SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wmr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		4 / 8 GLY A  39
TYR A 211
SER A 110
HIS A 277
 None
 0.88A 1ax9A-3wmrA:
12.9		 1ax9A-3wmrA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		4 / 8 LEU A  86
VAL A 210
GLY A  41
GLU A  90
 None
 0.95A 1jlfA-3wmrA:
undetectable
1jlfB-3wmrA:
undetectable		 1jlfA-3wmrA:
21.65
1jlfB-3wmrA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		4 / 8 GLY A  39
TYR A 211
SER A 110
HIS A 277
 None
 0.94A 1maaD-3wmrA:
13.3		 1maaD-3wmrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		5 / 8 GLY A  38
GLY A 112
GLY A 113
MET A 114
LEU A 115
 None
 1.17A 1qzzA-3wmrA:
2.2		 1qzzA-3wmrA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		5 / 10 GLY A  38
GLY A  39
TYR A 211
SER A 110
HIS A 277
 None
 1.07A 1w76B-3wmrA:
12.2		 1w76B-3wmrA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		5 / 12 THR A  43
GLY A  69
GLY A  70
ASP A 207
ASP A  45
 None
 1.21A 1wg8B-3wmrA:
2.7		 1wg8B-3wmrA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		4 / 7 GLY A  39
TYR A 211
SER A 110
HIS A 277
 None
 0.93A 2ackA-3wmrA:
13.1		 2ackA-3wmrA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		3 / 3 LEU A 153
PRO A 154
ARG A 180
 None
 0.46A 2qd4B-3wmrA:
2.8		 2qd4B-3wmrA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		3 / 3 LEU A 153
PRO A 154
ARG A 180
 None
 0.50A 2qd5A-3wmrA:
3.3		 2qd5A-3wmrA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		3 / 3 VAL A 290
ASP A 293
GLU A 270
 None
 0.73A 2qeuA-3wmrA:
undetectable		 2qeuA-3wmrA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		3 / 3 VAL A 290
ASP A 293
GLU A 270
 None
 0.71A 2qeuC-3wmrA:
undetectable		 2qeuC-3wmrA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		4 / 7 GLN A 109
GLY A  38
HIS A 280
HIS A 277
 None
 1.22A 3ai8A-3wmrA:
undetectable		 3ai8A-3wmrA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		4 / 7 TRP A 111
VAL A 210
LEU A  86
TRP A 229
 None
None
None
P4G  A 402 (-4.4A)
 1.10A 3arrA-3wmrA:
undetectable		 3arrA-3wmrA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		5 / 10 LEU A  47
SER A  42
TYR A 211
GLY A 112
GLY A 108
 None
 1.33A 3ls4H-3wmrA:
undetectable		 3ls4H-3wmrA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		4 / 8 ASN A 134
GLU A 282
LEU A 245
PHE A 287
 None
 1.04A 3rqwC-3wmrA:
undetectable
3rqwD-3wmrA:
undetectable		 3rqwC-3wmrA:
19.25
3rqwD-3wmrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		4 / 8 GLU A 282
LEU A 245
PHE A 287
ASN A 134
 None
 1.05A 3rqwF-3wmrA:
undetectable
3rqwJ-3wmrA:
undetectable		 3rqwF-3wmrA:
19.25
3rqwJ-3wmrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		5 / 12 HIS A 277
ASP A 250
GLY A  38
SER A 110
ALA A 133
 None
 1.10A 3sueB-3wmrA:
undetectable		 3sueB-3wmrA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		5 / 12 HIS A 277
ASP A 250
GLY A  38
SER A 110
ALA A 133
 None
 1.19A 3sueD-3wmrA:
undetectable		 3sueD-3wmrA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		5 / 12 ASP A 250
LEU A  36
GLY A  38
SER A 110
ALA A 133
 None
 1.05A 3sufA-3wmrA:
undetectable		 3sufA-3wmrA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		5 / 11 HIS A 277
ASP A 250
GLY A  38
SER A 110
ALA A 133
 None
 1.18A 3sufC-3wmrA:
undetectable		 3sufC-3wmrA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		5 / 11 GLY A 108
SER A 117
ALA A 120
ILE A 238
MET A 291
 None
 1.15A 4xumB-3wmrA:
undetectable		 4xumB-3wmrA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		5 / 12 GLY A  39
GLY A 247
ILE A 246
GLY A 108
GLY A 112
 None
 0.92A 5koxA-3wmrA:
undetectable		 5koxA-3wmrA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		5 / 12 LEU A 245
VAL A 187
PHE A 287
MET A  50
LEU A  47
 None
 1.44A 5uc3B-3wmrA:
undetectable		 5uc3B-3wmrA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3wmr PROLINE
IMINOPEPTIDASE
(Streptomyces
halstedii) 		4 / 6 PRO A 217
GLY A 216
THR A 212
ASN A 215
 None
 0.66A 5xxiA-3wmrA:
undetectable		 5xxiA-3wmrA:
20.44