SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wo4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3wo4 INTERLEUKIN-18
RECEPTOR 1
INTERLEUKIN-18
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens) 		4 / 6 LEU C 254
LEU B 218
SER B 238
SER B 279
 None
None
NAG  B 909 ( 3.4A)
NAG  B 909 ( 3.7A)
 1.02A 1tz8C-3wo4C:
3.0
1tz8D-3wo4C:
undetectable		 1tz8C-3wo4C:
15.70
1tz8D-3wo4C:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3wo4 INTERLEUKIN-18
RECEPTOR 1
(Homo
sapiens) 		5 / 12 LEU B  83
LEU B  68
ASN B  91
GLY B  94
ARG B  75
 None
None
NAG  B 901 (-1.9A)
None
NAG  B 901 ( 4.1A)
 0.97A 2vmyA-3wo4B:
undetectable		 2vmyA-3wo4B:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3wo4 INTERLEUKIN-18
RECEPTOR 1
(Homo
sapiens) 		4 / 8 ASN B 165
SER B 153
TYR B 155
ASN B 150
 None
None
None
NAG  B 903 (-1.9A)
 1.05A 2wekA-3wo4B:
undetectable		 2wekA-3wo4B:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3wo4 INTERLEUKIN-18
RECEPTOR 1
(Homo
sapiens) 		4 / 8 ASN B 165
SER B 153
TYR B 155
ASN B 150
 None
None
None
NAG  B 903 (-1.9A)
 1.09A 2wekB-3wo4B:
undetectable		 2wekB-3wo4B:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3wo4 INTERLEUKIN-18
RECEPTOR 1
INTERLEUKIN-18
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens) 		4 / 5 THR C 247
GLU B 273
THR B 271
HIS B 277
 None
 1.42A 3glqB-3wo4C:
undetectable		 3glqB-3wo4C:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3wo4 INTERLEUKIN-18
RECEPTOR 1
INTERLEUKIN-18
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens) 		4 / 5 THR C 247
GLU B 273
THR B 271
HIS B 277
 None
 1.48A 3n58A-3wo4C:
undetectable		 3n58A-3wo4C:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3wo4 INTERLEUKIN-18
RECEPTOR 1
(Homo
sapiens) 		4 / 6 GLU B 266
THR B 299
ALA B 278
ALA B 239
 None
 1.25A 3ns1C-3wo4B:
undetectable		 3ns1C-3wo4B:
17.07