SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wtc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 GLU A  48
LEU A  23
GLY A  18
GLY A  16
ALA A  14
 None
 1.04A 1httC-3wtcA:
3.1		 1httC-3wtcA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 LEU A  83
THR A 179
ILE A 137
SER A 176
PHE A 128
 None
 1.39A 1xoqA-3wtcA:
undetectable		 1xoqA-3wtcA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 LEU A  83
THR A 179
ILE A 137
SER A 176
PHE A 128
 None
 1.38A 1xoqB-3wtcA:
undetectable		 1xoqB-3wtcA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		4 / 4 ILE A   7
ASP A  75
LEU A  35
ARG A  55
 None
 1.38A 2a7qA-3wtcA:
2.8		 2a7qA-3wtcA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		3 / 3 GLU A 130
GLY A 132
THR A 133
 None
 0.54A 3iazA-3wtcA:
undetectable		 3iazA-3wtcA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 GLY A  81
ASP A  84
VAL A  49
ALA A  30
ALA A  26
 None
 1.09A 3keeB-3wtcA:
undetectable		 3keeB-3wtcA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 GLY A  81
ASP A  84
VAL A  49
ALA A  30
ALA A  26
 None
 1.08A 3keeC-3wtcA:
undetectable		 3keeC-3wtcA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 LEU A 165
GLY A 120
ILE A 137
ILE A  63
ARG A  70
 None
 1.02A 3uj6A-3wtcA:
6.5		 3uj6A-3wtcA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 LEU A  73
THR A  11
ALA A   9
ILE A   7
ILE A  33
 None
 1.00A 3ut5B-3wtcA:
6.8		 3ut5B-3wtcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 VAL A 234
ILE A  63
GLY A 120
ILE A 138
LEU A  25
 None
 1.05A 4iv0A-3wtcA:
6.7		 4iv0A-3wtcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		4 / 4 TYR A 183
THR A  11
VAL A 117
ILE A 138
 None
 1.25A 4jx1F-3wtcA:
undetectable		 4jx1F-3wtcA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 VAL A 234
ILE A  63
GLY A 120
ILE A 138
LEU A  25
 None
 1.05A 4mwzB-3wtcA:
6.7		 4mwzB-3wtcA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 LEU A  73
THR A  11
ALA A   9
ILE A   7
ILE A  33
 None
 0.98A 4o2bB-3wtcA:
7.1		 4o2bB-3wtcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 LEU A  73
THR A  11
ALA A   9
ILE A   7
ILE A  33
 None
 0.98A 4o2bD-3wtcA:
7.2		 4o2bD-3wtcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 9 ASP A  36
VAL A  37
ALA A  90
ILE A 112
ILE A  63
 None
 0.76A 4oknB-3wtcA:
9.9		 4oknB-3wtcA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		4 / 6 ASP A 100
LYS A  96
ARG A 199
ILE A 203
 None
 1.21A 5a06A-3wtcA:
8.8		 5a06A-3wtcA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		4 / 5 ASP A 100
LYS A  96
ARG A 199
ILE A 203
 None
 1.19A 5a06B-3wtcA:
9.0		 5a06B-3wtcA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		4 / 5 ASP A 100
LYS A  96
ARG A 199
ILE A 203
 None
 1.18A 5a06D-3wtcA:
8.8		 5a06D-3wtcA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1344_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		4 / 5 ASP A 100
LYS A  96
ARG A 199
ILE A 203
 None
 1.16A 5a06F-3wtcA:
8.8		 5a06F-3wtcA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		4 / 7 ALA A 231
VAL A 230
TYR A 183
VAL A  10
 None
 0.83A 5ecoD-3wtcA:
undetectable		 5ecoD-3wtcA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 LEU A  73
THR A  11
ALA A   9
ILE A   7
ILE A  33
 None
 0.95A 5mioB-3wtcA:
6.9		 5mioB-3wtcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 LEU A  73
THR A  11
ALA A   9
ILE A   7
ILE A  33
 None
 0.99A 5nm5B-3wtcA:
7.1		 5nm5B-3wtcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 3wtc PUTATIVE
OXIDOREDUCTASE
(Gluconobacter
oxydans) 		5 / 12 LEU A  73
THR A  11
ALA A   9
ILE A   7
ILE A  33
 None
 0.97A 5xiwD-3wtcA:
6.7		 5xiwD-3wtcA:
13.67