
GLY A 158
ILE A 155
 SO4  A 901 ( 4.4A)
None
None
 0.61A 4k50I-3wlaA:
undetectable		 4k50I-3wlaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		3 / 3 HIS A 279
GLY A 159
ILE A 155
 SO4  A 901 ( 4.4A)
None
None
 0.56A 4k50I-3wlaA:
undetectable		 4k50I-3wlaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		4 / 8 ASP A 327
SER A 274
SER A 259
ARG A 324
 None
 0.80A 4lv9A-3wlaA:
undetectable
4lv9B-3wlaA:
undetectable		 4lv9A-3wlaA:
19.84
4lv9B-3wlaA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		4 / 7 ASP A 327
SER A 274
SER A 259
ARG A 324
 None
 0.79A 4lv9A-3wlaA:
undetectable
4lv9B-3wlaA:
undetectable		 4lv9A-3wlaA:
19.84
4lv9B-3wlaA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		3 / 3 GLY A 215
PRO A 216
GLN A 211
 None
 0.54A 4oltB-3wlaA:
undetectable		 4oltB-3wlaA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		3 / 3 GLY A 215
PRO A 216
GLN A 211
 None
 0.59A 4qwpB-3wlaA:
undetectable		 4qwpB-3wlaA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		4 / 4 GLU A 235
GLY A 234
HIS A 328
ARG A 252
 None
 1.20A 4r82A-3wlaA:
undetectable
4r82B-3wlaA:
undetectable		 4r82A-3wlaA:
20.61
4r82B-3wlaA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		4 / 8 SER A 117
GLY A 102
TYR A 217
GLY A 111
 None
 0.87A 5albL-3wlaA:
undetectable		 5albL-3wlaA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LI8_A_KKKA502_1
(PUTATIVE CYTOCHROME
P450 126)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		5 / 12 THR A  54
PRO A  79
VAL A 227
ALA A 293
ASN A  57
 None
 1.40A 5li8A-3wlaA:
0.0		 5li8A-3wlaA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		4 / 5 LEU A 219
PHE A 262
LEU A 223
TRP A 183
 None
 1.11A 5m10A-3wlaA:
undetectable		 5m10A-3wlaA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		5 / 12 ALA A 113
PRO A 114
ASP A 127
GLY A 126
ASP A 119
 None
 1.25A 5wwsB-3wlaA:
undetectable		 5wwsB-3wlaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		4 / 8 GLY A 154
ILE A 155
ASP A 110
PRO A 107
 None
 0.84A 6ag0A-3wlaA:
undetectable		 6ag0A-3wlaA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		4 / 5 GLY A  49
THR A  50
HIS A 279
SER A 249
 SO4  A 901 ( 3.7A)
SO4  A 901 (-3.8A)
SO4  A 901 ( 4.4A)
None
 1.09A 6jmjA-3wlaA:
undetectable		 6jmjA-3wlaA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE
(Sphingopyxis
sp.
113P3) 		4 / 6 GLY A  49
THR A  50
HIS A 279
SER A 249
 SO4  A 901 ( 3.7A)
SO4  A 901 (-3.8A)
SO4  A 901 ( 4.4A)
None
 1.08A 6jogA-3wlaA:
undetectable		 6jogA-3wlaA:
18.15