SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 5 THR A  52
THR A  53
GLU A 241
THR A 173
 None
 1.22A 1d4fB-3wstA:
4.4		 1d4fB-3wstA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 4 VAL A 485
TRP A 457
TRP A 581
 None
 1.34A 1gmkC-3wstA:
undetectable
1gmkD-3wstA:
undetectable		 1gmkC-3wstA:
2.69
1gmkD-3wstA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 12 ILE A 192
GLY A 209
ALA A 212
GLY A 348
SER A 351
 None
 1.06A 1kiaA-3wstA:
7.9		 1kiaA-3wstA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 PHE A 240
LEU A 146
MET A 285
 None
 0.89A 1mx1D-3wstA:
undetectable		 1mx1D-3wstA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 12 ILE A 192
GLY A 209
ALA A 212
GLY A 348
SER A 351
 None
 1.03A 1nbiA-3wstA:
4.7		 1nbiA-3wstA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 12 ILE A 192
GLY A 209
ALA A 212
GLY A 348
SER A 351
 None
 1.02A 1nbiB-3wstA:
4.7		 1nbiB-3wstA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 12 ILE A 548
LEU A 629
ILE A 637
PHE A 639
LEU A 626
 None
 0.97A 2aclG-3wstA:
undetectable		 2aclG-3wstA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 ASN A 638
ILE A 548
MET A 577
 None
 0.82A 2h42C-3wstA:
undetectable		 2h42C-3wstA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 7 MET A 221
ARG A 355
PRO A 287
TRP A 270
 None
PO4  A 702 (-3.9A)
None
None
 1.37A 2hrcA-3wstA:
undetectable		 2hrcA-3wstA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 6 ARG A  42
ASP A  70
LEU A  77
GLY A  76
 SAH  A 701 (-2.7A)
SAH  A 701 ( 4.4A)
None
None
 0.98A 2j2pD-3wstA:
undetectable
2j2pF-3wstA:
undetectable		 2j2pD-3wstA:
15.43
2j2pF-3wstA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 ARG A 122
VAL A 118
THR A  73
 SAH  A 701 (-4.0A)
None
None
 0.76A 2nmzA-3wstA:
undetectable		 2nmzA-3wstA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 ARG A 122
VAL A 118
THR A  73
 SAH  A 701 (-4.0A)
None
None
 0.81A 2nnkA-3wstA:
undetectable		 2nnkA-3wstA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 ARG A  30
GLU A  27
GLN A  26
 None
 0.78A 2p16A-3wstA:
undetectable		 2p16A-3wstA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 VAL A 216
ASP A 215
GLU A 536
 None
 0.64A 2qeuA-3wstA:
undetectable		 2qeuA-3wstA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 VAL A 216
ASP A 215
GLU A 536
 None
 0.64A 2qeuC-3wstA:
undetectable		 2qeuC-3wstA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 6 HIS A 300
GLU A 140
PHE A  46
PRO A 171
 None
SAH  A 701 (-4.4A)
None
None
 1.49A 2qqtA-3wstA:
undetectable		 2qqtA-3wstA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 GLU A 373
HIS A 482
GLU A 480
 None
 0.87A 2x45C-3wstA:
undetectable		 2x45C-3wstA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 5 SER A 594
LEU A 534
GLY A 591
GLU A 602
 None
 1.17A 3aiaA-3wstA:
undetectable
3aiaB-3wstA:
undetectable		 3aiaA-3wstA:
16.12
3aiaB-3wstA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 6 MET A 221
ARG A 355
PRO A 287
TRP A 270
 None
PO4  A 702 (-3.9A)
None
None
 1.32A 3aqiA-3wstA:
3.2		 3aqiA-3wstA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 8 HIS A 360
GLY A 606
ASN A 604
PHE A 370
 None
 1.29A 3ccfA-3wstA:
8.5		 3ccfA-3wstA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 9 ALA A 158
LEU A 152
PRO A 171
VAL A 169
ILE A 137
 None
 1.12A 3em4B-3wstA:
undetectable		 3em4B-3wstA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 12 LEU A 186
ASP A 265
VAL A 181
ILE A 264
TYR A 307
 None
 1.07A 3hgiA-3wstA:
undetectable		 3hgiA-3wstA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 8 GLU A 310
LYS A 311
ASN A 335
ILE A 264
 None
 1.24A 3kp6A-3wstA:
undetectable
3kp6B-3wstA:
undetectable		 3kp6A-3wstA:
14.10
3kp6B-3wstA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 LEU A 486
TRP A 578
GLY A 591
 None
 0.78A 3l35A-3wstA:
undetectable
3l35H-3wstA:
undetectable		 3l35A-3wstA:
5.91
3l35H-3wstA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 6 GLY A  74
THR A  75
LEU A  77
GLU A  94
ASP A  70
 SAH  A 701 ( 3.8A)
None
None
SAH  A 701 (-2.7A)
SAH  A 701 ( 4.4A)
 1.27A 3ps9A-3wstA:
4.4		 3ps9A-3wstA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 ARG A 122
VAL A 118
THR A  73
 SAH  A 701 (-4.0A)
None
None
 0.82A 3pwrA-3wstA:
undetectable		 3pwrA-3wstA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 ARG A 122
VAL A 118
THR A  73
 SAH  A 701 (-4.0A)
None
None
 0.85A 3tl9A-3wstA:
undetectable		 3tl9A-3wstA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 5 HIS A 300
THR A 144
GLU A 140
ASP A  70
 None
None
SAH  A 701 (-4.4A)
SAH  A 701 ( 4.4A)
 1.37A 3tm4A-3wstA:
9.1		 3tm4A-3wstA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 5 HIS A 300
THR A 144
GLU A 140
ASP A  70
 None
None
SAH  A 701 (-4.4A)
SAH  A 701 ( 4.4A)
 1.40A 3tm4B-3wstA:
9.0		 3tm4B-3wstA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 9 LEU A  78
ASP A  70
ALA A  92
GLY A 100
LEU A  77
 SAH  A 701 (-3.9A)
SAH  A 701 ( 4.4A)
None
None
None
 0.87A 3u7sA-3wstA:
undetectable		 3u7sA-3wstA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_SALA1505_1
(FERROCHELATASE,
MITOCHONDRIAL)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 9 VAL A 611
PRO A 576
TRP A 603
LEU A 534
LEU A 496
 None
 1.40A 3w1wA-3wstA:
2.1
3w1wB-3wstA:
2.1		 3w1wA-3wstA:
20.85
3w1wB-3wstA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 12 GLU A 447
PHE A 370
ASP A 465
GLY A 387
SER A 390
 None
 1.29A 4djfA-3wstA:
undetectable		 4djfA-3wstA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 6 PHE A 639
ALA A 628
ALA A 488
LEU A 486
 None
 0.98A 4dtzA-3wstA:
undetectable		 4dtzA-3wstA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 6 GLY A 584
PRO A 481
GLY A 484
GLU A 580
 None
 0.85A 4dxuA-3wstA:
undetectable		 4dxuA-3wstA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 9 ASP A 276
GLY A 279
PHE A 282
SER A 172
GLY A 174
 None
 1.37A 4mmeA-3wstA:
undetectable		 4mmeA-3wstA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 9 ASP A 276
GLY A 279
PHE A 282
SER A 172
GLY A 174
 None
 1.36A 4mmfA-3wstA:
undetectable		 4mmfA-3wstA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 9 ALA A 158
ARG A 153
ARG A 122
ILE A  71
ILE A 137
 None
None
SAH  A 701 (-4.0A)
SAH  A 701 (-4.6A)
None
 1.47A 4oknB-3wstA:
5.4		 4oknB-3wstA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 4 ILE A 637
ASN A 638
ILE A 528
VAL A 529
 None
 0.97A 4uy87-3wstA:
undetectable		 4uy87-3wstA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 5 PRO A 171
VAL A 170
ALA A 139
PHE A  46
 None
 1.27A 4z4cA-3wstA:
2.0		 4z4cA-3wstA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 9 TYR A 419
ILE A 405
GLY A 389
LEU A 349
LEU A 204
 None
 1.25A 4ze0A-3wstA:
undetectable		 4ze0A-3wstA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 ASP A 339
ASN A 335
PHE A 333
 None
 0.79A 5dsgB-3wstA:
undetectable		 5dsgB-3wstA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 5 SER A 572
SER A 570
SER A 571
SER A 623
 None
 1.37A 5hswA-3wstA:
undetectable		 5hswA-3wstA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 12 TYR A 607
SER A 390
LEU A 392
VAL A 361
PHE A 370
 None
 1.37A 5jo9A-3wstA:
4.5		 5jo9A-3wstA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 7 ILE A  37
LEU A  77
MET A  81
LEU A  78
 None
None
None
SAH  A 701 (-3.9A)
 0.78A 5u4sA-3wstA:
4.6		 5u4sA-3wstA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 8 ILE A  37
LEU A  77
MET A  81
LEU A  78
 None
None
None
SAH  A 701 (-3.9A)
 0.79A 5u4sB-3wstA:
5.1		 5u4sB-3wstA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 12 ARG A 522
LEU A  28
PHE A 513
ALA A 103
GLY A 504
 None
 1.13A 5veuA-3wstA:
undetectable		 5veuA-3wstA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 THR A 154
THR A 124
ARG A 122
 SAH  A 701 (-3.4A)
SAH  A 701 ( 4.9A)
SAH  A 701 (-4.0A)
 1.07A 5wm2A-3wstA:
2.2		 5wm2A-3wstA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		5 / 12 ILE A 517
ALA A 521
LEU A  28
ALA A  29
ILE A 106
 None
 0.82A 6a5yD-3wstA:
undetectable		 6a5yD-3wstA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		4 / 5 LEU A 511
THR A  75
THR A 107
GLY A  76
 None
 1.20A 6gtqA-3wstA:
undetectable		 6gtqA-3wstA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7
(Caenorhabditis
elegans) 		3 / 3 TRP A 603
ILE A 489
GLU A 580
 None
 0.81A 6hcxA-3wstA:
undetectable		 6hcxA-3wstA:
9.00