SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wuc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3wuc GALECTIN
(Xenopus
laevis) 		4 / 6 LEU A  90
ILE A  61
ASP A 104
PRO A 103
 None
 1.21A 1ditH-3wucA:
undetectable
1ditP-3wucA:
undetectable		 1ditH-3wucA:
16.34
1ditP-3wucA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3wuc GALECTIN
(Xenopus
laevis) 		4 / 6 LEU A  90
ILE A 108
ASP A 104
PRO A 103
 None
 1.19A 1ditH-3wucA:
undetectable
1ditP-3wucA:
undetectable		 1ditH-3wucA:
16.34
1ditP-3wucA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3wuc GALECTIN
(Xenopus
laevis) 		5 / 12 SER A 131
MET A  89
PRO A 103
ASP A 104
ILE A  91
 None
 1.44A 1s14A-3wucA:
undetectable		 1s14A-3wucA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3wuc GALECTIN
(Xenopus
laevis) 		5 / 12 SER A 131
MET A  89
PRO A 103
ASP A 104
ILE A  91
 None
 1.39A 1s14B-3wucA:
undetectable		 1s14B-3wucA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3wuc GALECTIN
(Xenopus
laevis) 		4 / 5 ASN A 125
ARG A  32
ASN A  31
ALA A  27
 MLA  A 203 (-3.9A)
GAL  A 202 (-2.8A)
None
None
 1.28A 3frqA-3wucA:
undetectable		 3frqA-3wucA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3wuc GALECTIN
(Xenopus
laevis) 		4 / 7 ASN A 125
ARG A  32
ASN A  31
ALA A  27
 MLA  A 203 (-3.9A)
GAL  A 202 (-2.8A)
None
None
 1.30A 3frqB-3wucA:
undetectable		 3frqB-3wucA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3wuc GALECTIN
(Xenopus
laevis) 		4 / 6 HIS A  47
ASN A  49
ARG A  32
TRP A  71
 GAL  A 202 ( 3.9A)
GAL  A 202 (-4.0A)
GAL  A 202 (-2.8A)
GAL  A 202 ( 3.7A)
 1.18A 3galA-3wucA:
18.7		 3galA-3wucA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3wuc GALECTIN
(Xenopus
laevis) 		6 / 6 HIS A  47
ASN A  49
ARG A  51
ASN A  64
TRP A  71
GLU A  74
 GAL  A 202 ( 3.9A)
GAL  A 202 (-4.0A)
GLC  A 201 (-2.7A)
GAL  A 202 (-3.9A)
GAL  A 202 ( 3.7A)
GLC  A 201 (-2.8A)
 0.25A 3galA-3wucA:
18.7		 3galA-3wucA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3wuc GALECTIN
(Xenopus
laevis) 		4 / 6 HIS A  47
ASN A  49
ARG A  32
TRP A  71
 GAL  A 202 ( 3.9A)
GAL  A 202 (-4.0A)
GAL  A 202 (-2.8A)
GAL  A 202 ( 3.7A)
 1.16A 3galB-3wucA:
18.3		 3galB-3wucA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3wuc GALECTIN
(Xenopus
laevis) 		6 / 6 HIS A  47
ASN A  49
ARG A  51
ASN A  64
TRP A  71
GLU A  74
 GAL  A 202 ( 3.9A)
GAL  A 202 (-4.0A)
GLC  A 201 (-2.7A)
GAL  A 202 (-3.9A)
GAL  A 202 ( 3.7A)
GLC  A 201 (-2.8A)
 0.25A 3galB-3wucA:
18.3		 3galB-3wucA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 3wuc GALECTIN
(Xenopus
laevis) 		3 / 3 HIS A 135
ARG A  19
GLU A  21
 None
 1.01A 3qf1A-3wucA:
undetectable		 3qf1A-3wucA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 3wuc GALECTIN
(Xenopus
laevis) 		4 / 7 HIS A 135
GLU A 107
ARG A  19
GLU A  21
 None
 1.37A 3ql6A-3wucA:
undetectable		 3ql6A-3wucA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3wuc GALECTIN
(Xenopus
laevis) 		5 / 11 CYH A  48
LEU A  90
ILE A  91
LEU A 129
ILE A 127
 None
 0.98A 4dm8A-3wucA:
undetectable		 4dm8A-3wucA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3wuc GALECTIN
(Xenopus
laevis) 		4 / 5 ASP A  96
PRO A 109
GLU A 107
THR A  99
 None
 1.41A 5uxcA-3wucA:
undetectable		 5uxcA-3wucA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 3wuc GALECTIN
(Xenopus
laevis) 		4 / 7 HIS A  47
ASN A  49
ARG A  32
TRP A  71
 GAL  A 202 ( 3.9A)
GAL  A 202 (-4.0A)
GAL  A 202 (-2.8A)
GAL  A 202 ( 3.7A)
 1.16A 6b8kA-3wucA:
18.6		 6b8kA-3wucA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 3wuc GALECTIN
(Xenopus
laevis) 		6 / 7 HIS A  47
ASN A  49
ARG A  51
ASN A  64
TRP A  71
GLU A  74
 GAL  A 202 ( 3.9A)
GAL  A 202 (-4.0A)
GLC  A 201 (-2.7A)
GAL  A 202 (-3.9A)
GAL  A 202 ( 3.7A)
GLC  A 201 (-2.8A)
 0.28A 6b8kA-3wucA:
18.6		 6b8kA-3wucA:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 3wuc GALECTIN
(Xenopus
laevis) 		4 / 8 HIS A  47
ASN A  49
ARG A  32
TRP A  71
 GAL  A 202 ( 3.9A)
GAL  A 202 (-4.0A)
GAL  A 202 (-2.8A)
GAL  A 202 ( 3.7A)
 1.13A 6b94A-3wucA:
23.9		 6b94A-3wucA:
42.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 3wuc GALECTIN
(Xenopus
laevis) 		6 / 8 HIS A  47
ASN A  49
ARG A  51
ASN A  64
TRP A  71
GLU A  74
 GAL  A 202 ( 3.9A)
GAL  A 202 (-4.0A)
GLC  A 201 (-2.7A)
GAL  A 202 (-3.9A)
GAL  A 202 ( 3.7A)
GLC  A 201 (-2.8A)
 0.35A 6b94A-3wucA:
23.9		 6b94A-3wucA:
42.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 3wuc GALECTIN
(Xenopus
laevis) 		7 / 10 HIS A  47
ASN A  49
ARG A  51
ASP A  57
ASN A  64
TRP A  71
GLU A  74
 GAL  A 202 ( 3.9A)
GAL  A 202 (-4.0A)
GLC  A 201 (-2.7A)
None
GAL  A 202 (-3.9A)
GAL  A 202 ( 3.7A)
GLC  A 201 (-2.8A)
 0.42A 6b94A-3wucA:
23.9
6b94B-3wucA:
23.9		 6b94A-3wucA:
42.35
6b94B-3wucA:
42.35