SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wsb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 MET A 291
LEU A 294
SER A 295
 None
 0.66A 1ee2A-3wsbA:
undetectable		 1ee2A-3wsbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 TRP A 225
VAL A 154
TRP A 230
 None
 1.29A 1gmkC-3wsbA:
undetectable
1gmkD-3wsbA:
undetectable		 1gmkC-3wsbA:
4.93
1gmkD-3wsbA:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 PHE A 298
PHE A 202
LEU A 261
VAL A 257
THR A 206
 None
 1.13A 1q23B-3wsbA:
undetectable		 1q23B-3wsbA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 LEU A  67
PHE A 282
GLN A 287
ILE A 138
PHE A  63
 RWZ  A 502 ( 4.4A)
None
None
None
RWZ  A 502 (-3.8A)
 1.24A 1skxA-3wsbA:
2.0		 1skxA-3wsbA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 PHE A 282
SER A  42
GLY A 174
LEU A 175
LEU A 178
 None
FPS  A 501 (-2.6A)
None
FPS  A 501 (-4.3A)
None
 1.08A 2hw2A-3wsbA:
undetectable		 2hw2A-3wsbA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 MET A  56
LEU A  52
LEU A 274
GLY A 172
 None
None
None
FPS  A 501 (-3.6A)
 0.74A 2po5B-3wsbA:
undetectable		 2po5B-3wsbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 LEU A 113
ARG A  68
THR A  72
ALA A  69
 None
 1.07A 3mbgA-3wsbA:
2.7
3mbgB-3wsbA:
2.7		 3mbgA-3wsbA:
17.76
3mbgB-3wsbA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 VAL A 167
ALA A 168
GLY A 169
ALA A 260
TYR A 160
 RWZ  A 502 (-4.3A)
FPS  A 501 (-4.7A)
None
None
None
 1.14A 3qxyA-3wsbA:
undetectable		 3qxyA-3wsbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 11 VAL A 167
ALA A 168
GLY A 169
ALA A 260
TYR A 160
 RWZ  A 502 (-4.3A)
FPS  A 501 (-4.7A)
None
None
None
 1.15A 3rc0A-3wsbA:
undetectable		 3rc0A-3wsbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 VAL A 167
ALA A 168
GLY A 169
ALA A 260
TYR A 160
 RWZ  A 502 (-4.3A)
FPS  A 501 (-4.7A)
None
None
None
 1.13A 3rc0B-3wsbA:
undetectable		 3rc0B-3wsbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 9 ILE A 318
ALA A 290
LEU A 203
ILE A 285
THR A 293
 None
None
RWZ  A 502 (-4.6A)
None
None
 1.23A 3tq8A-3wsbA:
undetectable		 3tq8A-3wsbA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 10 ILE A 318
ALA A 290
LEU A 203
ILE A 285
THR A 293
 None
None
RWZ  A 502 (-4.6A)
None
None
 1.21A 4g8zX-3wsbA:
undetectable		 4g8zX-3wsbA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 HIS A 198
GLY A 200
VAL A 267
HIS A 263
 None
FPS  A 501 ( 3.7A)
None
None
 0.72A 5f8yA-3wsbA:
undetectable		 5f8yA-3wsbA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 HIS A 198
GLY A 200
VAL A 267
HIS A 263
 None
FPS  A 501 ( 3.7A)
None
None
 0.69A 5f8yB-3wsbA:
undetectable		 5f8yB-3wsbA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 VAL A 107
GLU A 214
GLU A 218
 None
 0.90A 5jsdB-3wsbA:
undetectable
5jsdC-3wsbA:
undetectable		 5jsdB-3wsbA:
21.96
5jsdC-3wsbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3wsb FARNESYLTRANSFERASE,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 TYR A  35
ILE A  49
ALA A  59
ASP A  28
 None
 1.15A 6hu9m-3wsbA:
undetectable
6hu9q-3wsbA:
undetectable		 6hu9m-3wsbA:
20.89
6hu9q-3wsbA:
15.93