SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wuf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		3 / 3 THR A  80
THR A  58
PRO A  81
 None
 0.81A 1dscC-3wufA:
undetectable		 1dscC-3wufA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		4 / 8 SER A 177
VAL A 178
LEU A 139
TYR A 187
 None
 1.03A 1fduB-3wufA:
undetectable		 1fduB-3wufA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		4 / 8 TYR A  89
GLU A  82
GLN A 126
SER A 318
 None
ZN  A 401 (-2.1A)
None
None
 1.25A 1nx9A-3wufA:
undetectable		 1nx9A-3wufA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		4 / 8 TYR A  89
GLU A  82
GLN A 126
SER A 318
 None
ZN  A 401 (-2.1A)
None
None
 1.23A 1nx9B-3wufA:
undetectable		 1nx9B-3wufA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		4 / 8 TYR A  89
GLU A  82
GLN A 126
SER A 318
 None
ZN  A 401 (-2.1A)
None
None
 1.24A 1nx9C-3wufA:
undetectable		 1nx9C-3wufA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		4 / 8 TYR A  89
GLU A  82
GLN A 126
SER A 318
 None
ZN  A 401 (-2.1A)
None
None
 1.24A 1nx9D-3wufA:
undetectable		 1nx9D-3wufA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		5 / 10 GLY A 237
VAL A 238
GLY A 239
MET A 240
VAL A 265
 None
 1.07A 1pwyE-3wufA:
undetectable		 1pwyE-3wufA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		5 / 10 GLY A 237
VAL A 238
GLY A 239
MET A 240
VAL A 265
 None
 1.16A 1v3qE-3wufA:
undetectable		 1v3qE-3wufA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		5 / 12 ASP A 291
GLY A 247
ALA A 246
PRO A 341
ALA A 342
 None
 1.06A 2b7zA-3wufA:
undetectable		 2b7zA-3wufA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		5 / 12 ASP A 291
GLY A 247
ALA A 246
PRO A 341
ALA A 342
 None
 1.06A 2b7zB-3wufA:
undetectable		 2b7zB-3wufA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		4 / 6 ASN A 112
GLN A 114
THR A  58
PRO A  81
 None
 1.04A 2ez7A-3wufA:
undetectable		 2ez7A-3wufA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		3 / 3 ASN A 207
ILE A 235
MET A 224
 None
 0.85A 2h42C-3wufA:
undetectable		 2h42C-3wufA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		4 / 6 LEU A 272
VAL A 310
PHE A  54
VAL A 296
 None
 1.15A 3soaA-3wufA:
undetectable		 3soaA-3wufA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		5 / 12 GLN A  78
ASP A 162
GLY A 307
ALA A 268
ALA A 242
 None
 1.00A 3sudC-3wufA:
undetectable		 3sudC-3wufA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		5 / 12 GLY A 307
VAL A 302
GLY A  44
ALA A  47
ALA A 347
 None
 1.01A 3sugA-3wufA:
undetectable		 3sugA-3wufA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		3 / 3 TRP A 319
VAL A 310
TRP A 311
 None
 1.00A 3zq8C-3wufA:
undetectable
3zq8D-3wufA:
undetectable		 3zq8C-3wufA:
10.53
3zq8D-3wufA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		5 / 12 GLY A 213
GLY A 215
PRO A 216
ILE A 211
ASN A 210
 None
ZN  A 404 ( 4.9A)
None
None
None
 0.99A 4gc9A-3wufA:
undetectable		 4gc9A-3wufA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		5 / 11 PHE A  76
SER A  74
LEU A  43
GLY A  44
ALA A 246
 None
 1.19A 4l6v1-3wufA:
undetectable
4l6v6-3wufA:
undetectable		 4l6v1-3wufA:
18.16
4l6v6-3wufA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		5 / 9 PHE A  76
SER A  74
LEU A  43
GLY A  44
ALA A 246
 None
 1.25A 4l6va-3wufA:
undetectable
4l6vf-3wufA:
undetectable		 4l6va-3wufA:
18.16
4l6vf-3wufA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		5 / 9 ASP A 208
VAL A 225
TYR A 206
PHE A 260
GLY A 237
 None
 1.21A 4mm5A-3wufA:
undetectable		 4mm5A-3wufA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		5 / 10 ASP A 208
VAL A 225
TYR A 206
PHE A 260
GLY A 237
 None
 1.28A 4mm7A-3wufA:
undetectable		 4mm7A-3wufA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		3 / 3 SER A 318
ASP A 315
GLN A 288
 None
 0.79A 4oltA-3wufA:
undetectable
4oltB-3wufA:
undetectable		 4oltA-3wufA:
24.30
4oltB-3wufA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		3 / 3 GLN A 288
SER A 318
ASP A 315
 None
 0.75A 4qwpA-3wufA:
undetectable
4qwpB-3wufA:
undetectable		 4qwpA-3wufA:
24.30
4qwpB-3wufA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		4 / 6 GLY A  55
SER A  77
TYR A  53
GLY A  44
 None
 0.89A 5k4pA-3wufA:
undetectable		 5k4pA-3wufA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		4 / 8 ILE A 245
GLN A 288
TYR A 292
VAL A 320
 None
 1.08A 5vlmF-3wufA:
undetectable		 5vlmF-3wufA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		4 / 8 SER A 177
GLN A 181
TYR A 187
MET A 143
 None
 1.31A 5wqpA-3wufA:
undetectable		 5wqpA-3wufA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		5 / 12 ASP A 291
SER A 318
THR A 281
GLY A 326
LEU A 278
 None
 1.08A 6b0lB-3wufA:
undetectable		 6b0lB-3wufA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		4 / 7 ALA A 101
THR A 100
TYR A  99
PRO A 128
 None
ZN  A 402 (-3.8A)
None
None
 0.71A 6cduA-3wufA:
undetectable
6cduE-3wufA:
undetectable		 6cduA-3wufA:
25.00
6cduE-3wufA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		4 / 7 PRO A 128
ALA A 101
THR A 100
TYR A  99
 None
None
ZN  A 402 (-3.8A)
None
 0.74A 6cduH-3wufA:
undetectable
6cduI-3wufA:
undetectable		 6cduH-3wufA:
25.00
6cduI-3wufA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 3wuf ENDO-1,4-BETA-XYLANA
SE A
(Streptomyces
sp.) 		5 / 12 ILE A 308
GLY A 293
ALA A 294
ASP A 291
LEU A 244
 None
 1.09A 6dwnD-3wufA:
undetectable		 6dwnD-3wufA:
14.47