SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wnw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_A_VDYA1002_1 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	4 / 4	ILE A 145 LEU A 148 VAL A 152 ALA A 160	None	0.80A	1mz9A-3wnwA: undetectable	1mz9A-3wnwA: 13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_A_VDYA1002_3 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	4 / 5	ILE A 145 LEU A 148 VAL A 152 ALA A 160	None	0.79A	1mz9C-3wnwA: undetectable	1mz9C-3wnwA: 13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B9L_A_AZZA1009_1 (SERUM ALBUMIN)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	4 / 8	TYR A 137 GLU A 140 SER A 144 GLN A 141	None None None MG A 201 (-4.1A)	1.22A	3b9lA-3wnwA: undetectable	3b9lA-3wnwA: 16.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3F33_A_PFLA2001_1 (FERRITIN LIGHT CHAIN)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	4 / 6	LEU A 28 SER A 31 TYR A 32 LEU A 35	None	0.16A	3f33A-3wnwA: 27.7	3f33A-3wnwA: 48.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LTW_A_STRA301_1 (ANCESTRAL STEROID RECEPTOR 2)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	5 / 12	LEU A 114 LEU A 117 LEU A 120 ALA A 121 LEU A 72	None	0.96A	4ltwA-3wnwA: undetectable	4ltwA-3wnwA: 21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MI4_C_SPMC201_1 (SPERMIDINE N1-ACETYLTRANSFERASE)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	4 / 7	TYR A 34 GLU A 147 GLU A 107 GLU A 140	None	1.08A	4mi4A-3wnwA: undetectable 4mi4C-3wnwA: undetectable	4mi4A-3wnwA: 21.30 4mi4C-3wnwA: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_A_377A401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	4 / 5	GLU A 107 GLU A 147 TYR A 54 TYR A 34	None	1.34A	4twdA-3wnwA: 3.7 4twdE-3wnwA: 3.6	4twdA-3wnwA: 19.05 4twdE-3wnwA: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_A_377A401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	4 / 5	GLU A 147 GLU A 107 TYR A 34 TYR A 54	None	1.27A	4twdA-3wnwA: 3.7 4twdE-3wnwA: 3.6	4twdA-3wnwA: 19.05 4twdE-3wnwA: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_B_377B401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	4 / 5	TYR A 34 GLU A 107 GLU A 147 TYR A 54	None	1.41A	4twdA-3wnwA: 3.7 4twdB-3wnwA: 3.6	4twdA-3wnwA: 19.05 4twdB-3wnwA: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_B_377B401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	4 / 5	TYR A 54 GLU A 147 GLU A 107 TYR A 34	None	1.29A	4twdA-3wnwA: 3.7 4twdB-3wnwA: 3.6	4twdA-3wnwA: 19.05 4twdB-3wnwA: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_H_377H401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	4 / 6	TYR A 34 GLU A 107 GLU A 147 TYR A 54	None	1.38A	4twdG-3wnwA: 1.2 4twdH-3wnwA: undetectable	4twdG-3wnwA: 19.05 4twdH-3wnwA: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_H_377H401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	4 / 6	TYR A 54 GLU A 147 GLU A 107 TYR A 34	None	1.29A	4twdG-3wnwA: 1.2 4twdH-3wnwA: undetectable	4twdG-3wnwA: 19.05 4twdH-3wnwA: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_H_377H402_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	4 / 5	TYR A 34 GLU A 107 GLU A 147 TYR A 54	None	1.35A	4twdH-3wnwA: undetectable 4twdI-3wnwA: undetectable	4twdH-3wnwA: 19.05 4twdI-3wnwA: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_H_377H402_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3wnw	FERRITIN HEAVY CHAIN (Mus musculus)	4 / 5	TYR A 54 GLU A 147 GLU A 107 TYR A 34	None	1.33A	4twdH-3wnwA: undetectable 4twdI-3wnwA: undetectable	4twdH-3wnwA: 19.05 4twdI-3wnwA: 19.05

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MZ9_A_VDYA1002_1","CARTILAGE OLIGOMERIC MATRIX PROTEIN","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",4,"ILE A 145;LEU A 148;VAL A 152;ALA A 160","None","0.80A","1mz9A-3wnwA:undetectable","1mz9A-3wnwA:13.50"],["1MZ9_A_VDYA1002_3","CARTILAGE OLIGOMERIC MATRIX PROTEIN;CARTILAGE OLIGOMERIC MATRIX PROTEIN","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",4,"ILE A 145;LEU A 148;VAL A 152;ALA A 160","None","0.79A","1mz9C-3wnwA:undetectable","1mz9C-3wnwA:13.50"],["3B9L_A_AZZA1009_1","SERUM ALBUMIN","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",4,"TYR A 137;GLU A 140;SER A 144;GLN A 141","None;None;None; MG A 201 (-4.1A)","1.22A","3b9lA-3wnwA:undetectable","3b9lA-3wnwA:16.01"],["3F33_A_PFLA2001_1","FERRITIN LIGHT CHAIN","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",4,"LEU A  28;SER A  31;TYR A  32;LEU A  35","None","0.16A","3f33A-3wnwA:27.7","3f33A-3wnwA:48.47"],["4LTW_A_STRA301_1","ANCESTRAL STEROID RECEPTOR 2","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",5,"LEU A 114;LEU A 117;LEU A 120;ALA A 121;LEU A  72","None","0.96A","4ltwA-3wnwA:undetectable","4ltwA-3wnwA:21.09"],["4MI4_C_SPMC201_1","SPERMIDINE N1-ACETYLTRANSFERASE;SPERMIDINE N1-ACETYLTRANSFERASE","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",4,"TYR A  34;GLU A 147;GLU A 107;GLU A 140","None","1.08A","4mi4A-3wnwA:undetectable;4mi4C-3wnwA:undetectable","4mi4A-3wnwA:21.30;4mi4C-3wnwA:21.30"],["4TWD_A_377A401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",4,"GLU A 107;GLU A 147;TYR A  54;TYR A  34","None","1.34A","4twdA-3wnwA:3.7;4twdE-3wnwA:3.6","4twdA-3wnwA:19.05;4twdE-3wnwA:19.05"],["4TWD_A_377A401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",4,"GLU A 147;GLU A 107;TYR A  34;TYR A  54","None","1.27A","4twdA-3wnwA:3.7;4twdE-3wnwA:3.6","4twdA-3wnwA:19.05;4twdE-3wnwA:19.05"],["4TWD_B_377B401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",4,"TYR A  34;GLU A 107;GLU A 147;TYR A  54","None","1.41A","4twdA-3wnwA:3.7;4twdB-3wnwA:3.6","4twdA-3wnwA:19.05;4twdB-3wnwA:19.05"],["4TWD_B_377B401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",4,"TYR A  54;GLU A 147;GLU A 107;TYR A  34","None","1.29A","4twdA-3wnwA:3.7;4twdB-3wnwA:3.6","4twdA-3wnwA:19.05;4twdB-3wnwA:19.05"],["4TWD_H_377H401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",4,"TYR A  34;GLU A 107;GLU A 147;TYR A  54","None","1.38A","4twdG-3wnwA:1.2;4twdH-3wnwA:undetectable","4twdG-3wnwA:19.05;4twdH-3wnwA:19.05"],["4TWD_H_377H401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",4,"TYR A  54;GLU A 147;GLU A 107;TYR A  34","None","1.29A","4twdG-3wnwA:1.2;4twdH-3wnwA:undetectable","4twdG-3wnwA:19.05;4twdH-3wnwA:19.05"],["4TWD_H_377H402_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",4,"TYR A  34;GLU A 107;GLU A 147;TYR A  54","None","1.35A","4twdH-3wnwA:undetectable;4twdI-3wnwA:undetectable","4twdH-3wnwA:19.05;4twdI-3wnwA:19.05"],["4TWD_H_377H402_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3wnw","FERRITIN HEAVY CHAIN","Mus musculus",4,"TYR A  54;GLU A 147;GLU A 107;TYR A  34","None","1.33A","4twdH-3wnwA:undetectable;4twdI-3wnwA:undetectable","4twdH-3wnwA:19.05;4twdI-3wnwA:19.05"]]