SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wt2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 3wt2 PROTEIN
DISULFIDE-ISOMERASE
(Humicola
insolens) 		4 / 4 ILE A 257
GLN A 253
VAL A 312
PHE A 259
 None
 1.27A 3ieoA-3wt2A:
undetectable		 3ieoA-3wt2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3wt2 PROTEIN
DISULFIDE-ISOMERASE
(Humicola
insolens) 		3 / 3 ASP A 435
LEU A 436
PHE A 439
 None
 0.37A 4pthA-3wt2A:
undetectable		 4pthA-3wt2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3wt2 PROTEIN
DISULFIDE-ISOMERASE
(Humicola
insolens) 		4 / 4 VAL A 392
ILE A 358
ASN A 344
VAL A 339
 None
 1.34A 5ajqA-3wt2A:
undetectable		 5ajqA-3wt2A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 3wt2 PROTEIN
DISULFIDE-ISOMERASE
(Humicola
insolens) 		4 / 5 HIS A 270
ASN A 292
VAL A 289
LEU A 228
 None
 1.47A 5xdhD-3wt2A:
undetectable		 5xdhD-3wt2A:
18.30