SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wnb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A
(Methanosarcina
mazei) 		4 / 7 MET A  32
SER A  56
ALA A  60
ILE A  63
 None
 0.94A 1fxhA-3wnbA:
undetectable
1fxhB-3wnbA:
undetectable		 1fxhA-3wnbA:
23.28
1fxhB-3wnbA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A
(Methanosarcina
mazei) 		5 / 11 ASN A   3
VAL A 193
ARG A 249
THR A  59
ILE A  30
 None
 1.37A 2f9wA-3wnbA:
2.4
2f9wB-3wnbA:
undetectable		 2f9wA-3wnbA:
25.79
2f9wB-3wnbA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A
(Methanosarcina
mazei) 		4 / 7 LEU A 334
LEU A 333
ARG A 249
TYR A 263
 None
 1.20A 2hc4A-3wnbA:
undetectable		 2hc4A-3wnbA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A
(Methanosarcina
mazei) 		4 / 6 ILE A 253
THR A 205
VAL A 189
SER A 199
 None
 1.10A 4iaqA-3wnbA:
undetectable		 4iaqA-3wnbA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A
(Methanosarcina
mazei) 		4 / 5 SER A 270
LYS A 271
LEU A  89
ASP A  88
 None
 1.34A 4ifxA-3wnbA:
undetectable		 4ifxA-3wnbA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A
(Methanosarcina
mazei) 		5 / 12 ALA A 325
THR A 205
ILE A 214
LEU A 239
ILE A 253
 None
 1.09A 4kjkA-3wnbA:
undetectable		 4kjkA-3wnbA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A
(Methanosarcina
mazei) 		4 / 6 THR A 268
LEU A  89
ASP A  88
LEU A 333
 None
 1.05A 4wozA-3wnbA:
undetectable
4wozB-3wnbA:
undetectable		 4wozA-3wnbA:
23.21
4wozB-3wnbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A
(Methanosarcina
mazei) 		4 / 5 LEU A  89
ASP A  88
LEU A 333
THR A 268
 None
 1.06A 4wozF-3wnbA:
undetectable
4wozH-3wnbA:
1.9		 4wozF-3wnbA:
23.21
4wozH-3wnbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A
(Methanosarcina
mazei) 		4 / 7 SER A 327
SER A 254
PHE A 176
GLU A 257
 None
 1.33A 4xzkA-3wnbA:
undetectable		 4xzkA-3wnbA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A
(Methanosarcina
mazei) 		5 / 10 ARG A 342
PHE A 343
LEU A  61
ILE A  58
SER A  56
 None
 1.35A 4z69I-3wnbA:
undetectable		 4z69I-3wnbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A
(Methanosarcina
mazei) 		4 / 7 LEU A 113
THR A 100
LEU A  99
THR A  80
 None
 0.92A 4z90A-3wnbA:
undetectable
4z90B-3wnbA:
undetectable
4z90C-3wnbA:
undetectable
4z90D-3wnbA:
undetectable
4z90E-3wnbA:
undetectable		 4z90A-3wnbA:
19.18
4z90B-3wnbA:
19.18
4z90C-3wnbA:
19.18
4z90D-3wnbA:
19.18
4z90E-3wnbA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A
(Methanosarcina
mazei) 		4 / 8 ALA A 335
ILE A  85
ALA A  86
LEU A  89
 None
 0.83A 5te8B-3wnbA:
undetectable		 5te8B-3wnbA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A
(Methanosarcina
mazei) 		5 / 12 LEU A 318
LEU A 334
ALA A 344
LEU A 316
ARG A 294
 None
 0.93A 6b0cD-3wnbA:
undetectable		 6b0cD-3wnbA:
13.20