SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wsv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		3 / 3 TRP A 133
ALA A 259
VAL A 143
 None
 0.87A 1c4dA-3wsvA:
undetectable
1c4dB-3wsvA:
undetectable		 1c4dA-3wsvA:
7.34
1c4dB-3wsvA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		4 / 4 THR A 129
LEU A 128
LEU A  94
GLN A  85
 None
 1.14A 1fbmA-3wsvA:
undetectable		 1fbmA-3wsvA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		4 / 8 SER A 122
ASN A  98
ILE A 101
GLY A  14
 None
 0.98A 1meiA-3wsvA:
undetectable		 1meiA-3wsvA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 11 THR A 102
VAL A 120
VAL A 109
ILE A 105
VAL A 106
 None
 1.08A 1phgA-3wsvA:
undetectable		 1phgA-3wsvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 LEU A 306
ASP A 126
GLY A 176
TYR A 265
ILE A 270
 None
 1.36A 1tmxB-3wsvA:
undetectable		 1tmxB-3wsvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 LEU A 306
ASP A 126
GLY A 273
TYR A 265
ILE A 270
 None
 1.36A 1tmxB-3wsvA:
undetectable		 1tmxB-3wsvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 THR A 146
GLY A 147
GLY A 176
THR A 272
ILE A 243
 None
 1.23A 2akeA-3wsvA:
undetectable		 2akeA-3wsvA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 THR A 146
GLY A 147
GLY A 176
THR A 272
ILE A 243
 None
 1.21A 2azxA-3wsvA:
undetectable		 2azxA-3wsvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 THR A 146
GLY A 147
GLY A 176
THR A 272
ILE A 243
 None
 1.23A 2azxB-3wsvA:
undetectable		 2azxB-3wsvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 11 SER A 302
SER A 181
ASN A 123
GLY A 179
HIS A 178
 None
 1.49A 2hmaA-3wsvA:
undetectable		 2hmaA-3wsvA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 SER A 181
SER A 302
ALA A 308
THR A 312
VAL A  95
 None
 1.28A 2nniA-3wsvA:
undetectable		 2nniA-3wsvA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 10 THR A 102
VAL A 120
VAL A 109
ILE A 105
VAL A 106
 None
 1.07A 2qboA-3wsvA:
undetectable		 2qboA-3wsvA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		4 / 6 THR A 102
LEU A 128
VAL A 125
VAL A  16
 None
 1.06A 2zuhA-3wsvA:
undetectable		 2zuhA-3wsvA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_A_PXLA313_1
(PYRIDOXAL KINASE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		4 / 4 SER A 302
HIS A 178
THR A 148
VAL A 125
 None
 1.07A 3fhxA-3wsvA:
2.5		 3fhxA-3wsvA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 THR A 149
LEU A 150
VAL A 244
ILE A 236
VAL A   8
 None
 1.03A 3frqB-3wsvA:
undetectable		 3frqB-3wsvA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 10 LEU A 255
THR A 152
THR A 149
GLY A 172
HIS A 171
 None
 1.43A 3h9uA-3wsvA:
5.8		 3h9uA-3wsvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 10 LEU A 255
THR A 152
THR A 149
GLY A 172
HIS A 171
 None
 1.44A 3h9uC-3wsvA:
5.6		 3h9uC-3wsvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 10 LEU A 255
THR A 152
THR A 149
GLY A 172
HIS A 171
 None
 1.44A 3h9uD-3wsvA:
5.6		 3h9uD-3wsvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 9 LEU A 150
THR A 149
GLY A 145
THR A  80
ILE A  20
 None
 1.19A 3jusB-3wsvA:
undetectable		 3jusB-3wsvA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 9 GLU A 208
VAL A 200
ILE A 159
LEU A 163
ILE A 196
 None
None
None
GOL  A 402 (-4.1A)
None
 1.28A 3jw3B-3wsvA:
undetectable		 3jw3B-3wsvA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 11 GLY A  12
ALA A  81
ILE A  10
ALA A  21
ASP A  37
 None
 1.22A 3nmuB-3wsvA:
undetectable
3nmuJ-3wsvA:
3.4		 3nmuB-3wsvA:
23.33
3nmuJ-3wsvA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 THR A 240
GLY A 237
GLY A  17
ARG A 242
GLN A  27
 None
 1.29A 3tkaA-3wsvA:
4.9		 3tkaA-3wsvA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 VAL A  77
TYR A  68
ILE A  36
THR A 240
ILE A 105
 None
 1.25A 3vrjA-3wsvA:
undetectable
3vrjC-3wsvA:
undetectable		 3vrjA-3wsvA:
21.14
3vrjC-3wsvA:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 ILE A 159
GLU A 208
GLU A 201
HIS A 188
VAL A 170
 None
 1.33A 4a97A-3wsvA:
0.9
4a97B-3wsvA:
undetectable		 4a97A-3wsvA:
22.64
4a97B-3wsvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 ILE A 159
GLU A 208
GLU A 201
HIS A 188
VAL A 170
 None
 1.33A 4a97B-3wsvA:
undetectable
4a97C-3wsvA:
undetectable		 4a97B-3wsvA:
22.64
4a97C-3wsvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		3 / 3 PRO A 195
VAL A 200
HIS A 204
 None
 0.75A 4pevC-3wsvA:
4.2		 4pevC-3wsvA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		4 / 6 LEU A 261
LEU A 306
VAL A 303
PHE A 271
 None
 1.05A 4uswA-3wsvA:
undetectable		 4uswA-3wsvA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		4 / 5 LEU A 128
THR A 240
VAL A  16
ILE A  20
 None
 0.89A 4xe3A-3wsvA:
undetectable		 4xe3A-3wsvA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		4 / 6 LEU A 248
ASP A 279
GLU A 251
ILE A  78
 None
 1.09A 4xi3C-3wsvA:
undetectable		 4xi3C-3wsvA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 GLY A 147
GLY A 273
SER A 276
THR A 148
VAL A 144
 None
 1.12A 5kocB-3wsvA:
3.2		 5kocB-3wsvA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 GLY A  82
GLY A  17
GLY A  14
THR A  18
ILE A  10
 None
 0.97A 5kqrA-3wsvA:
3.7		 5kqrA-3wsvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 GLY A  82
GLY A  17
GLY A  14
THR A  18
ILE A  10
 None
 0.95A 5njvD-3wsvA:
undetectable		 5njvD-3wsvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 10 GLY A 237
GLY A 235
VAL A  16
THR A 240
ILE A  78
 None
 1.17A 6exiA-3wsvA:
4.7		 6exiA-3wsvA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 10 GLY A 237
GLY A 235
VAL A  16
THR A 240
ILE A  78
 None
 1.13A 6exiB-3wsvA:
5.2		 6exiB-3wsvA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 GLY A 237
GLY A 235
VAL A  16
THR A 240
ILE A  78
 None
 1.16A 6exiC-3wsvA:
5.2
6exiD-3wsvA:
5.2		 6exiC-3wsvA:
13.18
6exiD-3wsvA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		5 / 12 GLY A 237
GLY A 235
VAL A  16
THR A 240
ILE A  78
 None
 1.15A 6exiC-3wsvA:
5.2
6exiD-3wsvA:
5.2		 6exiC-3wsvA:
13.18
6exiD-3wsvA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3wsv L-LACTATE
DEHYDROGENASE
(Enterococcus
mundtii) 		4 / 8 ASP A 227
GLY A 235
SER A 239
VAL A  16
 None
 1.01A 6giqL-3wsvA:
2.0
6giqP-3wsvA:
undetectable
6giqT-3wsvA:
undetectable		 6giqL-3wsvA:
21.12
6giqP-3wsvA:
21.50
6giqT-3wsvA:
12.28