SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wsu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		4 / 7 GLU A 273
VAL A 102
TRP A  80
ASN A 177
 NA  A 402 (-2.8A)
None
None
NA  A 402 ( 4.8A)
 1.30A 1jqdA-3wsuA:
undetectable		 1jqdA-3wsuA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		3 / 3 ASP A 137
THR A 139
GLU A 273
 None
None
NA  A 402 (-2.8A)
 0.84A 1pj7A-3wsuA:
undetectable		 1pj7A-3wsuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		4 / 5 GLY A 221
GLN A 220
TRP A 219
VAL A 248
 None
 1.43A 1zzuB-3wsuA:
undetectable		 1zzuB-3wsuA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		4 / 8 THR A  98
LEU A 301
VAL A 270
GLY A 299
 None
 0.92A 2a1oA-3wsuA:
undetectable		 2a1oA-3wsuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		5 / 12 LEU A 164
VAL A 101
HIS A  78
CYH A 124
VAL A 120
 None
 1.26A 2g70A-3wsuA:
undetectable		 2g70A-3wsuA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		5 / 12 LEU A 164
VAL A 101
HIS A  78
CYH A 124
VAL A 120
 None
 1.29A 2g70B-3wsuA:
undetectable		 2g70B-3wsuA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		5 / 12 LEU A 164
VAL A 101
HIS A  78
CYH A 124
VAL A 120
 None
 1.34A 2g72A-3wsuA:
undetectable		 2g72A-3wsuA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		5 / 12 LEU A 164
VAL A 101
HIS A  78
CYH A 124
VAL A 120
 None
 1.32A 2g72B-3wsuA:
undetectable		 2g72B-3wsuA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		3 / 3 GLN A 217
THR A 139
TRP A 303
 None
 1.18A 2rctA-3wsuA:
undetectable		 2rctA-3wsuA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		6 / 12 ASN A 177
GLU A 178
HIS A 244
TYR A 246
GLU A 273
ASN A 308
 NA  A 402 ( 4.8A)
NA  A 402 (-2.8A)
None
GOL  A 403 (-4.6A)
NA  A 402 (-2.8A)
None
 1.14A 2v3dA-3wsuA:
16.1		 2v3dA-3wsuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		6 / 12 ASN A 177
GLU A 178
HIS A 244
TYR A 246
GLU A 273
TRP A 303
 NA  A 402 ( 4.8A)
NA  A 402 (-2.8A)
None
GOL  A 403 (-4.6A)
NA  A 402 (-2.8A)
None
 0.66A 2v3dA-3wsuA:
16.1		 2v3dA-3wsuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		5 / 11 ASN A 177
GLU A 178
TYR A 246
GLU A 273
TRP A 303
 NA  A 402 ( 4.8A)
NA  A 402 (-2.8A)
GOL  A 403 (-4.6A)
NA  A 402 (-2.8A)
None
 0.74A 2v3dB-3wsuA:
15.5		 2v3dB-3wsuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		5 / 9 ALA A 345
GLU A  63
LEU A  54
LEU A 240
THR A 346
 None
 1.29A 3fl9H-3wsuA:
undetectable		 3fl9H-3wsuA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		4 / 8 PHE A 262
ASP A 218
TYR A 258
LEU A 239
 None
 1.22A 3jq7B-3wsuA:
2.1		 3jq7B-3wsuA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		5 / 12 LEU A 129
ASP A  90
GLY A 328
ALA A  96
GLY A  95
 None
 0.92A 3ku1C-3wsuA:
undetectable		 3ku1C-3wsuA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		5 / 11 GLY A 176
GLU A 134
LEU A 103
ASN A 112
LEU A 133
 None
 1.33A 3ndvA-3wsuA:
undetectable
3ndvB-3wsuA:
undetectable		 3ndvA-3wsuA:
24.44
3ndvB-3wsuA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		5 / 11 LEU A 133
GLY A 176
GLU A 134
LEU A 103
ASN A 112
 None
 1.30A 3ndvA-3wsuA:
undetectable
3ndvB-3wsuA:
undetectable		 3ndvA-3wsuA:
24.44
3ndvB-3wsuA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		5 / 11 GLY A 176
GLU A 134
LEU A 103
ASN A 112
LEU A 133
 None
 1.32A 3ndvC-3wsuA:
undetectable
3ndvD-3wsuA:
undetectable		 3ndvC-3wsuA:
24.44
3ndvD-3wsuA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		5 / 11 LEU A 133
GLY A 176
GLU A 134
LEU A 103
ASN A 112
 None
 1.32A 3ndvC-3wsuA:
undetectable
3ndvD-3wsuA:
undetectable		 3ndvC-3wsuA:
24.44
3ndvD-3wsuA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		5 / 12 PHE A 348
GLY A  64
LEU A  54
GLU A  63
PHE A  69
 None
 1.29A 3tbgC-3wsuA:
undetectable		 3tbgC-3wsuA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		4 / 6 GLU A 178
ASP A 218
ASN A 182
GLU A 143
 NA  A 402 (-2.8A)
None
None
None
 1.32A 3vywA-3wsuA:
undetectable		 3vywA-3wsuA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		4 / 5 GLU A 178
ASP A 218
ASN A 182
GLU A 143
 NA  A 402 (-2.8A)
None
None
None
 1.38A 3vywD-3wsuA:
undetectable		 3vywD-3wsuA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		4 / 6 TYR A 258
ARG A 224
ALA A 225
MET A 223
 None
 1.47A 4o7gB-3wsuA:
0.0		 4o7gB-3wsuA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		3 / 3 GLU A 178
TRP A 188
ASN A 174
 NA  A 402 (-2.8A)
None
None
 1.14A 5dv4A-3wsuA:
2.2		 5dv4A-3wsuA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		5 / 12 SER A 325
LEU A 324
GLY A 328
PHE A 332
LEU A  94
 None
 1.38A 5jo9A-3wsuA:
undetectable		 5jo9A-3wsuA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		4 / 4 GLY A 113
PRO A 114
VAL A 117
ARG A 111
 None
 1.20A 5uunA-3wsuA:
undetectable
5uunB-3wsuA:
undetectable		 5uunA-3wsuA:
22.10
5uunB-3wsuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 3wsu BETA-MANNANASE
(Streptomyces
thermolilacinus) 		4 / 7 GLY A 299
TYR A 300
GLU A 340
GLY A 337
 None
 0.87A 6n7fA-3wsuA:
undetectable		 6n7fA-3wsuA:
12.95