SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wo0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		5 / 12 PHE A 384
LEU A 379
ALA A 462
LEU A 397
TYR A 468
 None
 1.06A 1cbsA-3wo0A:
undetectable		 1cbsA-3wo0A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		4 / 7 GLU A 319
LYS A 296
PRO A 320
ALA A 293
 None
 1.41A 2ejgB-3wo0A:
1.6		 2ejgB-3wo0A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		5 / 12 PHE A 384
LEU A 379
ALA A 462
LEU A 397
TYR A 468
 None
 1.03A 2fr3A-3wo0A:
undetectable		 2fr3A-3wo0A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		3 / 3 ASP A 450
THR A 266
PRO A 267
 None
 0.57A 2pynB-3wo0A:
undetectable		 2pynB-3wo0A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		3 / 3 ASP A 450
THR A 266
PRO A 267
 None
 0.56A 2q64B-3wo0A:
undetectable		 2q64B-3wo0A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		3 / 3 ASP A 450
THR A 266
PRO A 267
 None
 0.57A 2qakB-3wo0A:
undetectable		 2qakB-3wo0A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		3 / 3 PHE A 329
ASN A 107
PHE A  20
 None
 0.95A 2zbuD-3wo0A:
3.0		 2zbuD-3wo0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		5 / 11 LEU A 110
ALA A  39
ALA A  77
VAL A 217
LEU A 182
 None
 1.25A 3bszE-3wo0A:
undetectable		 3bszE-3wo0A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLH_A_T27A555_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		5 / 12 LEU A 182
VAL A 188
TYR A 207
PRO A 222
TYR A 181
 None
ADP  A 501 (-4.8A)
None
None
None
 1.37A 3qlhA-3wo0A:
1.4		 3qlhA-3wo0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		3 / 3 ASP A 450
THR A 266
PRO A 267
 None
 0.51A 3tkgD-3wo0A:
undetectable		 3tkgD-3wo0A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		4 / 7 GLU A 319
MET A 315
ARG A 142
ILE A 312
 None
 1.50A 4cx7C-3wo0A:
undetectable
4cx7D-3wo0A:
undetectable		 4cx7C-3wo0A:
21.54
4cx7D-3wo0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		3 / 3 GLU A 220
ARG A 157
GLN A 130
 None
 0.90A 4rtbA-3wo0A:
undetectable		 4rtbA-3wo0A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		5 / 12 ALA A 327
THR A 308
LEU A 303
PRO A 114
ALA A 116
 None
 1.10A 4ypmA-3wo0A:
undetectable		 4ypmA-3wo0A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		4 / 8 PRO A  35
PHE A  33
SER A  32
TYR A  21
 None
 1.22A 5amiB-3wo0A:
undetectable		 5amiB-3wo0A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 3wo0 ALANINE-ANTICAPSIN
LIGASE BACD
(Bacillus
subtilis) 		4 / 8 ALA A 135
GLY A 302
LEU A 303
ALA A 127
 None
 0.79A 6mdqA-3wo0A:
undetectable		 6mdqA-3wo0A:
11.32