SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wuy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A  93
ALA A  96
ALA A  97
LEU A  35
VAL A 108
 None
 1.07A 1fbyA-3wuyA:
undetectable		 1fbyA-3wuyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A  93
ALA A  96
ALA A  97
LEU A  35
VAL A 108
 None
 1.08A 1fbyB-3wuyA:
undetectable		 1fbyB-3wuyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 ILE A  38
ALA A  97
VAL A 104
LEU A 272
ALA A  16
 None
 1.07A 1n4hA-3wuyA:
undetectable		 1n4hA-3wuyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A  93
ALA A  96
ALA A  97
LEU A  35
VAL A 108
 None
 1.03A 1xdkE-3wuyA:
undetectable		 1xdkE-3wuyA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 VAL A 161
THR A 160
VAL A 130
ILE A 122
 None
 0.89A 2qbmA-3wuyA:
undetectable		 2qbmA-3wuyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 PRO A 257
THR A 159
VAL A 161
GLY A 162
 None
 1.11A 3elzA-3wuyA:
undetectable		 3elzA-3wuyA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 HIS A 213
SER A 217
PHE A 279
LEU A 164
HIS A 189
 None
 1.27A 3lxeA-3wuyA:
undetectable		 3lxeA-3wuyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 VAL A  50
LEU A  48
ILE A 122
GLY A 165
ALA A 166
 None
 1.03A 3n8yA-3wuyA:
undetectable		 3n8yA-3wuyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLY A 248
SER A 196
TRP A 227
 None
 0.94A 4e7cD-3wuyA:
undetectable		 4e7cD-3wuyA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 SER A  63
TYR A  59
MET A 197
LEU A 246
 None
 1.22A 4hxyB-3wuyA:
undetectable		 4hxyB-3wuyA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 271
ALA A  18
ILE A 255
ASN A 223
SER A 256
 None
 0.96A 4rtmA-3wuyA:
undetectable		 4rtmA-3wuyA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLY A 271
ALA A  18
ILE A 255
SER A 256
PRO A 265
 None
 1.02A 4rtmA-3wuyA:
undetectable		 4rtmA-3wuyA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 ALA A 267
HIS A 261
ALA A 253
GLU A 207
 None
 1.20A 5a06C-3wuyA:
undetectable
5a06D-3wuyA:
undetectable		 5a06C-3wuyA:
24.05
5a06D-3wuyA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 ILE A  93
LEU A 106
PHE A 123
THR A  84
 None
 1.06A 5b1aN-3wuyA:
undetectable
5b1aW-3wuyA:
undetectable		 5b1aN-3wuyA:
21.72
5b1aW-3wuyA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLU A 171
HIS A 172
ARG A 178
 None
 1.00A 5uunA-3wuyA:
undetectable		 5uunA-3wuyA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 PHE A 193
PRO A 194
GLY A 195
THR A 225
 None
 0.89A 5x24A-3wuyA:
undetectable		 5x24A-3wuyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 106
GLY A 127
PHE A  51
ILE A  49
ILE A  38
 None
 1.06A 6ebzA-3wuyA:
undetectable		 6ebzA-3wuyA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 106
GLY A 127
PHE A  51
ILE A  49
ILE A  38
 None
 1.08A 6ebzB-3wuyA:
undetectable		 6ebzB-3wuyA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 106
GLY A 127
PHE A  51
ILE A  49
ILE A  38
 None
 1.05A 6ebzD-3wuyA:
undetectable		 6ebzD-3wuyA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3wuy NITRILASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 106
GLY A 127
PHE A  51
ILE A  49
ILE A  38
 None
 1.05A 6gp2A-3wuyA:
undetectable		 6gp2A-3wuyA:
12.20