SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wtb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 11 ILE A 200
ASP A 238
LEU A 241
GLY A 183
ALA A 205
 None
 1.05A 1b02A-3wtbA:
undetectable		 1b02A-3wtbA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 ILE A 200
ASP A 238
LEU A 241
GLY A 183
ALA A 205
 None
 1.26A 1hvyA-3wtbA:
undetectable		 1hvyA-3wtbA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 ILE A 200
ASP A 238
LEU A 241
GLY A 183
ALA A 205
 None
 1.15A 1hvyB-3wtbA:
undetectable		 1hvyB-3wtbA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 11 ILE A 200
ASP A 238
LEU A 241
GLY A 183
ALA A 205
 None
 1.11A 1ju6A-3wtbA:
undetectable		 1ju6A-3wtbA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 11 ILE A 200
ASP A 238
LEU A 241
GLY A 183
ALA A 205
 None
 1.11A 1ju6D-3wtbA:
undetectable		 1ju6D-3wtbA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 152
ILE A  15
GLY A 137
ALA A 157
GLY A 183
 None
 1.08A 1kiaA-3wtbA:
6.6		 1kiaA-3wtbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 152
ILE A  15
GLY A 137
ALA A 157
GLY A 183
 None
 1.09A 1kiaB-3wtbA:
6.6		 1kiaB-3wtbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 152
ILE A  15
GLY A 137
ALA A 157
GLY A 183
 None
 1.09A 1kiaC-3wtbA:
7.1		 1kiaC-3wtbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 152
ILE A  15
GLY A 137
ALA A 157
GLY A 183
 None
 1.09A 1nbhB-3wtbA:
6.8		 1nbhB-3wtbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 152
ILE A  15
GLY A 137
ALA A 157
GLY A 183
 None
 1.15A 1nbiA-3wtbA:
6.9		 1nbiA-3wtbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 152
ILE A  15
GLY A 137
ALA A 157
GLY A 183
 None
 1.15A 1nbiB-3wtbA:
6.8		 1nbiB-3wtbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 ILE A  19
ALA A  18
GLY A  14
ILE A 215
GLY A  10
 None
 0.80A 2qe6A-3wtbA:
5.4		 2qe6A-3wtbA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 ILE A  19
ALA A  18
GLY A  14
ILE A 215
GLY A  10
 None
 0.83A 2qe6B-3wtbA:
5.0		 2qe6B-3wtbA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 THR A  33
ALA A 115
GLY A  63
GLY A  67
THR A 155
 None
 1.06A 2y7hC-3wtbA:
5.5		 2y7hC-3wtbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 ARG A   4
ILE A   8
ALA A 123
ALA A  84
ALA A   6
 None
 1.01A 3sudC-3wtbA:
undetectable		 3sudC-3wtbA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 11 ILE A  19
ILE A  15
GLY A  14
VAL A 237
GLY A 210
 None
 1.08A 4ac9B-3wtbA:
5.6
4ac9C-3wtbA:
5.6		 4ac9B-3wtbA:
21.08
4ac9C-3wtbA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 ILE A 200
ASP A 238
LEU A 241
GLY A 183
ALA A 205
 None
 1.13A 4eb4A-3wtbA:
undetectable		 4eb4A-3wtbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 ILE A 200
ASP A 238
LEU A 241
GLY A 183
ALA A 205
 None
 1.13A 4eb4B-3wtbA:
undetectable		 4eb4B-3wtbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 ILE A 200
ASP A 238
LEU A 241
GLY A 183
ALA A 205
 None
 1.06A 4foxD-3wtbA:
undetectable		 4foxD-3wtbA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 135
ALA A 167
GLY A 232
ILE A 175
GLY A 171
 None
 1.11A 4obwA-3wtbA:
6.7		 4obwA-3wtbA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 135
ALA A 167
GLY A 232
ILE A 175
GLY A 171
 None
 1.18A 4obwD-3wtbA:
6.3		 4obwD-3wtbA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		6 / 12 ALA A 177
GLY A 165
ALA A 115
MET A 117
PHE A 162
TYR A 135
 None
 1.49A 4r29B-3wtbA:
undetectable		 4r29B-3wtbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 11 ILE A 230
ALA A 233
GLY A 232
GLY A 137
ASN A 178
 None
 1.07A 5ayfA-3wtbA:
undetectable		 5ayfA-3wtbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 7 TYR A  92
ALA A 153
GLY A 141
SER A 138
GLY A 137
 None
 1.29A 5e26A-3wtbA:
undetectable
5e26B-3wtbA:
undetectable		 5e26A-3wtbA:
22.45
5e26B-3wtbA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 11 ILE A 200
ASP A 238
LEU A 241
GLY A 183
ALA A 205
 None
 1.05A 5fctA-3wtbA:
undetectable		 5fctA-3wtbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 10 ILE A 134
PHE A  28
GLY A 130
GLY A 131
MET A 127
 None
 1.38A 5lbtA-3wtbA:
6.2
5lbtB-3wtbA:
6.2		 5lbtA-3wtbA:
26.04
5lbtB-3wtbA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 11 ILE A 200
ASP A 238
LEU A 241
GLY A 183
ALA A 205
 None
 1.13A 6r2eF-3wtbA:
undetectable		 6r2eF-3wtbA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 3wtb PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 ILE A 200
ASP A 238
LEU A 241
GLY A 183
ALA A 205
 None
 1.11A 6r2eH-3wtbA:
undetectable		 6r2eH-3wtbA:
18.81