SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wmt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 7 GLY A 414
PRO A 451
ASP A 286
SER A 422
 None
 0.99A 1gxsA-3wmtA:
5.7
1gxsB-3wmtA:
undetectable		 1gxsA-3wmtA:
18.87
1gxsB-3wmtA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 8 LEU A  94
VAL A 146
GLY A 147
LEU A 185
 None
 0.97A 1jlbA-3wmtA:
undetectable		 1jlbA-3wmtA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		5 / 12 GLY A 124
GLY A 125
SER A 203
LEU A 126
HIS A 457
 None
 0.92A 1mx1D-3wmtA:
10.8		 1mx1D-3wmtA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		5 / 12 GLY A 124
GLY A 125
SER A 203
LEU A 126
HIS A 457
 None
 0.85A 1ya4A-3wmtA:
11.8		 1ya4A-3wmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		5 / 12 GLY A 124
GLY A 125
SER A 203
LEU A 126
HIS A 457
 None
 0.79A 1ya4B-3wmtA:
6.5		 1ya4B-3wmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		5 / 12 GLY A 124
GLY A 125
SER A 203
LEU A 126
HIS A 457
 None
 0.80A 1ya4C-3wmtA:
11.3		 1ya4C-3wmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 4 GLY A 124
SER A 203
ILE A 419
HIS A 457
 None
 1.06A 1yajJ-3wmtA:
undetectable		 1yajJ-3wmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 4 GLY A 125
SER A 203
ILE A 419
HIS A 457
 None
 1.00A 1yajJ-3wmtA:
undetectable		 1yajJ-3wmtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 7 GLY A 125
TYR A 356
SER A 203
HIS A 457
 None
 1.08A 2ackA-3wmtA:
12.9		 2ackA-3wmtA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		5 / 12 TYR A 199
THR A 121
GLY A 122
GLY A 124
THR A 204
 None
 1.21A 2akeA-3wmtA:
undetectable		 2akeA-3wmtA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		5 / 12 TYR A 199
THR A 121
GLY A 122
GLY A 124
THR A 204
 None
 1.21A 2azxA-3wmtA:
undetectable		 2azxA-3wmtA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 8 PHE A 331
ALA A 323
ARG A 335
ASP A 286
 None
 0.84A 2bxkA-3wmtA:
undetectable		 2bxkA-3wmtA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		5 / 12 GLY A 205
GLY A 201
ALA A 227
GLN A 469
ASP A 134
 None
 1.05A 2c49A-3wmtA:
3.2		 2c49A-3wmtA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 6 ALA A 381
TYR A 361
ILE A 383
ILE A 233
 None
 1.26A 2dcfA-3wmtA:
undetectable		 2dcfA-3wmtA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		3 / 3 TYR A 194
GLY A 116
PHE A 118
 None
 0.61A 2m2pB-3wmtA:
undetectable		 2m2pB-3wmtA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		5 / 10 ALA A 459
ASN A 460
ALA A 461
GLU A 416
ALA A 456
 None
 1.20A 2r2vC-3wmtA:
undetectable
2r2vF-3wmtA:
undetectable
2r2vG-3wmtA:
undetectable		 2r2vC-3wmtA:
5.25
2r2vF-3wmtA:
5.25
2r2vG-3wmtA:
5.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 8 ALA A 461
ALA A 459
SER A 465
ALA A 466
 None
 0.86A 2vh3B-3wmtA:
undetectable		 2vh3B-3wmtA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		5 / 9 GLY A 311
ILE A 292
VAL A 317
VAL A 255
GLN A 259
 None
 1.12A 3fi0H-3wmtA:
undetectable		 3fi0H-3wmtA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G59_A_ACTA306_0
(FMN
ADENYLYLTRANSFERASE)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 5 SER A 347
MET A 336
ILE A 419
TRP A 238
 None
 1.42A 3g59A-3wmtA:
0.2		 3g59A-3wmtA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		5 / 12 GLY A 122
GLY A 151
GLY A 128
LEU A 126
ALA A 174
 None
NAG  A 602 (-4.0A)
None
None
None
 0.99A 3kkzB-3wmtA:
2.1		 3kkzB-3wmtA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 7 GLY A 124
GLY A 125
SER A 203
HIS A 457
 None
 0.70A 3o9mA-3wmtA:
12.3		 3o9mA-3wmtA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 6 GLY A 124
GLY A 125
SER A 203
HIS A 457
 None
 0.75A 3o9mB-3wmtA:
12.4		 3o9mB-3wmtA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		5 / 12 GLY A 182
THR A 145
LEU A 119
VAL A  50
GLY A 178
 None
 1.07A 3sglA-3wmtA:
undetectable		 3sglA-3wmtA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 5 PHE A 220
TYR A 194
LEU A 410
ARG A 117
 None
 1.24A 3sudD-3wmtA:
0.6		 3sudD-3wmtA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		5 / 12 PHE A 170
PHE A 160
GLY A 127
GLY A 151
GLY A 154
 None
None
None
NAG  A 602 (-4.0A)
None
 1.18A 3tegA-3wmtA:
undetectable		 3tegA-3wmtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 8 TRP A 360
VAL A 365
ILE A 383
ILE A 233
 None
 1.01A 4afgD-3wmtA:
undetectable
4afgE-3wmtA:
undetectable		 4afgD-3wmtA:
16.67
4afgE-3wmtA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		3 / 3 GLU A 257
TYR A 345
SER A 346
 None
 0.98A 4at0A-3wmtA:
undetectable		 4at0A-3wmtA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		5 / 12 PHE A 232
PHE A 170
GLN A 208
LEU A 235
ILE A 419
 None
 1.12A 4g1bA-3wmtA:
undetectable		 4g1bA-3wmtA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 8 VAL A 181
ASN A  52
ILE A  48
MET A 106
 None
 1.10A 4iilA-3wmtA:
undetectable		 4iilA-3wmtA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		4 / 6 VAL A 130
SER A 120
ALA A 139
PHE A  87
 None
 1.18A 4nedA-3wmtA:
undetectable		 4nedA-3wmtA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		3 / 3 TYR A 512
GLY A 463
PRO A 464
 None
 0.69A 4qwpA-3wmtA:
0.3		 4qwpA-3wmtA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		3 / 3 ASP A 380
ASN A 385
PHE A 232
 None
NAG  A 603 (-3.7A)
None
 0.69A 5dsgB-3wmtA:
undetectable		 5dsgB-3wmtA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3wmt PROBABLE FERULOYL
ESTERASE B-1
(Aspergillus
oryzae) 		3 / 3 ASP A 169
ASN A 163
PHE A 105
 None
None
NAG  A 602 (-4.7A)
 0.91A 5jglB-3wmtA:
undetectable		 5jglB-3wmtA:
20.36