SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wr7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 5 ARG A   8
ASP A  14
GLU A  61
LYS A  66
 None
 1.29A 2xrzA-3wr7A:
undetectable
2xrzB-3wr7A:
undetectable		 2xrzA-3wr7A:
18.26
2xrzB-3wr7A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 PHE A  84
GLY A 109
ILE A 162
ASP A 107
THR A 111
 None
 1.33A 3a25A-3wr7A:
undetectable		 3a25A-3wr7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 11 LEU A 118
ALA A 102
ALA A 105
LEU A 113
PHE A 138
 None
 1.27A 3bszE-3wr7A:
undetectable		 3bszE-3wr7A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 7 TYR A  30
VAL A 122
ILE A 130
ASN A 126
 COA  A 202 (-3.4A)
COA  A 202 ( 4.8A)
None
COA  A 202 ( 4.7A)
 1.09A 4a97E-3wr7A:
undetectable		 4a97E-3wr7A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 8 TYR A  30
VAL A 122
ILE A 130
ASN A 126
 COA  A 202 (-3.4A)
COA  A 202 ( 4.8A)
None
COA  A 202 ( 4.7A)
 1.05A 4a97C-3wr7A:
undetectable		 4a97C-3wr7A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 8 TYR A  30
VAL A 122
ILE A 130
ASN A 126
 COA  A 202 (-3.4A)
COA  A 202 ( 4.8A)
None
COA  A 202 ( 4.7A)
 1.04A 4a97D-3wr7A:
undetectable		 4a97D-3wr7A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 8 TYR A  30
VAL A 122
ILE A 130
ASN A 126
 COA  A 202 (-3.4A)
COA  A 202 ( 4.8A)
None
COA  A 202 ( 4.7A)
 1.07A 4a97G-3wr7A:
undetectable		 4a97G-3wr7A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 7 TYR A  30
VAL A 122
ILE A 130
ASN A 126
 COA  A 202 (-3.4A)
COA  A 202 ( 4.8A)
None
COA  A 202 ( 4.7A)
 1.11A 4a97H-3wr7A:
undetectable		 4a97H-3wr7A:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 6 GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.89A 4mi4A-3wr7A:
28.6		 4mi4A-3wr7A:
53.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 7 GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.84A 4mi4B-3wr7A:
28.9
4mi4C-3wr7A:
28.6		 4mi4B-3wr7A:
53.65
4mi4C-3wr7A:
53.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 7 GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.82A 4mi4A-3wr7A:
28.6
4mi4C-3wr7A:
28.6		 4mi4A-3wr7A:
53.65
4mi4C-3wr7A:
53.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 8 MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.79A 4mj8A-3wr7A:
28.7
4mj8C-3wr7A:
28.7		 4mj8A-3wr7A:
57.06
4mj8C-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		7 / 8 TRP A  31
GLU A  33
GLU A  74
GLU A  83
GLN A  85
ILE A  86
LEU A 120
 COA  A 202 (-4.8A)
SPD  A 201 (-3.9A)
None
None
COA  A 202 ( 4.7A)
COA  A 202 (-4.1A)
COA  A 202 ( 4.6A)
 0.87A 4mj8A-3wr7A:
28.7		 4mj8A-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 8 MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.78A 4mj8B-3wr7A:
28.8
4mj8C-3wr7A:
28.7		 4mj8B-3wr7A:
57.06
4mj8C-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 7 MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.64A 4mj8C-3wr7A:
28.7		 4mj8C-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 5 GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.63A 4r87E-3wr7A:
28.3		 4r87E-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_G_SPMG202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 9 MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.73A 4r87E-3wr7A:
28.3
4r87G-3wr7A:
28.6		 4r87E-3wr7A:
57.06
4r87G-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 6 MET A  28
GLU A  33
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.73A 4r87H-3wr7A:
28.1		 4r87H-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 7 MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.55A 4r87I-3wr7A:
28.3		 4r87I-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 7 MET A  28
TRP A  31
GLU A  33
TYR A  36
GLU A  37
GLU A  41
 None
COA  A 202 (-4.8A)
SPD  A 201 (-3.9A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.76A 4r87J-3wr7A:
28.0
4r87L-3wr7A:
27.9		 4r87J-3wr7A:
57.06
4r87L-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R87_K_SPMK202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		7 / 9 MET A  28
TRP A  31
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
COA  A 202 (-4.8A)
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.80A 4r87I-3wr7A:
28.3
4r87K-3wr7A:
28.4		 4r87I-3wr7A:
57.06
4r87K-3wr7A:
57.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE
(Escherichia
coli) 		3 / 3 HIS A  77
ARG A  56
ILE A  75
 None
 0.84A 6fgdA-3wr7A:
2.1		 6fgdA-3wr7A:
17.44