SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wo5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MIH_A_CUA358_0 (PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE)	3wo5	AP-4-A PHOSPHORYLASE (Mycobacterium tuberculosis)	3 / 3	HIS A 91 HIS A 155 MET A 93	None PO4 A 301 (-3.9A) PG4 A 302 (-4.9A)	0.79A	3mihA-3wo5A: undetectable	3mihA-3wo5A: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MIH_A_CUA358_0 (PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE)	3wo5	AP-4-A PHOSPHORYLASE (Mycobacterium tuberculosis)	3 / 3	HIS A 155 HIS A 153 MET A 93	PO4 A 301 (-3.9A) PO4 A 301 (-3.9A) PG4 A 302 (-4.9A)	0.93A	3mihA-3wo5A: undetectable	3mihA-3wo5A: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ND7_B_TA1B601_2 (TUBULIN BETA-2B CHAIN)	3wo5	AP-4-A PHOSPHORYLASE (Mycobacterium tuberculosis)	3 / 3	THR A 183 PRO A 131 ARG A 130	None	0.59A	5nd7B-3wo5A: undetectable	5nd7B-3wo5A: 18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SXQ_A_NIZA808_1 (CATALASE-PEROXIDASE)	3wo5	AP-4-A PHOSPHORYLASE (Mycobacterium tuberculosis)	4 / 8	GLU A 104 GLU A 102 VAL A 100 LEU A 138	None	1.01A	5sxqA-3wo5A: undetectable	5sxqA-3wo5A: 15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SXQ_B_NIZB808_1 (CATALASE-PEROXIDASE)	3wo5	AP-4-A PHOSPHORYLASE (Mycobacterium tuberculosis)	4 / 8	GLU A 104 GLU A 102 VAL A 100 LEU A 138	None	1.00A	5sxqB-3wo5A: undetectable	5sxqB-3wo5A: 15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYJ_A_NIZA809_1 (CATALASE-PEROXIDASE)	3wo5	AP-4-A PHOSPHORYLASE (Mycobacterium tuberculosis)	4 / 8	GLU A 104 GLU A 102 VAL A 100 LEU A 138	None	1.04A	5syjA-3wo5A: undetectable	5syjA-3wo5A: 15.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3MIH_A_CUA358_0","PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE","3wo5","AP-4-A PHOSPHORYLASE","Mycobacterium tuberculosis",3,"HIS A  91;HIS A 155;MET A  93","None;PO4 A 301 (-3.9A);PG4 A 302 (-4.9A)","0.79A","3mihA-3wo5A:undetectable","3mihA-3wo5A:20.50"],["3MIH_A_CUA358_0","PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE","3wo5","AP-4-A PHOSPHORYLASE","Mycobacterium tuberculosis",3,"HIS A 155;HIS A 153;MET A  93","PO4 A 301 (-3.9A);PO4 A 301 (-3.9A);PG4 A 302 (-4.9A)","0.93A","3mihA-3wo5A:undetectable","3mihA-3wo5A:20.50"],["5ND7_B_TA1B601_2","TUBULIN BETA-2B CHAIN","3wo5","AP-4-A PHOSPHORYLASE","Mycobacterium tuberculosis",3,"THR A 183;PRO A 131;ARG A 130","None","0.59A","5nd7B-3wo5A:undetectable","5nd7B-3wo5A:18.59"],["5SXQ_A_NIZA808_1","CATALASE-PEROXIDASE","3wo5","AP-4-A PHOSPHORYLASE","Mycobacterium tuberculosis",4,"GLU A 104;GLU A 102;VAL A 100;LEU A 138","None","1.01A","5sxqA-3wo5A:undetectable","5sxqA-3wo5A:15.77"],["5SXQ_B_NIZB808_1","CATALASE-PEROXIDASE","3wo5","AP-4-A PHOSPHORYLASE","Mycobacterium tuberculosis",4,"GLU A 104;GLU A 102;VAL A 100;LEU A 138","None","1.00A","5sxqB-3wo5A:undetectable","5sxqB-3wo5A:15.77"],["5SYJ_A_NIZA809_1","CATALASE-PEROXIDASE","3wo5","AP-4-A PHOSPHORYLASE","Mycobacterium tuberculosis",4,"GLU A 104;GLU A 102;VAL A 100;LEU A 138","None","1.04A","5syjA-3wo5A:undetectable","5syjA-3wo5A:15.77"]]