SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wlx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		4 / 8 ASN B 137
ASP B 254
GLY B 141
ASP B 274
 None
 0.78A 1bu5B-3wlxB:
undetectable		 1bu5B-3wlxB:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 0.98A 1dhiA-3wlxB:
2.8		 1dhiA-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 0.99A 1dhiB-3wlxB:
undetectable		 1dhiB-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 0.99A 1dhjA-3wlxB:
2.9		 1dhjA-3wlxB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 1.01A 1dhjB-3wlxB:
undetectable		 1dhjB-3wlxB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 1.01A 1draB-3wlxB:
undetectable		 1draB-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 0.97A 1drbA-3wlxB:
2.2		 1drbA-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		6 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.19A 1drbB-3wlxB:
2.5		 1drbB-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 SER B 134
VAL B  78
TYR B  76
GLU B 136
GLY B 167
 None
None
None
PLG  B 401 (-3.5A)
None
 1.34A 1i9jH-3wlxB:
undetectable
1i9jL-3wlxB:
undetectable		 1i9jH-3wlxB:
20.59
1i9jL-3wlxB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
THR B 138
 None
 1.21A 1jolA-3wlxB:
undetectable		 1jolA-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		6 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.10A 1ra2A-3wlxB:
undetectable		 1ra2A-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 0.99A 1ra3A-3wlxB:
2.5		 1ra3A-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		6 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.11A 1ra8A-3wlxB:
2.3		 1ra8A-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		6 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.07A 1rb2A-3wlxB:
undetectable		 1rb2A-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		6 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.10A 1rb2B-3wlxB:
undetectable		 1rb2B-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 0.95A 1rb3B-3wlxB:
undetectable		 1rb3B-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		6 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.18A 1rd7A-3wlxB:
undetectable		 1rd7A-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 1.02A 1rd7B-3wlxB:
2.2		 1rd7B-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
PHE B 171
ILE B 193
THR B 138
 None
 1.08A 1re7A-3wlxB:
2.7		 1re7A-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
 None
 1.20A 1re7B-3wlxB:
2.5		 1re7B-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.16A 1re7B-3wlxB:
2.5		 1re7B-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		6 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.21A 1rx7A-3wlxB:
undetectable		 1rx7A-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 193
GLY B 209
ALA B  51
VAL B 165
ALA B  65
 None
 1.40A 1vq1A-3wlxB:
4.4		 1vq1A-3wlxB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		6 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.07A 2d0kA-3wlxB:
undetectable		 2d0kA-3wlxB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		6 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.10A 2d0kB-3wlxB:
undetectable		 2d0kB-3wlxB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 1.02A 2drcB-3wlxB:
2.4		 2drcB-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 THR B 311
ALA B 256
ARG B 248
GLY B 198
SER B   6
 None
None
None
None
PLG  B 401 (-2.9A)
 1.15A 2f162-3wlxB:
undetectable		 2f162-3wlxB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 THR B 192
ALA B  82
ALA B  61
GLY B  58
THR B  59
 None
None
None
PLG  B 401 (-3.5A)
PLG  B 401 (-3.7A)
 1.18A 2f16H-3wlxB:
undetectable
2f16I-3wlxB:
undetectable		 2f16H-3wlxB:
21.39
2f16I-3wlxB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 THR B 311
ALA B 256
ARG B 248
GLY B 198
SER B   6
 None
None
None
None
PLG  B 401 (-2.9A)
 1.15A 2f16N-3wlxB:
undetectable		 2f16N-3wlxB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 THR B 192
ALA B  82
ALA B  61
GLY B  58
THR B  59
 None
None
None
PLG  B 401 (-3.5A)
PLG  B 401 (-3.7A)
 1.18A 2f16V-3wlxB:
undetectable
2f16W-3wlxB:
undetectable		 2f16V-3wlxB:
21.39
2f16W-3wlxB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		4 / 7 LEU B 206
ALA B 235
GLY B 238
PHE B 191
 None
 0.95A 2wq5A-3wlxB:
undetectable		 2wq5A-3wlxB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 GLY B 200
GLY B 198
ARG B 248
ALA B 237
ASP B 314
 None
 1.17A 3ckkA-3wlxB:
undetectable		 3ckkA-3wlxB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 0.99A 3drcB-3wlxB:
undetectable		 3drcB-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		4 / 4 ILE B 170
PHE B 171
ILE B 193
THR B 138
 None
 1.05A 3ia4A-3wlxB:
2.6		 3ia4A-3wlxB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 THR B 311
ALA B 256
ARG B 248
GLY B 198
SER B   6
 None
None
None
None
PLG  B 401 (-2.9A)
 1.18A 3mg0N-3wlxB:
undetectable		 3mg0N-3wlxB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 10 PRO B 100
ASN B  84
GLY B  79
GLY B  91
ALA B  92
 None
 1.41A 3pp7B-3wlxB:
undetectable		 3pp7B-3wlxB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
THR B 138
 None
 1.19A 3ql0A-3wlxB:
undetectable		 3ql0A-3wlxB:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 1.04A 4dfrB-3wlxB:
undetectable		 4dfrB-3wlxB:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		4 / 4 GLU B  88
ASP B 166
ARG B 308
THR B 192
 None
PLG  B 401 (-2.7A)
PLG  B 401 (-3.3A)
None
 1.47A 4ej1A-3wlxB:
1.6		 4ej1A-3wlxB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		6 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.17A 4fhbA-3wlxB:
undetectable		 4fhbA-3wlxB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 ILE B 170
LEU B 249
PHE B 171
LEU B 242
THR B 138
 None
 1.21A 4i1nA-3wlxB:
2.3		 4i1nA-3wlxB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		4 / 5 TYR B 213
THR B 110
LEU B 144
THR B 185
 None
 1.44A 4mbsB-3wlxB:
undetectable		 4mbsB-3wlxB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 11 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 0.97A 4p66A-3wlxB:
2.7		 4p66A-3wlxB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
PHE B 171
ILE B 193
THR B 138
 None
 1.04A 4ptjA-3wlxB:
2.7		 4ptjA-3wlxB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
THR B 138
 None
 1.19A 4qlgA-3wlxB:
undetectable		 4qlgA-3wlxB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
THR B 138
 None
 1.19A 4rgcA-3wlxB:
2.3		 4rgcA-3wlxB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
LEU B 242
ILE B 193
THR B 138
 None
 0.97A 4x5gB-3wlxB:
2.8		 4x5gB-3wlxB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		6 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.10A 4x5iA-3wlxB:
undetectable		 4x5iA-3wlxB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
PHE B 171
ILE B 193
THR B 138
 None
 1.09A 4x5jA-3wlxB:
undetectable		 4x5jA-3wlxB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 ILE B 170
LEU B 249
PHE B 171
ILE B 193
THR B 138
 None
 1.07A 5e8qA-3wlxB:
2.7		 5e8qA-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		6 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.13A 5eajA-3wlxB:
2.5		 5eajA-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 10 ALA B 256
ALA B 260
VAL B 270
LEU B   4
VAL B 280
 None
 1.27A 5eb5B-3wlxB:
1.0		 5eb5B-3wlxB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		6 / 12 ILE B 170
LEU B 249
PHE B 171
LEU B 242
ILE B 193
THR B 138
 None
 1.15A 5ujxA-3wlxB:
2.8		 5ujxA-3wlxB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 LEU B  66
PRO B 100
GLN B  99
GLY B  96
GLY B  91
 None
 1.09A 5wyqA-3wlxB:
undetectable		 5wyqA-3wlxB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		4 / 5 VAL B 246
LEU B  46
VAL B 208
LEU B  39
 None
 1.02A 6bqgA-3wlxB:
undetectable		 6bqgA-3wlxB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE
(Escherichia
coli) 		5 / 12 LEU B  55
SER B  47
LYS B  49
ILE B 170
ASP B 166
 None
None
None
None
PLG  B 401 (-2.7A)
 1.36A 6bxnA-3wlxB:
3.3		 6bxnA-3wlxB:
22.16