SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		5 / 12 ASP A 111
GLU A 302
VAL A 107
ILE A 113
ILE A  86
 None
 0.95A 1fapA-3wq1A:
undetectable		 1fapA-3wq1A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		5 / 12 ASP A 111
GLU A 302
VAL A 107
ILE A 113
ILE A  86
 None
 1.05A 1fklA-3wq1A:
undetectable		 1fklA-3wq1A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		5 / 12 PHE A 157
VAL A 285
ILE A 200
VAL A 219
SER A 266
 None
None
None
GOL  A 410 ( 4.8A)
None
 1.22A 1fm4A-3wq1A:
undetectable		 1fm4A-3wq1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		5 / 12 GLY A 288
MET A  95
LEU A 104
LEU A 159
TYR A 261
 None
None
NHE  A 407 ( 4.1A)
None
None
 1.40A 1fm6D-3wq1A:
undetectable		 1fm6D-3wq1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		5 / 12 ALA A 269
GLY A 262
ILE A 318
LEU A 159
ILE A 145
 None
 1.00A 1x1aA-3wq1A:
undetectable		 1x1aA-3wq1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		4 / 7 TRP A 186
GLY A 131
THR A 141
SER A 149
 None
None
NHE  A 404 (-3.6A)
None
 1.26A 2o5yH-3wq1A:
undetectable
2o5yL-3wq1A:
undetectable		 2o5yH-3wq1A:
22.35
2o5yL-3wq1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		4 / 9 ILE A 271
PHE A 246
VAL A 234
GLU A 216
 None
 0.74A 2vufA-3wq1A:
undetectable		 2vufA-3wq1A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		3 / 3 TYR A 243
GLU A 178
ASN A  82
 GOL  A 409 (-4.6A)
BGC  A 414 (-3.9A)
BGC  A 412 (-3.1A)
 0.96A 2y7hC-3wq1A:
undetectable		 2y7hC-3wq1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		5 / 12 VAL A 244
ILE A 217
ILE A 221
VAL A 257
TYR A 163
 None
GOL  A 410 ( 4.0A)
None
None
None
 1.28A 3g8iA-3wq1A:
undetectable		 3g8iA-3wq1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		5 / 9 ASN A 132
TYR A 130
GLY A 131
ASP A 284
LEU A 310
 CA  A 402 (-3.2A)
None
None
None
None
 1.48A 3sfuB-3wq1A:
undetectable		 3sfuB-3wq1A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		4 / 7 TYR A 281
ARG A 187
ILE A 191
GLU A 279
 None
 1.09A 4a97E-3wq1A:
undetectable		 4a97E-3wq1A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		5 / 11 ILE A 259
LEU A 310
ASP A 156
GLY A 262
PHE A 264
 None
 1.30A 4fogA-3wq1A:
undetectable		 4fogA-3wq1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		5 / 11 ILE A 259
LEU A 310
ASP A 156
GLY A 262
PHE A 264
 None
 1.40A 4foxF-3wq1A:
undetectable		 4foxF-3wq1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		3 / 3 TYR A 158
THR A 160
THR A 311
 None
 0.59A 5aoxB-3wq1A:
undetectable		 5aoxB-3wq1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		3 / 3 TYR A 158
THR A 160
THR A 311
 None
 0.59A 5aoxE-3wq1A:
undetectable		 5aoxE-3wq1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		3 / 3 GLU A 127
TRP A  84
ASN A 136
 BGC  A 413 ( 4.9A)
BGC  A 413 (-3.8A)
BGC  A 412 ( 3.9A)
 1.13A 5dv4A-3wq1A:
undetectable		 5dv4A-3wq1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		5 / 11 ILE A 287
VAL A 257
PHE A 175
LEU A 310
THR A 309
 None
 1.48A 5tiyA-3wq1A:
undetectable		 5tiyA-3wq1A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		5 / 9 ILE A 202
ILE A 200
GLU A 254
VAL A 257
ILE A 259
 None
 1.35A 6hloA-3wq1A:
undetectable		 6hloA-3wq1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		5 / 12 ILE A 259
LEU A 310
ASP A 156
GLY A 262
PHE A 264
 None
 1.31A 6r2eA-3wq1A:
undetectable		 6r2eA-3wq1A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 3wq1 ENDOGLUCANASE A
(Pyrococcus
furiosus) 		5 / 11 ILE A 259
LEU A 310
ASP A 156
GLY A 262
PHE A 264
 None
 1.33A 6r2eG-3wq1A:
undetectable		 6r2eG-3wq1A:
19.15