SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wo8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		4 / 6 MET A 207
LEU A 223
ALA A 221
LEU A 219
 None
 1.10A 1etb1-3wo8A:
undetectable		 1etb1-3wo8A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 12 LEU A 198
GLY A 143
ALA A 144
GLY A 149
LEU A 151
 None
 1.06A 1fe2A-3wo8A:
undetectable		 1fe2A-3wo8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 12 LEU A 198
GLY A 143
ALA A 144
GLY A 149
LEU A 151
 None
 1.08A 1igxA-3wo8A:
undetectable		 1igxA-3wo8A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 12 CYH A 158
THR A 208
GLY A 164
ASP A 117
ALA A 146
 None
 1.35A 1oltA-3wo8A:
undetectable		 1oltA-3wo8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		4 / 6 ARG A 430
ALA A 405
ILE A 370
PRO A 352
 None
 1.04A 1oniH-3wo8A:
undetectable
1oniI-3wo8A:
undetectable		 1oniH-3wo8A:
13.88
1oniI-3wo8A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		4 / 6 PRO A  89
ALA A 144
GLU A 201
GLU A 148
 None
 1.32A 1qhyA-3wo8A:
undetectable		 1qhyA-3wo8A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		3 / 3 LEU A 223
LEU A 219
SER A 218
 None
 0.62A 1tlmA-3wo8A:
undetectable		 1tlmA-3wo8A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		6 / 12 ILE A  60
SER A  61
ILE A  34
ASN A 109
VAL A  38
VAL A  71
 None
 1.39A 2nnhA-3wo8A:
undetectable		 2nnhA-3wo8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 12 GLY A 143
LEU A 119
GLY A 133
ASN A  81
LEU A  82
 None
 0.80A 2nxeA-3wo8A:
undetectable		 2nxeA-3wo8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 12 GLY A 143
LEU A 119
GLY A 133
ASN A  81
LEU A  82
 None
 0.81A 2nxeB-3wo8A:
undetectable		 2nxeB-3wo8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		4 / 8 GLY A 164
HIS A 165
ILE A 159
ALA A 221
 None
 0.92A 2x0pA-3wo8A:
undetectable		 2x0pA-3wo8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 12 THR A 446
LEU A 429
ILE A 373
VAL A 383
LEU A 349
 None
 1.45A 3a51B-3wo8A:
undetectable		 3a51B-3wo8A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 12 GLY A 100
GLY A 143
ALA A 144
GLY A 149
LEU A 151
 None
 0.92A 3hs6B-3wo8A:
0.0		 3hs6B-3wo8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		4 / 6 LEU A 266
SER A 263
PHE A 265
ILE A 273
 None
 1.00A 3ko0B-3wo8A:
undetectable		 3ko0B-3wo8A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 9 PHE A  16
ARG A  25
ILE A  24
ASP A 277
GLY A  12
 None
 1.48A 4eb4C-3wo8A:
undetectable		 4eb4C-3wo8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		3 / 3 LYS A 442
TYR A 426
ARG A 441
 None
 1.35A 4gc9A-3wo8A:
undetectable		 4gc9A-3wo8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 10 TYR A  95
VAL A 111
GLY A  66
SER A  96
GLY A 100
 None
 1.04A 4mmcA-3wo8A:
undetectable		 4mmcA-3wo8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 9 TYR A  95
VAL A 111
GLY A  66
SER A  96
GLY A 100
 None
 1.04A 4mmfA-3wo8A:
undetectable		 4mmfA-3wo8A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 9 TYR A  95
VAL A 111
GLY A  66
SER A  96
GLY A 100
 None
 1.08A 4mmfB-3wo8A:
undetectable		 4mmfB-3wo8A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		4 / 6 LEU A 223
THR A 175
LEU A 219
SER A 218
 None
 1.00A 4pwjA-3wo8A:
undetectable		 4pwjA-3wo8A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		4 / 8 LEU A  33
GLY A  12
MET A 249
GLU A 248
 None
 0.88A 4rjdA-3wo8A:
undetectable
4rjdB-3wo8A:
undetectable		 4rjdA-3wo8A:
11.60
4rjdB-3wo8A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 12 GLY A 240
GLY A 237
LEU A 198
ARG A 304
LEU A 241
 None
 1.04A 5c0oH-3wo8A:
undetectable		 5c0oH-3wo8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 11 VAL A 425
VAL A 444
PHE A 403
ILE A 373
ILE A 454
 None
 1.00A 5e4dB-3wo8A:
undetectable		 5e4dB-3wo8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 12 GLY A   6
TYR A 285
TYR A  27
PHE A  51
LEU A  52
 None
 1.27A 5kklB-3wo8A:
undetectable		 5kklB-3wo8A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 12 ASP A  63
PHE A 112
ARG A 130
LYS A 160
MET A 207
 None
 1.18A 5m6gA-3wo8A:
29.7		 5m6gA-3wo8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 12 ASP A  63
PHE A 112
LYS A 160
HIS A 161
MET A 207
 None
 0.51A 5m6gA-3wo8A:
29.7		 5m6gA-3wo8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 12 LEU A  33
PHE A 112
ARG A 130
LYS A 160
MET A 207
 None
 1.21A 5m6gA-3wo8A:
29.7		 5m6gA-3wo8A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE
(Thermotoga
maritima) 		5 / 12 LEU A  33
PHE A 112
LYS A 160
HIS A 161
MET A 207
 None
 0.90A 5m6gA-3wo8A:
29.7		 5m6gA-3wo8A:
24.34