SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wmx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		6 / 12 ALA A  78
ALA A  77
ASN A  14
LEU A  80
ALA A  79
LEU A  21
 NAD  A 401 (-3.5A)
NAD  A 401 (-3.4A)
None
THR  A 402 (-3.6A)
None
None
 1.49A 2aclA-3wmxA:
undetectable
2aclE-3wmxA:
undetectable		 2aclA-3wmxA:
22.29
2aclE-3wmxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		5 / 12 LEU A 301
ALA A 254
ILE A 257
ILE A 192
ALA A 189
 None
 1.04A 2bxcA-3wmxA:
undetectable		 2bxcA-3wmxA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		3 / 3 PRO A 250
GLU A 269
TYR A 268
 None
 0.73A 2zmbA-3wmxA:
undetectable		 2zmbA-3wmxA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		5 / 12 ILE A 192
ILE A 257
VAL A 261
GLY A 263
ARG A 267
 None
 1.15A 3em0B-3wmxA:
undetectable		 3em0B-3wmxA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		4 / 5 ILE A 146
PRO A 140
SER A  81
GLY A 145
 None
None
THR  A 402 (-2.8A)
None
 1.08A 3tkdB-3wmxA:
undetectable		 3tkdB-3wmxA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		4 / 5 ILE A 146
PRO A 140
SER A  81
GLY A 145
 None
None
THR  A 402 (-2.8A)
None
 1.07A 3tkdA-3wmxA:
undetectable		 3tkdA-3wmxA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		4 / 7 ASN A 242
GLN A 134
GLU A 237
ARG A 156
 None
 1.33A 4mv7A-3wmxA:
4.5		 4mv7A-3wmxA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		4 / 7 PRO A 281
PHE A 123
TRP A 280
TYR A 144
 None
None
None
NAD  A 401 ( 4.4A)
 1.44A 4v2zA-3wmxA:
undetectable		 4v2zA-3wmxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		4 / 7 PRO A 281
PHE A 123
TRP A 280
TYR A 144
 None
None
None
NAD  A 401 ( 4.4A)
 1.50A 5amhA-3wmxA:
undetectable		 5amhA-3wmxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		4 / 7 PRO A 281
PHE A 123
TRP A 280
TYR A 144
 None
None
None
NAD  A 401 ( 4.4A)
 1.48A 5amiA-3wmxA:
undetectable		 5amiA-3wmxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		4 / 8 PRO A 281
PHE A 123
TRP A 280
TYR A 144
 None
None
None
NAD  A 401 ( 4.4A)
 1.41A 5amiB-3wmxA:
undetectable		 5amiB-3wmxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		4 / 7 PRO A 281
PHE A 123
TRP A 280
TYR A 144
 None
None
None
NAD  A 401 ( 4.4A)
 1.46A 5amjA-3wmxA:
undetectable		 5amjA-3wmxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		4 / 8 PRO A 281
PHE A 123
TRP A 280
TYR A 144
 None
None
None
NAD  A 401 ( 4.4A)
 1.31A 5amkA-3wmxA:
undetectable		 5amkA-3wmxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		4 / 6 ILE A  70
TYR A  74
VAL A  73
SER A  37
 None
 0.83A 5jwaH-3wmxA:
4.6		 5jwaH-3wmxA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		4 / 7 PRO A 281
PHE A 123
TRP A 280
TYR A 144
 None
None
None
NAD  A 401 ( 4.4A)
 1.44A 5oh1B-3wmxA:
undetectable		 5oh1B-3wmxA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		4 / 7 PRO A 281
PHE A 123
TRP A 280
TYR A 144
 None
None
None
NAD  A 401 ( 4.4A)
 1.49A 5oh3A-3wmxA:
undetectable		 5oh3A-3wmxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_B_9V2B202_0
(CEREBLON ISOFORM 4)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		4 / 7 PRO A 281
PHE A 123
TRP A 280
TYR A 144
 None
None
None
NAD  A 401 ( 4.4A)
 1.40A 5oh3B-3wmxA:
undetectable		 5oh3B-3wmxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		3 / 3 ASP A 165
ARG A 113
ASP A 233
 None
 0.83A 5zvgA-3wmxA:
5.6		 5zvgA-3wmxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3wmx NAD DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Cupriavidus
necator) 		3 / 3 ASP A 165
ARG A 113
ASP A 233
 None
 0.86A 5zvgB-3wmxA:
5.7		 5zvgB-3wmxA:
22.86