SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wt0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 12 ILE A  46
ILE A  81
VAL A 182
LEU A  76
ILE A  11
 None
 1.00A 1df7A-3wt0A:
undetectable		 1df7A-3wt0A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		4 / 6 GLY A  27
ILE A  28
GLN A 351
SER A 367
 None
 1.06A 1rs7B-3wt0A:
undetectable		 1rs7B-3wt0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		3 / 3 LYS A  17
ASP A 210
ASP A 237
 ATP  A 400 (-3.0A)
None
None
 0.77A 2br4A-3wt0A:
undetectable		 2br4A-3wt0A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		4 / 7 ILE A 112
PRO A 142
LEU A 375
ILE A 105
 None
 0.76A 2q83A-3wt0A:
undetectable		 2q83A-3wt0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		4 / 6 ILE A 112
PRO A 142
LEU A 375
ILE A 105
 None
 0.78A 2q83B-3wt0A:
undetectable		 2q83B-3wt0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 12 ILE A 205
LEU A 336
VAL A 304
VAL A 297
GLU A 294
 None
 1.22A 2vn0A-3wt0A:
undetectable		 2vn0A-3wt0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		3 / 3 LYS A 333
LYS A 343
VAL A 344
 None
 1.02A 3brfA-3wt0A:
undetectable		 3brfA-3wt0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 12 SER A 326
VAL A 332
GLY A 331
ALA A 260
LEU A 289
 ATP  A 400 (-3.7A)
None
None
None
None
 0.94A 3hs6A-3wt0A:
undetectable		 3hs6A-3wt0A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 12 PHE A 320
TYR A 217
PHE A 127
THR A  83
ILE A  80
 None
 1.33A 3ld6B-3wt0A:
undetectable		 3ld6B-3wt0A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 12 VAL A 211
GLY A  44
ILE A 158
GLY A  82
ALA A 186
 ATP  A 400 (-4.0A)
ATP  A 400 ( 4.0A)
None
None
None
 0.91A 3sufB-3wt0A:
undetectable		 3sufB-3wt0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 9 ILE A 354
GLY A 353
THR A  33
GLN A  35
GLY A  34
 None
 1.26A 4acaB-3wt0A:
undetectable
4acaC-3wt0A:
undetectable		 4acaB-3wt0A:
25.00
4acaC-3wt0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		4 / 6 GLY A  27
ILE A  28
GLN A 351
SER A 367
 None
 1.14A 4d39B-3wt0A:
undetectable		 4d39B-3wt0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 12 GLU A 209
ASP A 206
GLY A  12
SER A  14
GLN A  35
 ATP  A 400 (-4.4A)
MG  A 401 ( 4.4A)
ATP  A 400 (-3.3A)
ATP  A 400 (-3.7A)
None
 1.37A 4djeB-3wt0A:
undetectable		 4djeB-3wt0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		3 / 3 GLU A 173
ASP A 178
ASP A 181
 None
 0.79A 4gc9A-3wt0A:
undetectable		 4gc9A-3wt0A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		4 / 7 ASP A 185
GLN A 213
ASN A 188
ILE A 192
 None
 0.89A 4ii8A-3wt0A:
undetectable		 4ii8A-3wt0A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		4 / 6 GLY A  27
ILE A  28
GLN A 351
SER A 367
 None
 1.04A 4kcnA-3wt0A:
undetectable		 4kcnA-3wt0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 8 GLN A 213
ASP A 226
ILE A  80
LYS A  77
ILE A 158
 None
None
None
MG  A 401 ( 4.1A)
None
 1.33A 4kttB-3wt0A:
undetectable		 4kttB-3wt0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		3 / 3 GLU A 294
ALA A 260
PHE A 261
 None
 0.65A 4v1fA-3wt0A:
undetectable		 4v1fA-3wt0A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		3 / 3 GLU A 294
ALA A 260
PHE A 261
 None
 0.67A 4v1fC-3wt0A:
undetectable		 4v1fC-3wt0A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 10 GLY A 232
GLU A 251
LYS A 254
GLY A 325
SER A 326
 ATP  A 400 (-3.5A)
ATP  A 400 (-2.8A)
ATP  A 400 (-2.5A)
ATP  A 400 (-3.2A)
ATP  A 400 (-3.7A)
 0.82A 5aqfA-3wt0A:
19.9		 5aqfA-3wt0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 10 GLY A 232
GLU A 251
LYS A 254
GLY A 325
SER A 326
 ATP  A 400 (-3.5A)
ATP  A 400 (-2.8A)
ATP  A 400 (-2.5A)
ATP  A 400 (-3.2A)
ATP  A 400 (-3.7A)
 0.82A 5aqfC-3wt0A:
2.4		 5aqfC-3wt0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 10 GLY A 232
GLU A 251
LYS A 254
GLY A 325
SER A 326
 ATP  A 400 (-3.5A)
ATP  A 400 (-2.8A)
ATP  A 400 (-2.5A)
ATP  A 400 (-3.2A)
ATP  A 400 (-3.7A)
 0.81A 5aqyA-3wt0A:
21.0		 5aqyA-3wt0A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 10 ILE A  56
VAL A  16
THR A  38
ASP A  48
ILE A  41
 None
 1.29A 5lg3F-3wt0A:
undetectable		 5lg3F-3wt0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 10 ILE A  56
VAL A  16
THR A  38
ASP A  48
ILE A  41
 None
 1.24A 5lg3G-3wt0A:
undetectable		 5lg3G-3wt0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 12 VAL A 211
ASP A 210
GLU A 229
LEU A  76
SER A 227
 ATP  A 400 (-4.0A)
None
None
None
None
 1.04A 5m50E-3wt0A:
undetectable		 5m50E-3wt0A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 12 VAL A 211
ASP A 210
GLU A 229
LEU A  78
SER A 227
 ATP  A 400 (-4.0A)
None
None
None
None
 1.10A 5m5cB-3wt0A:
undetectable		 5m5cB-3wt0A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 10 VAL A 211
ASP A 210
GLU A 229
LEU A  78
SER A 227
 ATP  A 400 (-4.0A)
None
None
None
None
 1.09A 5m5cE-3wt0A:
undetectable		 5m5cE-3wt0A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		5 / 12 VAL A 211
ASP A 210
GLU A 229
LEU A  76
SER A 227
 ATP  A 400 (-4.0A)
None
None
None
None
 1.19A 5nd3B-3wt0A:
undetectable		 5nd3B-3wt0A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		4 / 6 GLY A 208
THR A 212
GLN A 213
TYR A 189
 ATP  A 400 (-3.5A)
None
None
None
 1.30A 6ag0A-3wt0A:
undetectable		 6ag0A-3wt0A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 3wt0 CELL DIVISION
PROTEIN FTSA
(Staphylococcus
aureus) 		4 / 6 GLY A 208
THR A 212
GLN A 213
TYR A 189
 ATP  A 400 (-3.5A)
None
None
None
 1.27A 6ag0C-3wt0A:
undetectable		 6ag0C-3wt0A:
10.57