SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wme'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		5 / 12 LEU A 130
PHE A 173
ALA A 178
SER A 180
LEU A 184
 None
 1.14A 1fe2A-3wmeA:
undetectable		 1fe2A-3wmeA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		5 / 12 LEU A 533
ALA A 598
ALA A 594
VAL A 578
TYR A 544
 None
 1.21A 1kt4A-3wmeA:
undetectable		 1kt4A-3wmeA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		4 / 7 VAL A 567
VAL A 554
ASP A 551
ILE A 555
 None
 0.90A 1p7rA-3wmeA:
undetectable		 1p7rA-3wmeA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		4 / 8 ASP A 227
GLY A 410
GLY A 411
LEU A 413
 None
 0.54A 1qzzA-3wmeA:
undetectable		 1qzzA-3wmeA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		3 / 3 GLY A 635
ASP A 634
ASN A 470
 None
 0.62A 1vq1A-3wmeA:
2.6		 1vq1A-3wmeA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		5 / 12 PHE A 258
PHE A 138
ALA A 133
GLY A 166
GLY A 171
 None
 1.01A 2igtA-3wmeA:
2.1		 2igtA-3wmeA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		5 / 12 PHE A 258
PHE A 138
ALA A 133
GLY A 166
GLY A 171
 None
 1.01A 2igtB-3wmeA:
undetectable		 2igtB-3wmeA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		3 / 3 ARG A 424
ARG A 493
PRO A 511
 None
 1.06A 2wljA-3wmeA:
4.0		 2wljA-3wmeA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		5 / 9 PHE A 450
VAL A 448
GLY A 463
ARG A 462
GLY A 502
 None
 1.50A 3csjB-3wmeA:
undetectable		 3csjB-3wmeA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		5 / 12 ILE A 443
ALA A 512
LEU A 490
GLN A 489
ILE A 464
 None
 1.30A 3ia4B-3wmeA:
undetectable		 3ia4B-3wmeA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		4 / 8 ARG A 181
SER A 236
ASP A 402
TYR A 233
 None
 1.25A 3jq7B-3wmeA:
undetectable		 3jq7B-3wmeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		4 / 6 ARG A 181
SER A 236
ASP A 402
TYR A 233
 None
 1.26A 3jqaA-3wmeA:
undetectable		 3jqaA-3wmeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		4 / 6 ARG A 181
SER A 236
ASP A 402
TYR A 233
 None
 1.27A 3jqaB-3wmeA:
undetectable		 3jqaB-3wmeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		4 / 6 ARG A 181
SER A 236
ASP A 402
TYR A 233
 None
 1.27A 3jqaC-3wmeA:
undetectable		 3jqaC-3wmeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		4 / 6 ARG A 181
SER A 236
ASP A 402
TYR A 233
 None
 1.26A 3jqaD-3wmeA:
undetectable		 3jqaD-3wmeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		5 / 12 LEU A 196
PHE A 414
ILE A 109
ALA A 113
SER A 116
 None
 1.05A 3kk6A-3wmeA:
undetectable		 3kk6A-3wmeA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		5 / 12 LEU A 558
ALA A 561
GLU A 560
LEU A 600
ILE A 538
 None
 1.31A 3olsB-3wmeA:
undetectable		 3olsB-3wmeA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		5 / 12 VAL A 639
GLY A 483
VAL A 474
LEU A 466
THR A 467
 None
 0.87A 4m2vA-3wmeA:
undetectable		 4m2vA-3wmeA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		4 / 6 PHE A 243
LEU A 388
PRO A 136
ARG A 181
 None
 1.19A 4yv5B-3wmeA:
undetectable		 4yv5B-3wmeA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		4 / 6 PHE A 243
LEU A 388
PRO A 136
ARG A 181
 None
 1.15A 4yv5A-3wmeA:
undetectable		 4yv5A-3wmeA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		3 / 3 ASP A 402
ASN A 244
GLN A 395
 None
 0.80A 5k7uA-3wmeA:
undetectable		 5k7uA-3wmeA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		4 / 5 TYR A 163
LEU A 380
GLY A 143
PHE A 142
 None
 0.89A 5kmdC-3wmeA:
3.8
5kmdD-3wmeA:
4.2		 5kmdC-3wmeA:
19.32
5kmdD-3wmeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		5 / 12 LEU A 413
ILE A 231
GLY A 406
THR A 102
LEU A 112
 None
 1.16A 5nfjB-3wmeA:
undetectable		 5nfjB-3wmeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		5 / 12 LEU A 413
ILE A 231
GLY A 406
THR A 102
LEU A 112
 None
 1.15A 5nfjC-3wmeA:
undetectable		 5nfjC-3wmeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		4 / 8 LEU A 533
ALA A 598
VAL A 578
TYR A 544
 None
 0.94A 5nu7A-3wmeA:
undetectable		 5nu7A-3wmeA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		4 / 5 ALA A 584
VAL A 578
LYS A 590
ILE A 538
 None
 1.02A 5of1B-3wmeA:
undetectable		 5of1B-3wmeA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1
(Cyanidioschyzon
merolae) 		5 / 12 LEU A 466
GLY A 483
GLY A 660
PHE A 450
ILE A 641
 None
 1.01A 6ecxA-3wmeA:
undetectable		 6ecxA-3wmeA:
22.90