SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wtg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 3wtg HEMOGLOBIN SUBUNIT
ALPHA-A
(Dromaius
novaehollandiae) 		5 / 6 ALA A  57
LYS A  60
LYS A  61
ALA A  65
LEU A  83
 None
None
HEM  A 201 (-2.7A)
HEM  A 201 ( 3.8A)
HEM  A 201 ( 4.8A)
 0.73A 1iwhA-3wtgA:
25.6		 1iwhA-3wtgA:
68.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3wtg HEMOGLOBIN SUBUNIT
ALPHA-A
(Dromaius
novaehollandiae) 		4 / 7 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 201 (-3.6A)
HEM  A 201 (-4.7A)
HEM  A 201 (-3.9A)
HEM  A 201 ( 3.2A)
 0.88A 1lh6A-3wtgA:
13.2		 1lh6A-3wtgA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 3wtg HEMOGLOBIN SUBUNIT
ALPHA-A
(Dromaius
novaehollandiae) 		5 / 10 PHE A 128
LEU A 136
HIS A  87
ILE A  76
ALA A  65
 None
None
HEM  A 201 ( 3.2A)
None
HEM  A 201 ( 3.8A)
 0.97A 2bxeB-3wtgA:
2.1		 2bxeB-3wtgA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 3wtg HEMOGLOBIN SUBUNIT
ALPHA-A
(Dromaius
novaehollandiae) 		5 / 12 PHE A 105
PHE A  98
HIS A  87
THR A  28
LEU A  29
 None
HEM  A 201 (-4.0A)
HEM  A 201 ( 3.2A)
None
None
 1.03A 4ac0A-3wtgA:
undetectable		 4ac0A-3wtgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 3wtg HEMOGLOBIN SUBUNIT
ALPHA-A
(Dromaius
novaehollandiae) 		5 / 12 PHE A 105
PHE A  98
HIS A  87
THR A  28
LEU A  32
 None
HEM  A 201 (-4.0A)
HEM  A 201 ( 3.2A)
None
None
 1.38A 4ac0A-3wtgA:
undetectable		 4ac0A-3wtgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3wtg HEMOGLOBIN SUBUNIT
ALPHA-A
(Dromaius
novaehollandiae) 		5 / 12 VAL A  62
PHE A 128
VAL A 109
LEU A 129
VAL A 132
 HEM  A 201 (-3.9A)
None
None
None
None
 1.08A 5tudD-3wtgA:
undetectable		 5tudD-3wtgA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3wtg HEMOGLOBIN SUBUNIT
ALPHA-A
(Dromaius
novaehollandiae) 		5 / 12 ALA A 110
PRO A 114
GLY A 102
LEU A  66
LEU A 129
 None
None
None
HEM  A 201 (-4.8A)
None
 1.16A 5wwsA-3wtgA:
undetectable		 5wwsA-3wtgA:
15.45