SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wpw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 3wpw POMB
(Vibrio
alginolyticus) 		5 / 9 LEU A 210
GLU A 216
VAL A 296
PHE A 196
MET A 190
 None
 1.24A 1gx8A-3wpwA:
undetectable		 1gx8A-3wpwA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 3wpw POMB
(Vibrio
alginolyticus) 		5 / 11 LEU A 210
GLU A 216
VAL A 296
PHE A 196
MET A 190
 None
 1.33A 1gx9A-3wpwA:
undetectable		 1gx9A-3wpwA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3wpw POMB
(Vibrio
alginolyticus) 		4 / 5 LEU A 160
ILE A 188
ILE A 214
ALA A 215
 None
 0.70A 2i2zA-3wpwA:
undetectable		 2i2zA-3wpwA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3wpw POMB
(Vibrio
alginolyticus) 		3 / 3 GLN A 250
THR A 231
TRP A 245
 None
 1.19A 2rctA-3wpwA:
undetectable		 2rctA-3wpwA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3wpw POMB
(Vibrio
alginolyticus) 		3 / 3 ARG A 189
GLU A 178
SER A 286
 None
ACT  A 401 (-4.4A)
None
 0.89A 2xctD-3wpwA:
1.8		 2xctD-3wpwA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3wpw POMB
(Vibrio
alginolyticus) 		5 / 12 LEU A 203
PHE A 207
ARG A 295
VAL A 227
ILE A 188
 None
 1.46A 2xpwA-3wpwA:
undetectable		 2xpwA-3wpwA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3wpw POMB
(Vibrio
alginolyticus) 		4 / 7 GLU A 192
LEU A 247
ARG A 294
THR A 231
 None
 1.25A 3mbgA-3wpwA:
undetectable
3mbgB-3wpwA:
undetectable		 3mbgA-3wpwA:
16.84
3mbgB-3wpwA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3wpw POMB
(Vibrio
alginolyticus) 		5 / 11 TYR A 241
GLY A 274
ALA A 276
ALA A 252
GLN A 250
 None
 1.06A 3nmuB-3wpwA:
undetectable
3nmuJ-3wpwA:
undetectable		 3nmuB-3wpwA:
18.44
3nmuJ-3wpwA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA303_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 3wpw POMB
(Vibrio
alginolyticus) 		4 / 4 LEU A 182
VAL A 187
GLU A 180
ARG A 189
 None
 1.27A 4ww7A-3wpwA:
0.4		 4ww7A-3wpwA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3wpw POMB
(Vibrio
alginolyticus) 		4 / 7 GLY A 199
PHE A 196
GLU A 192
ASN A 244
 None
 1.00A 5n5dB-3wpwA:
undetectable		 5n5dB-3wpwA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 3wpw POMB
(Vibrio
alginolyticus) 		5 / 12 MET A 190
ALA A 252
ILE A 214
VAL A 225
PHE A 265
 None
 1.31A 5vlmB-3wpwA:
undetectable		 5vlmB-3wpwA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGG_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 3wpw POMB
(Vibrio
alginolyticus) 		5 / 12 THR A 278
ASN A 293
ARG A 295
VAL A 227
VAL A 272
 None
 1.49A 5wggA-3wpwA:
undetectable		 5wggA-3wpwA:
16.40